Clinical trials: Liver Biopsy
Cirrhosis, Chronic Hepatitis
Sedation and Analgesia for Transjugular Liver Biopsy: A Randomized Double Blind Placebo Controlled Trial
Transjugular liver catheterisation allows the measurement of hepatic venous pressure gradient (HVPG) and the sampling of liver tissue but patient's tolerance to the procedure is unknown.
- Conditions
- Cirrhosis, Chronic Hepatitis, Anxiety
- Trial name
- NCT00596414
- Testing
- transjugular liver biopsy, midazolam, midazolam + pethidine
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Erasme University Hospital
Hepatitis B, Chronic
Tenofovir Alafenamide With Fine Needle Aspiration Biopsy in Chronic Hepatitis B:
The objective of this study is to identify immunological mechanisms that contribute to normalization of liver inflammation in chronic hepatitis B (CHB) patients starting the antiviral nucleoside analogue, Tenofovir alafenamide…
- Trial name
- NCT04070079
- Testing
- Tenofovir Alafenamide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Fibrosis
Comparison of EUS-Guided Liver Biopsy With Percutaneous Liver Biopsy
There are several ways to perform liver biopsies, including the percutaneous route (historical gold standard) and via endoscopic ultrasound (EUS) guidance.
- Trial name
- NCT02947516
- Testing
- Endoscopic ultrasound-guided liver biopsy, Percutaneous liver biopsy
- Sponsor
- Brigham and Women's Hospital
Liver Fibrosis, MRI
Quantification of Hepatic Fibrosis by IVIM Sequences in 1.5T MRI
Quantification of hepatic fibrosis by IVIM sequences in 1.5T MRI.
- Conditions
- Liver Fibrosis, MRI, IVIM, Liver Biopsy
- Trial name
- IVIM-MRI (NCT03173287)
- Testing
- Quantification of liver fibrosis
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Clermont-Ferrand
Alcoholism, Cirrhosis
Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound
The purpose of this study is to determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis, using endoscopic ultrasound.
- Conditions
- Alcoholism, Cirrhosis, Hepatitis c
- Trial name
- NCT01208311
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Liver Biopsy
Evaluation of a Support Software in the Planning and Real-time Monitoring of the Insertion of Needles in Interventional Magnetic Resonance Imaging (MRI): Liver Biopsy Case
To demonstrate that the use of Standard @IFE and Planning@IFE features of the IFE software, compared to the current method, when planning and inserting the needle under MRI monitoring in the context of liver biopsies enable: a…
- Trial name
- IFE (NCT02573545)
- Testing
- Planning@IFE and Standard@IFE Software, MR Syngo (Numaris/4) software
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Strasbourg, France
Liver Transplants
Estimation of Steatosis on Liver Transplants by Intraoperative Spectrometry
The goal is to have a small spectrometer (pocket size) , reliable and rapid tool that can be used during liver harvesting, which enables macrosteatosis to be evaluated reproducibly and selectively, at any time.
- Trial name
- iGRAISSE (NCT05106322)
- Testing
- intraoperative spectrometer scan
- Where
- 3 sites in France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Diseases, Liver Fibrosis
Prospective Single Centre Observational Study to Compare the Diagnostic Yield of Different Modalities of Liver Biopsy
The goal of this study is to learn about endoscopic ultrasound(EUS) guided liver biopsy and how this compares to traditional methods of obtaining liver biopsy samples, in patients with liver disease.
- Trial name
- NCT05912179
- Testing
- Liver biopsy - percutaneous, Liver biopsy - transjugular, liver biopsy - EUS guided
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Metabolic Dysfunction-assocated Steatohepatitis/ Nonalcoholic Fatty Liver Disease
Study of TVB-2640 in Subjects With Nonalcoholic Steatohepatitis (NASH)
This is a Phase 2, multi-center, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy on TVB-2640 in subjects with non-alcoholic steatohepatitis (NASH).
- Trial name
- NCT04906421
- Testing
- TVB-2640
- Where
- 117 sites in United States, Canada and 2 more
- Volunteers
- 168 people
- Sponsor
- Sagimet Biosciences Inc.
Liver Cirrhosis
EUS-guided Versus Percutaneous Ultrasound-guided Biopsy for Parenchymal Liver Disease
Liver biopsy may be indicated in various clinical scenarios to help diagnose and manage liver diseases. Endoscopic ultrasound (EUS) liver biopsy and percutaneous USG guided liver biopsy are two methods used to obtain liver tissue…
- Trial name
- NCT06047327
- Testing
- EUS guided liver biopsy, Percutaneous Liver Biopsy
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Bleeding Disorder, Spleen Lesion
Operator and Patient Acceptance of Radiofrequency Cautery of the Biopsy Track During Percutaneous Liver, Kidney or Spleen Biopsy Procedures.
The goal of this study is to assess the physician and patient experience of radio frequency (RF) track cautery in patients undergoing needle biopsy of the liver, kidney, or spleen who have one or more risk factors for…
- Conditions
- Bleeding Disorder, Spleen Lesion, Liver Diseases, Kidney Diseases
- Trial name
- NCT05790109
- Testing
- RF track cautery during percutaneous organ biopsy
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury
Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver Transplantation
Hepatorenal Syndrome (HRS) is a serious complication that can occur in patients with liver cirrhosis, characterised by kidney dysfunction, or acute kidney failure (AKI).
- Conditions
- Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury, Liver Transplant
- Trial name
- NCT07300709
- Testing
- renal biopsy
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The University of Hong Kong
NAFLD, Alcoholic Hepatitis
EUS Guided Liver Biopsy - Will it Give Better Yield, More Tissue With Less Complication?
Liver biopsy would be done by Endoscopic Ultrasound using Acquire needle.
- Trial name
- NCT04235855
- Testing
- Endoscopic USG guided Liver biopsy, Percutaneous Liver Biopsy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Portal Hypertension, Cirrhosis
A Pilot Study: Defining Peripheral Endothelial Function in Portal Hypertensive Cirrhotic Patients
Rationale for the study: To try and define PEF in cirrhotic patients with CSPH, and maybe to try to find a correlation between HVPG ( hepatic vein pressure gradient ) result and PEF result in a way that the result of the PEF test…
- Trial name
- NCT02356250
- Sponsor
- Eyal Ashkenazi
Pancreatic Cancer
C-VISA BikDD: Liposome in Advanced Pancreatic Cancer
The goal of this clinical research study is to find the highest tolerable dose of BikDD nanoparticle that can be given to patients with advanced cancer of the pancreas. The safety of this drug will also be studied.
- Trial name
- NCT00968604
- Testing
- BikDD Nanoparticle
- Sponsor
- M.D. Anderson Cancer Center
Obesity, Non-Alcoholic Steatohepatitis
EUS Guided Core Liver Biopsy and IGB Placement for the Diagnosis and Management of NASH and Obesity
This study is designed to investigate the impact of weight loss achieved with the IGB on NASH with early fibrosis in a select cohort of patients with obesity preselected to have a high pre-test probability of having NASH with…
- Trial name
- NCT02880189
- Testing
- Orbera Intragastric Balloon, Endoscopic Ultrasound Guided Core Liver Biopsy
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Liver Diseases
Wet Heparin for Obtaining Liver Tissue for EUS Guided Liver Biopsy
Since its inception, endoscopic ultrasound with fine needle aspiration (EUS-FNA) has proven a valuable diagnostic and prognostic tool for evaluating a diverse number of pathologies.
- Trial name
- NCT03103997
- Testing
- EUS-guided liver biopsy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Cancer of Digestive System, Ovarian Cancer
Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)
This study aims at demonstrating the feasibility of probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy (nCLE).
- Trial name
- PERSEE (NCT02312167)
- Testing
- confocal laser endomicroscopy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Mutualiste Montsouris
Lung Neoplasms, Liver Neoplasms
A Comparison of Methods for Assisting Needle Angle Selection During Image-guided Tissue Biopsy
Background: Currently, standard procedures for biopsies that are guided by computed tomography (CT) imaging involve CT scans and a computer program to plan and illustrate where the physician will place the needle to obtain the…
- Conditions
- Lung Neoplasms, Liver Neoplasms, Kidney Neoplasms, Cancer
- Trial name
- NCT01218854
- Testing
- Needle angle measurement
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Liver Cancer, Biliary Tract Cancer
Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA.
- Conditions
- Liver Cancer, Biliary Tract Cancer, Pancreatic Cancer
- Trial name
- NCT06139042
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 1,608 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine