Clinical trials: Liver Function Tests
Pulmonary Arterial Hypertension
The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study
The purpose of this study is to find out if spironolactone added to ambrisentan for Pulmonary Arterial Hypertension (PAH) will increase exercise capacity.
- Trial name
- NCT02253394
- Testing
- Ambrisentan plus Spironolactone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Hemorrhage
The EVARREST® Fibrin Sealant Patch Liver Study
To evaluate the safety and hemostatic effectiveness of EVARREST® Fibrin Sealant Patch (EVARREST) versus standard of care treatment (SoC) in controlling parenchymal bleeding during hepatic surgery.
- Trial name
- NCT01993888
- Testing
- EVARREST® Fibrin Sealant Patch, Standard of Care (SoC)
- Where
- 17 sites in United States, Australia and 2 more
- Volunteers
- 102 people
- Sponsor
- Ethicon, Inc.
Overweight, Abnormal Liver Function Tests
Evaluation of PK and Biomarkers After UDCA Administrations to Subjects Who Are Overweight and Have Liver Problems
A clinical study to evaluate pharmacokinetics, metabolomics and biomarker in subjects who are overweight and have liver problems after ursodeoxycholic acid multiple administration
- Trial name
- NCT03000218
- Testing
- Ursodeoxycholic acid, Metformin
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pregnancy Disease, Liver Diseases
Defining 'Normal' Liver Function Tests & FibroScan Values in Pregnancy
The main aim of this single-site prospective study is to use serum liver function tests and FibroScan as assessment tools to measure liver disease in pregnant women with or without liver disease at King's College Hospital.
- Trial name
- NCT03883789
- Testing
- FibroScan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Fatty Liver
A Study of Siliphos in Adults With Non-alcoholic Steatohepatitis (NASH)
The purpose of this study is to evaluate the dietary supplement Siliphos, which comes from milk thistle, to determine whether it is safe and well-tolerated in adults who have non-alcoholic steatohepatitis (NASH).
- Trial name
- NCT00443079
- Testing
- IdB 1016 (Siliphos)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Heather Patton
Liver Toxicity, Chemically-Induced
Livertoxcicity in Acute Leukemia Patients During Chemotherapy Treatment
Detection of hepatotoxcicity in acute leukemia and study the outcome of acute leukemia patients that suffer from hepatic toxiciyt
- Trial name
- NCT06383325
- Testing
- Chemotherapy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Non-Alcoholic Fatty Liver Disease
Cigarette Smoking in Non-alcoholic Steatohepatitis
This non-randomized clinical trial was performed to clarify the effect of cigarette smoking reduction on liver function and some anthropocentric indices in smoker patients with non-alcoholic steatohepatitis.
- Trial name
- NCT04688307
- Testing
- Motivational interviewing
- Where
- 2 sites in Iran
- Volunteers
- 104 people
- Sponsor
- Tehran University of Medical Sciences
Hepatitis B, Chronic, Hepatic Steatosis
Aerobic Exercise Training in Patients With Chronic Hepatitis B and Hepatic Steatosis
This study is a randomised, controlled, unblinded, clinical intervention trial consisting of 12 weeks of aerobic exercise training.
- Trial name
- FitLiver (NCT05265026)
- Testing
- High Intensity Interval Training
- Where
- Denmark
- Volunteers
- 19 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Transplant Recipients
Liver Transplant Recipients and 30-Second Lie-to-Sit Test
The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper…
- Trial name
- NCT07365098
- Testing
- 30-second lie-to-sit test, Modified Borg Scale, waist circumference
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Inonu University
HIV, Tuberculosis
Preliminary Evaluation of a Point-Of-Care Liver Function Test
The proposed preliminary field evaluation will compare a point-of-care (POC) transaminase test with the standard of care test used in an HIV clinic at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.
- Conditions
- HIV, Tuberculosis, Drug-Induced Liver Injury
- Trial name
- DFA (NCT01705041)
- Testing
- Diagnostics for All liver function test (LFT)
- Where
- Vietnam
- Volunteers
- 700 people
- Sponsor
- PATH
Liver Functions Tests
Desflurane and Sevoflurane in Pediatrics With Elevated Liver Enzymes
It is designed to compare effects of inhaled anaesthetic desflurane and sevoflurane on liver functions in pediatric cancer patients
- Trial name
- NCT04775212
- Testing
- Desflurane, Sevoflurane
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Liver Transplant Rejection
TRU-IMMUNO: Optimizing Liver Immunosuppression
This is a prospective, multi-center, randomized study. The primary objective is to evaluate the feasibility and utility of TruGraf/TRAC Liver testing used in addition to standard of care measures of liver dysfunction to guide…
- Trial name
- NCT05335551
- Testing
- Patients monitored with TruGraf and TRAC Liver testing
- Volunteers
- 130 people
- Sponsor
- Transplant Genomics, Inc.
Liver Function Tests
Effect of Exercise on Liver Cirrhosis
This randomized controlled study aimed to determine the effect of the exercise program to be applied in patients with cirrhosis on the patient's biochemistry parameters, quality of life, fatigue level, depression, and sleep…
- Trial name
- NCT05612334
- Testing
- exercise (5 minutes warm-up-30 minutes walking-5 minutes cooling down)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- HULYA KESKIN
End-stage Liver Disease (ESLD), Cirrhosis, Liver
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
The purpose of this study is to assess the safety and efficacy of RTX001 in patients with end-stage liver disease. This study is the first time RTX001, a macrophage cell therapy engineered to have an anti-inflammatory and…
- Conditions
- End-stage Liver Disease (ESLD), Cirrhosis, Liver, Cirrhosis, Decompensated, Liver Diseases
- Trial name
- EMERALD (NCT06823713)
- Testing
- RTX001
- Where
- 15 sites in Spain, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Resolution Therapeutics Limited
Obesity
Meta-analysis of Orlistat Laboratory Data From Placebo-controlled Clinical Trials
Roche and GSK will carry out a meta-analysis of liver function data from trials of orlistat to establish whether there is any indication of liver toxicity.
- Trial name
- NCT01332448
- Testing
- Orlistat 120, Orlistat 60
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Psoriasis Chronic, Liver Fibrosis
An Observational Cohort Study Evaluating Fatty Liver Disease and Liver Fibrosis in Moderate to Severe Psoriasis
Main objectives and outcome measures. 1. Establish prevalence of and factors contributing to fatty liver disease and liver fibrosis in patients with psoriasis. Fatty liver disease diagnosed via ultrasound.
- Conditions
- Psoriasis Chronic, Liver Fibrosis, Fatty Liver, Non-alcoholic Fatty Liver Disease
- Trial name
- CORE (NCT02174367)
- Testing
- Transient elastography
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- King's College London
Hepatocellular Carcinoma
Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis
AIMS To evaluate the accuracy of HVPG (direct method), ICG-R15 and LSM/SSM (non-invasive methods) in predicting the risk of PHLF and hepatic decompensation; to evaluate the correlation between hepatic functional reserve (ICG-R15)…
- Trial name
- ProHype-ICG (NCT05800561)
- Testing
- Hepatic venous-portal gradient (HVPG) measurement
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- Federico II University
Hepatitis C, Nutritional Status
Effect of Agaricus Blazei (Murrill) ss. Heinemann (Sun Mushroom)
The aim of the study was to verify the influence of Agaricus blazei (Murrill) ss. Heinemann (A. blazei) on the evolution of nutritional state and liver function in hepatitis C patients.
- Conditions
- Hepatitis C, Nutritional Status, Hepatitis, Viral, Human
- Trial name
- NCT00564811
- Testing
- Agaricus blazei (Murrill) ss. Heinemann (sun mushroom)
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Liver Diseases, Healthy
Blood Collection for Development and Validation of Point-of-Care Diagnostic Liver Function Tests
This is an observational study exploring the performance of a novel point-of-care diagnostic testing platform designed to quantitate the presence of liver function biomarkers such as bilirubin.
- Conditions
- Liver Diseases, Healthy, Liver Cirrhosis, Liver Fibrosis
- Trial name
- NCT05457543
- Testing
- Adult
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Group K Diagnostics Inc.