Clinical trials: Lipolysis
Metabolic Diseases, Growth Hormone Treatment
Lipolytic Effects of GH in Human Subjects in Vivo
Growth hormone (GH) induces fat metabolism. The mechanisms underlying the fat metabolizing effects of GH remain elusive. However, it is known that insulin suppresses fat metabolism, and GH inhibits the expression of certain…
- Trial name
- NCT02782221
- Testing
- Growth Hormone, Pegisomant
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Whole Body Catabolisme Induced by Glucocorticoids
Glucocorticoid Induced Whole Body Catabolisme
The main purpose of the trial is to advance our knowledge on the possible mechanism underlying the catabolic effects of long-term treatment with glucocorticoid.
- Trial name
- NCT01762540
- Testing
- Glucocorticoids, Calcium Supplement
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Metabolic Effects of Four-week Lactate-ketone Ester Supplementation
Recent research reveals intriguing results concerning the role of exogenous lactate and the ketone body 3-hydroxybutyrate (3-OHB) as therapeutic tools to combat obesity and related conditions.
- Trial name
- MetaLaKe (NCT05917873)
- Testing
- LaKe Ester
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Subcutaneous Fat
Effects of Ultrasound Cavitation Focused on Located Adiposity
The aim of this study is to evaluate the effect of cavitation ultrasound focused on localized adiposity and its effects associated with stereodynamic lymphatic drainage.
- Trial name
- NCT02539043
- Testing
- LIPOFOCUS
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Healthy
Effects of Protein Timing and Resistance Exercise on Fat Metabolism
The extent to which resistance exercise training and protein timing effects localized (belly fat) and systemic (whole body) fat metabolism in resistance-trained women is unknown.
- Trial name
- NCT03573687
- Testing
- Micellar Casein Protein, Resistance Exercise Training
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Florida State University
Obesity
Regional Lipolysis Insulin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults.
- Trial name
- NCT06392854
- Testing
- Insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2
Effect of Metformin on Exercise-induced Lipolysis
The aim of this study is to investigate whether metformin has inhibitory effect on exercise-induced lipolysis in subcutaneous adipose tissue in healthy lean man.
- Trial name
- NCT03189732
- Testing
- Metformin Oral, Metformin local in AT, Exercise
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Hyperlactatemia, Healthy
The Role of Lactate in Lipolysis and Catabolism in Humans
Lactate may have anti-lipolytic effects when plasma concentrations of lactate reach levels similar to those seen during high intensity exercise.
- Conditions
- Hyperlactatemia, Healthy, Lactate
- Trial name
- LILACH (NCT04710875)
- Testing
- Na-lactate, Sodium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Insulin Regulation of Lipolysis and Lipolysis Proteins
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which…
- Trial name
- NCT03866408
- Testing
- Immediate weight loss, Pioglitazone, Deferred weight loss
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Healthy
IL-6 Regulation of Substrate Metabolism and Influence of Obesity
The aim of the study is to investigate the effects of blocking IL-6 signaling with tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and obese humans.
- Trial name
- NCT03967691
- Testing
- Tocilizumab infusion, Saline 0.9%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity, Hyperinsulinemia
Natriuretic Peptides and Metabolic Risk in Obesity
The investigators are examining: 1. the relationships of insulin levels and natriuretic peptide hormone levels, and 2. the effects of administering an infusion of natriuretic peptide hormone on the breakdown of fat in healthy…
- Trial name
- NCT02642523
- Testing
- Nesiritide, Insulin, Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy, Obesity
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans
Leptin is a hormone that acts in the body as a chemical messenger. It is produced in fat cells and is believed to regulate body weight in humans. Leptin decreases appetite and influences the energy balance of the body.
- Trial name
- NCT00001722
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Fat Burn
Effect of BTL-899 Device for Non-invasive Lipolysis on Human Flanks
This study will evaluate the clinical safety and the performance of the BTL-899 device (with its 899-AP-C-4 and 899-AP-C-5 applicators) during treatment of the flanks (also known as "love handles").
- Trial name
- NCT05260164
- Testing
- HIFEM+RF
- Where
- Bulgaria
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Breast Lift
Clinical Evaluation of RFAL of Breast Envelope and NAC Position
This single center clinical study is intended to determine the safety and efficacy of using Radiofrequency (RF) energy for minimally invasive breast lift procedure.
- Trial name
- NCT03863834
- Testing
- InModeRF
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- InMode MD Ltd.
Energy Intake
Glycogen and Appetite
Obesity is the outcome of chronic excessive energy intake and reduced energy expenditure leading to energy imbalance. It is a risk factor for many preventable diseases such as metabolic disease and its consequences such as type 2…
- Trial name
- NCT05417659
- Testing
- Exercise plus carbohydrate, Exercise plus niacin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Bath
Thighs Circumferential Reduction, Subcutaneous Fat Cell Disruption
Effect of the XP1100RF Therapy on Thighs Circumference Reduction
This study was designed to demonstrate safety and efficacy of the XP1100RF for non-invasive temporary reduction of thighs circumference by disruption of adipocyte cells.
- Trial name
- NCT02527369
- Testing
- XP1100RF
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Lipolysis
RF and PEMF Following Liposuction
The Venus Legacy LB2 Body applicator is intended for circumference reduction treatment by reducing fat cell size and enhancing collagen synthesis as the result of thermal and non-thermal collagen stimulation.
- Trial name
- NCT03588702
- Testing
- RF and PEMF treatment
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Healthy
Dietary Polyphenols and Insulin Sensitivity in Overweight and Obese Humans
In this double-blind, randomized, placebo-controlled study, we aim to investigate the effects of a long-term supplementation on insulin sensitivity, mitochondrial function and substrate metabolism in healthy overweight men and…
- Trial name
- NCT02381145
- Testing
- EGCG+RSV-supplementation
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Improvement of Abdomen Appearance
Effect of the BTL-899 Therapy for Non-invasive Lipolysis and Circumference Reduction of Abdomen
The study is a prospective open-label single-arm study that includes three treatment procedures and four follow-up visits.
- Trial name
- NCT03270150
- Testing
- BTL-899
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Lipolysis, Overweight and Obesity
Efficacy of a Lipolytic Cream in an Overweight and Obesity Treatment
The coadyouvant efficacy of a combination of cosmetics ingredients in the form of a lipolytic cream with hypocaloric diet and physical activity were assessed and compared with with hypocaloric diet and physical activity for…
- Conditions
- Lipolysis, Overweight and Obesity, Diet Modification, Physical Activity
- Trial name
- NCT03721185
- Testing
- Dr.K. Treatment
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- BiomediKcal