Clinical trials: Liver Failure After Operative Procedure
Surgery, Hepatocellular Carcinoma
Transient Elastography in Hepatectomy for Hepatocellular Carcinoma
The purpose of this study is to determine whether liver transient elastography performed before the surgical procedure is able to predict liver failure in patients undergoing hepatectomy for hepatocellular carcinoma.
- Trial name
- NCT01441453
- Testing
- FibroScan (Transient Elastography measurement)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hepatic Cancer, Hepatocellular Carcinoma
Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy
How to accurately and safely evaluate regional liver function before hepatectomy remains an important unsolved problem in the surgical management of hepatocellular carcinoma (HCC).
- Conditions
- Hepatic Cancer, Hepatocellular Carcinoma, Intrahepatic Cholangiocellular Carcinoma, Metastatic Hepatocellular Carcinoma
- Trial name
- NCT07704203
- Testing
- Three-Dimensional Magnetic Resonance Elastography
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Liver Cancer, Liver Metastases
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
The DRAGON registry aims to collect data on combined portal and hepatic vein embolization (PVE/HVE) for liver tumors, a technique expected to enhance liver regeneration compared to standard PVE.
- Trial name
- NCT07717437
- Where
- 31 sites in United States, Australia and 11 more
- Volunteers
- 350 people
- Sponsor
- Maastricht University Medical Center
MRI, Liver Resection
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI
Post hepatectomy liver failure (PHLF) is one of the most severe complications after liver re-section. Preoperative evaluation of liver function is complicated and imprecise.
- Conditions
- MRI, Liver Resection, Liver Failure as A Complication of Care
- Trial name
- MR-Predict (NCT04692259)
- Testing
- MRI
- Where
- 7 sites in Denmark, Finland and 2 more
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Acute Renal Failure
Development and Validation of an Enhanced Prediction Score for Postoperative Acute Renal Failure After Liver Resection
Post-operative acute renal failure is a severe post-operative complication and is associated with high mortality. The enhanced prediction score, including pre-as well as intra-operative predictors accurately predicted ARF…
- Trial name
- NCT01318798
- Where
- Switzerland
- Volunteers
- 549 people
- Sponsor
- University of Zurich
Kidney Failure
Does Terlipressin Improve Renal Outcome After Liver Surgery
The investigators aim to address whether terlipressin improves the renal outcome after liver surgery. Therefore the investigators are planning to conduct a double-blinded randomized control trial.
- Trial name
- TIROL (NCT02368249)
- Testing
- Terlipressin
- Where
- Switzerland
- Sponsor
- University of Zurich
Indocyanine Green, Postoperative Complications
One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort Study
Introduction: Hepatic insufficiency is a complication that puts the life of the patient undergoing resective surgery at risk. Thus, the diagnosis should be made early.
- Conditions
- Indocyanine Green, Postoperative Complications, Acute Liver Failure
- Trial name
- IGHI (NCT04570800)
- Volunteers
- 44 people
- Sponsor
- Castilla-La Mancha Health Service
Liver Failure
Gd-EOB-DTPA-enhanced T1 Map for Predicting Postoperative Liver Failure
Researchers designed this study to compare the value of the conventional circular region-of-interest (ROI) and whole-liver histogram-based analysis on gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced T1 map for predicting…
- Trial name
- NCT05592106
- Testing
- T1 mapping on gadoxetic acid-enhanced MRI
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Carcinoma, Hepatocellular, Alcoholic Cirrhosis
Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma
The aim of the investigators' study is to elucidate the relationship between a functional liver test (e.g., ICG) and the PREOPERATIVE value of portal hypertension in the patients with impaired liver function from alcoholic and…
- Conditions
- Carcinoma, Hepatocellular, Alcoholic Cirrhosis, Viral Cirrhosis, Postoperative Hepatic Failure
- Trial name
- NCT00827723
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Lausanne Hospitals
Liver Disease
The Association Between Gene Polymorphisms and Infectious Complications After Liver Surgery
The purpose of the study is to test whether the presence of polymorphisms in genes encoding substances of the innate immune response in patients undergoing partial hepatic resection because of benign or malignant hepatobiliary…
- Trial name
- NCT00887887
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
Hepatocellular Carcinoma
Ulinastatin Preventing Postoperative Hepatic Failure in Hepatocellular Carcinoma (HCC)
The purpose of this study is to confirm that Ulinastatin is a safe and effective drug and it can reduce the incidence of postoperative hepatic failure in HCC patients.
- Trial name
- NCT01643447
- Testing
- Ulinastatin, Diammonium glycyrrhizinate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Liver Failure, Major Hepatectomy
Pneumatic Reversible Portal Vein Diameter Modulation After Major Hepatectomy
This ring aimed to preserve an intra-hepatic porto-caval gradient inferior to 5 mm Hg during and after major hepatectomy (48h) to protect the liver during the initial phases of liver regeneration.
- Trial name
- MODHEP1 (NCT02390713)
- Testing
- MID-AVR
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Cirrhosis, Portal Hypertension
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure
- Trial name
- PERSEVERE (NCT04578301)
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Acute Renal Failure
Novel Prediction Score for Postoperative Acute Renal Failure (ARF) Following Liver Resection
ARF is a frequent event after hepatic resection and therefore clinically highly relevant. There is limited evidence on the incidence of postoperative ARF and its clinical relevance in patients undergoing liver resection.
- Trial name
- StV 11-2008 (NCT00743132)
- Where
- Switzerland
- Volunteers
- 569 people
- Sponsor
- University of Zurich
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Hepatic Encephalopathy, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery
This is a single-center, prospective, open-label, parallel-group exploratory clinical study designed to evaluate the safety and preliminary efficacy of fecal microbiota transplantation combined with standard medical therapy in…
- Conditions
- Hepatic Encephalopathy, Fecal Microbiota Transplantation, TIPS, Refractory Hepatic Encephalopathy
- Trial name
- NCT07683936
- Testing
- Fecal Microbiota Transplantation, Rifaximin、Lactulose, Dietary Fiber Prebiotic
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Liver Failure After Operative Procedure
A Machine Learning Architecture to Predict Post-Hepatectomy Liver Failure Using Liver Regeneration Biomarkers and Time-Phased Data
Post-hepatectomy liver failure (PHLF) is the leading cause of morbidity and mortality following major hepatectomy. Existing prediction models fail to capture the dynamic liver regeneration and perioperative changes, limiting…
- Trial name
- PHLF predictio (NCT05779098)
- Where
- China
- Volunteers
- 1,071 people
- Sponsor
- Shen Feng
Liver Cancer, Surgery
HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies
This observational clinical cohort study aims to evaluate the clinical utility of LiverMultiScan in quantifying liver health prior to liver resection or TACE.
- Conditions
- Liver Cancer, Surgery, Liver Regeneration, Colorectal Cancer Metastatic
- Trial name
- Hepatica (NCT03213314)
- Testing
- Multiparameter magnetic resonance imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 149 people
- Sponsor
- University of Edinburgh
Hepatic Insufficiency
Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies
Extended hepatectomies of 4 or more segments are complicated by high rates of morbidity and mortality, mainly related to hepatic liver failure.
- Trial name
- SCINTIVOL (NCT02753517)
- Testing
- Hepatobiliary scintigraphy
- Where
- 12 sites in France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Lille