Clinical trials: Liposomal Bupivacaine
Fibroid Uterus
Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy
The study team will be randomizing patients presenting for open myomectomy to either received transversus abdominal plane blocks with either liposomal bupivacaine or standard bupivacaine.
- Trial name
- NCT04272086
- Testing
- Bupivacaine, Bupivacaine liposome, normal saline
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Pain, Surgery
Comparison of Epidural and TAP Block in Abdominal Surgery
This study will compare the infiltrative transversusabdominis plane (TAP) block with liposomal bupivacaine to epidural analgesia (EA) in major abdominal surgery .
- Conditions
- Acute Pain, Surgery, Regional Anesthesia
- Trial name
- NCT01848951
- Testing
- Epidural, TAP Block
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Nebraska
Acute Pain, Orthopaedic Surgery
Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery.
This study will prospectively compare the preventive effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine alone on rebound pain after nerve block in patients undergoing orthopedic extremity…
- Trial name
- NCT07606911
- Testing
- liposomal bupivacaine, Normal Saline
- Where
- China
- Volunteers
- 668 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Amputation, Anesthesia, Local
Use of Long-acting Bupivacaine In Lower Extremity Amputation
The purpose of this investigator-initiated study is to assess the use of liposomal bupivacaine in major extremity amputation and its effects on post-operative opioid narcotic use, length of stay, and in-hospital costs.
- Conditions
- Amputation, Anesthesia, Local, Opioid Use
- Trial name
- NCT04360421
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Loma Linda University
Postoperative Pain
Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty
The primary objectives of Part 1 are to (1) evaluate three dose levels of liposome bupivacaine versus placebo with respect to the magnitude and duration of the analgesic effect achieved following single dose injection femoral…
- Trial name
- NCT01683071
- Testing
- EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
- Where
- 30 sites in United States
- Volunteers
- 297 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Shoulder Pain, Rotator Cuff Tear
Efficacy of Interscalene Brachial Plexus Block With Liposomal Bupivacaine for Arthroscopic Shoulder Surgery
The purpose of this study is to compare the quality and duration of pain relief after shoulder surgery provided by a single injection of liposomal bupivacaine versus standard bupivacaine when administered as an interscalene…
- Trial name
- NCT01977352
- Testing
- Liposomal bupivacaine, Bupivacaine 0.25%
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Liposomal Bupivacaine, Microvascular Decompression
Effect of Local Infiltration of Liposomal Bupivacaine on Postoperative Analgesia in Patients With Craniotomy Microvascular Decompression
Background: Approximately 60-84% of patients undergoing craniotomy experience moderate to severe pain within 48 hours postoperatively, with posterior fossa craniotomy patients experiencing more severe pain.
- Trial name
- NCT07245290
- Testing
- liposomal bupivacaine local infiltration, normal operation
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post Operative Pain
Comparison of Exparel to Marcaine in Post-Surgical Analgesia in Bariatrics
This study is designed to evaluate the use of bupivacaine liposome 1.3% compared bupivacaine 0.5% in pain control in post-operative laparoscopic bariatric surgery patient The purpose of this study is to evaluate two local…
- Trial name
- NCT02752230
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Sleeve Gastrectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kettering Health Network
Postoperative Pain
Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial
The goal is to find out if Exparel (liposomal bupivacaine) given as an injection decreases pain score if given into the vaginal cuff right before starting the minimally invasive (robotic-assisted or laparoscopic) total…
- Trial name
- NCT05823363
- Testing
- Exparel with Bubivacaine, Bupivacaine only
- Where
- United States
- Sponsor
- Jefferson Drapkin
Pain, Postoperative, ACL
Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction
Liposomal bupivacaine injectable suspension (Exparel), manufactured by Pacira Pharmaceuticals, is an FDA-approved, long-lasting nonopioid analgesic that is indicated for single-dose infiltration in adults to produce postsurgical…
- Trial name
- NCT05161221
- Testing
- OxyCODONE 5 mg Oral Tablet, Naproxen 500 Mg, Tylenol Pill
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Colorectal Disorders
Pain Control in Colorectal Surgery: Liposomal Bupivacaine Block Versus Intravenous Lidociane
To compare the analgesic impact of intravenous perioperative lidocaine infusion with preoperative liposomal bupivacaine TAP block in colorectal surgery.
- Trial name
- Exparel (NCT04005859)
- Testing
- Exparel, IV Lidocaine
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Acute Pain
TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Robotic Hysterectomy
The purpose of the study is to compare pain control after robotic hysterectomy surgery using either liposomal bupivacaine or Bupivacaine when injected during a transversus abdominis plane (TAP) block.
- Trial name
- NCT02289079
- Testing
- Bupivacaine, liposomal bupivacaine
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion
This study will describe postoperative pain management for spine surgery patients receiving liposomal bupivacaine (Exparel®) compared to patients not receiving the drug.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Spondylolisthesis
- Trial name
- NCT03745040
- Testing
- Liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Allina Health System
ACL Tear, Opioid Misuse
Exparel vs. ACB With Bupivacaine for ACL Reconstruction
Opioid misuse and addiction among children and adolescents is an increasingly concerning problem. Post-surgical opioid prescriptions for commonly performed surgeries such as anterior cruciate ligament reconstruction (ACLR)…
- Conditions
- ACL Tear, Opioid Misuse, Pain, Anxiety
- Trial name
- NCT06274008
- Testing
- Exparel
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Shoulder Arthroscopy
Determination of the Optimal Volume of 0.5% Bupivacaine Liposome in Single-Injection Interscalene Brachial Plexus Block: A Bayesian Phase I/II Trial
This single-center, prospective, single-arm, Bayesian phase I/II clinical trial evaluates the incidence of HDP following ISB in shoulder arthroscopy and determines the optimal volume of a single injection of liposomal bupivacaine.
- Trial name
- NCT06972680
- Testing
- Bupivacaine Liposomes(BL)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Postoperative Pain, Liposomal Bupivacaine
Efficacy of Liposomal Bupivacaine for Transversus Abdominis Plane Block
This is a single-center, randomized, single-blind, parallel-group clinical trial. The study aims to compare the analgesic efficacy of liposomal bupivacaine versus ropivacaine for transversus abdominis plane (TAP) block in…
- Trial name
- NCT07577934
- Testing
- Liposomal Bupivacaine TAP block, Ropivacaine TAP blocks
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tianjin First Central Hospital
Hemorrhoid Surgery, Liposome Bupivacaine
The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery
Hemorrhoids represents the most prevalent condition among anorectal disorders. Due to the unique anatomical characteristics of the perianal region, patients frequently experience severe postoperative pain, which may lead some…
- Conditions
- Hemorrhoid Surgery, Liposome Bupivacaine, Pain Management, Local Infiltration
- Trial name
- NCT07442539
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Pain and Diaphragmatic Dysfunction After Shoulder Arthroscopy
Effect of Optimal Biological Volume Bupivacaine Liposome Interscalene Brachial Plexus Block on Postoperative Analgesia After Shoulder Arthroscopy
This study aims to evaluate whether 15ml/75mg low-dose bupivacaine liposome is non-inferior to 15ml/133mg standard-dose bupivacaine liposome for postoperative analgesia in interscalene brachial plexus block during arthroscopic…
- Trial name
- NCT07792044
- Testing
- OBV bupivacaine liposome group, Standard dose bupivacaine liposome group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Pain, Postoperative, Arthroplasty, Replacement, Knee
Liposomal Bupivacaine in Total Knee Arthroplasty
Liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief. Despite its long-acting analgesic potential, liposomal bupivacaine is significantly more expensive than other local anesthetic alternatives.
- Conditions
- Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
- Trial name
- NCT02426164
- Testing
- Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
- Where
- United States
- Sponsor
- Miller Orthopedic Specialists
Pain, Postoperative
Interscalene Catheter vs. Interscalene Liposomal Bupivacaine for Arthroscopic Rotator Cuff Repair
Arthroscopic rotator cuff repair often causes significant postoperative pain. An interscalene nerve catheter is an effective and proven method to help reduce postoperative pain and decrease opioid use around the time of shoulder…
- Trial name
- NCT04571606
- Testing
- Single injection peripheral nerve block with liposomal bupivacaine (Exparel), Single injection peripheral nerve block with 0.25% bupivacaine and subsequent peripheral nerve catheter with 0.2% bupivacaine infusion via onQ pain pump
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill