Clinical trials: Liver Injury, Drug-Induced
HIV Pre-exposure Prophylaxis, HEPATITIS C (HCV)
Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)
Evaluate the feasibility, acceptability, and usability of the intervention (primary outcomes) and coping skills and resilience (secondary outcomes) of the telehealth intervention over two months (8 weekly sessions) in a…
- Conditions
- HIV Pre-exposure Prophylaxis, HEPATITIS C (HCV), Opioid Use Disorder
- Trial name
- NCT06799702
- Testing
- Telehealth Behavioral Intervention for promoting HIV and HCV care and MOUD among Persons who inject drugs (PWID)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Drug Induced Liver Injury
Drug-Induced Liver Injury (DILI) Network Retrospective
The purpose of this study is to establish retrospectively a nationwide registry of patients who have suffered drug-induced liver injury (DILI), and to collect, immortalize, and store serum, DNA, and lymphocytes from these…
- Trial name
- ILIAD (NCT00360646)
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Capsule.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Capsule (XLGB Capsule) through a non-intervention observational way.
- Trial name
- NCT03091244
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Drug-Induced Liver Injury, Anti-Tuberculous Drug Reaction
Assessing Antibiotic Induced Liver Injury for Stratification of Tuberculosis Patients
A panel of highly sensitive circulating biomarkers for acute liver injury have been identified and demonstrated to identify liver injury on first presentation to hospital before standard tests are elevated in patients with…
- Conditions
- Drug-Induced Liver Injury, Anti-Tuberculous Drug Reaction, Tuberculosis
- Trial name
- ALISTER (NCT03211208)
- Where
- United Kingdom
- Volunteers
- 194 people
- Sponsor
- University of Edinburgh
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Zhuanggu Guanjie Pill
This is a prospective registry study to surveil early liver injuries caused by Zhuanggu Guanjie Pill (ZGGJ Pill) through a non-intervention observational way.
- Trial name
- NCT03060252
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Drug Induced Liver Injury
Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury
The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.
- Trial name
- NCT01000766
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Drug-Induced Liver Injury
A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis
We will conduct a randomized placebo controlled trial to determine whether administration of intravenous (IV) NAC to participants with TB DIH, in dosages similar to that used in paracetamol poisoning, can improve recovery from…
- Trial name
- NAC in TB DIH (NCT02182167)
- Testing
- IV N-acetylcysteine (NAC), Water
- Where
- 2 sites in South Africa
- Volunteers
- 102 people
- Sponsor
- University of Cape Town
Drug Induced Liver Injury, Pruritus
Drug-induced Liver Injury: Itching Study
Idiosyncratic drug-induced liver injury (DILI) is an unpredictable adverse hepatic reaction to a medication used in its therapeutic dose.
- Trial name
- NCT06446609
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Liver Failure, Liver Failure, Acute
Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever
The purpose of this study is to compare the efficacy of the an N-acetyl-p-aminophenol (APAP, also known as acetaminophen) and N-acetylcysteine (NAC) combination versus an APAP-placebo combination as an anti-pyretic agent.
- Conditions
- Liver Failure, Liver Failure, Acute, Drug Induced Liver Injury, Prevention & Control
- Trial name
- NCT01137591
- Testing
- APAP and NAC combination
- Where
- United States
- Sponsor
- Columbia University
Drug-induced Liver Injury
Glucocorticosteroid Therapy on Drug-induced Liver Injury: a Prospective Non-randomized Concurrent Control Trial
The purpose of this study is to assess the safety and efficacy of glucocorticosteroid for treatment of drug-induced liver injury.
- Trial name
- NCT04553003
- Testing
- Glucocorticoids+hepatoprotectant, hepatoprotectant
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Li Yang
Pulmonary Tuberculosis
Efficacy of HUEXC030 in Subjects With Pulmonary Tuberculosis
Assess the Efficacy of HUEXC030 as Add-on Excipient to Eradicate Anti-Tuberculosis Drugs Induced Hepatic Injury ( ATDH ) in Subjects with Pulmonary Tuberculosis
- Trial name
- NCT02467608
- Testing
- Isoniazid with HUEXC030 and RZE, HRZE
- Where
- 18 sites in Taiwan
- Volunteers
- 557 people
- Sponsor
- Orient Pharma Co., Ltd.
Drug-induced Liver Injury,Chronic
36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI
This study is to observe the efficacy and safety of 36 weeks short-term optimization treatment of glucocorticosteroid in the patients with chronic recurrent drug-induced liver injury (DILI).
- Trial name
- NCT03266146
- Testing
- 36 Weeks Methylprednisolone, 48 weeks Methylprednisolone
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing 302 Hospital
Healthy
A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)
This study has an open-label, one-sequence, multiple drug administration design. The purpose of this study is as follows; To evaluate the change of liver function according to glutathione s-transferase (GST) genotype after the…
- Trial name
- NCT02143323
- Testing
- Augmentin tablet
- Where
- 2 sites in South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cannabidiol, Drug Induced Liver Injury
Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
Cannabidiol (CBD) is available as a prescription drug product for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex.
- Conditions
- Cannabidiol, Drug Induced Liver Injury, Drug Interaction
- Trial name
- NCT06192589
- Testing
- Cannabidiol, Citalopram, Morphine
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Drug Induced Liver Injury, Tuberculosis (TB)
Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi
OBJECTIVE : To compare the outcome of treatment with silymarin or N-acetyl cysteine in patients taking anti-tuberculous drugs for tuberculosis at Tertiary Care Hospital, Karachi.
- Trial name
- NCT07058090
- Testing
- Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
- Volunteers
- 410 people
- Sponsor
- Liaquat National Hospital & Medical College
Drug-induced Liver Injury
A Prognostic Model for Drug-induced Liver Injury in China
A prospective, multi-center, non-interventional cohort study is going to conduct to explore the clinical characteristics, culprit drug(s) or herb(s), outcomes and risk factors of Drug-induced liver injury (DILI) in China and…
- Trial name
- DILI-PM (NCT05060289)
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Drug Induced Liver Injury
Prospective Comparative Validation Study of RUCAM and RECAM
A total of 407 hospitalized patients with acute liver injury in Beijing Friendship Hospital Affiliated to Capital Medical University were enrolled.
- Trial name
- NCT06771011
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Beijing Friendship Hospital
HIV, Tuberculosis
Preliminary Evaluation of a Point-Of-Care Liver Function Test
The proposed preliminary field evaluation will compare a point-of-care (POC) transaminase test with the standard of care test used in an HIV clinic at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.
- Conditions
- HIV, Tuberculosis, Drug-Induced Liver Injury
- Trial name
- DFA (NCT01705041)
- Testing
- Diagnostics for All liver function test (LFT)
- Where
- Vietnam
- Volunteers
- 700 people
- Sponsor
- PATH