Clinical trials: Liver Regeneration
Liver Insufficiency
Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors
The PI will study metabolism during liver regeneration in living liver donors
- Trial name
- NCT01922323
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Liver Regeneration, Liver Cancer
ARAPS Study on Accelerated Liver Regeneration
Liver resection is the golden standard in the treatment of hepatic malignancies. The size and function of the remnant liver is a major concern.
- Conditions
- Liver Regeneration, Liver Cancer, Liver Metastases, Liver Failure
- Trial name
- ARAPS (NCT04107324)
- Testing
- ARAPS, PVE
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Liver Dysfunction, Morbidity
Von Willebrand Factor to Predict Postoperative Outcome
vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation.
- Conditions
- Liver Dysfunction, Morbidity, Mortality, Hospitalisation
- Trial name
- NCT02118545
- Where
- 4 sites in Austria, Switzerland
- Volunteers
- 133 people
- Sponsor
- Medical University of Vienna
Alcoholic Hepatitis
Granulocyte Colony Stimulating Factor Four Week Plus N-Acetyl Cysteine in Severe Alcoholic Hepatitis
Alcoholic hepatitis is related to very high mortality rate. About 40% of the patients died within first 6 months after the detection of the clinical syndrome.
- Trial name
- NCT05840640
- Testing
- Standard Medical Therapy, G-CSF, G-CSF and NAC
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Liver Dysfunction, Liver Metastasis Colon Cancer
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy.
- Conditions
- Liver Dysfunction, Liver Metastasis Colon Cancer, Liver Regeneration
- Trial name
- NCT06126419
- Testing
- High-Dose Insulin Therapy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Regeneration
Study of the Protective Effect of Mechanism of Pentoxyfilline After Major Liver Resection Under Inflow Occlusion (Pringle Manoeuvre)
The investigators hypothecate that pentoxyfilline increase significantly the liver regeneration and reduces significantly ischemia and reperfusion (I/R) injury in major liver using aspartate aminotransferase (AST) and alanine…
- Trial name
- NCT00957619
- Testing
- pentoxyfilline
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Complication, Postoperative, Regeneration Liver
Randomized Controlled Trial to Study the Outcome of Intravenous Phosphate Supplementation in Live Donors Undergoing Hepatectomy for Living Donor Liver Transplantation (LDLT)
In this study, we aim to analyse the effect of phosphate supplementation on donors undergoing partial hepatectomy for LDLT. In Group A, we are going to supplement phosphate in donors postoperatively from day 1 to day 5.
- Trial name
- NCT04026438
- Testing
- Potassium Phosphate Injection
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cancer
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
The study will monitor carbon monoxide production in patients undergoing liver resection. Carbon monoxide will be checked from arterial blood gas obtained routinely as a part of the postoperative care as well as from the exhaled…
- Trial name
- NCT04195438
- Testing
- CO Testing Pre/Post Hepatic Resection, ABG Testing Pre/Post Hepatic Resection, CT Evaluations
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Maryland, Baltimore
Liver Cancer Adult, Liver Regeneration
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO…
- Trial name
- NCT06681818
- Testing
- carbon monoxide measurement via smokerlyzer
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Englewood Hospital and Medical Center
Liver Regeneration, Reversible Portal Vein Embolization
Reversible Portal Vein Embolization Before Major Hepatectomy
The aim of this study is to prospectively evaluate the tolerance and efficiency of a new technique of preoperative selective portal vein embolization (PVE) in patients requiring major hepatic resection.
- Trial name
- EMBORES (NCT02945059)
- Testing
- Selective reversible portal vein embolization
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Regeneration
Safety Study of Liver Regeneration Therapy Using Cultured Autologous BMSCs
Patients eligible for this study include those with decompensated liver cirrhosis with a Child-Pugh score ≥7 (Child-Pugh B) in whom further improvement with current medical treatment is not expected.
- Trial name
- NCT02327832
- Testing
- Autologous BMSCs, bone marrow-derived mesenchymal stem cells
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Yamaguchi University Hospital
Chronic Liver Disease
Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients
Loss of muscle mass (sarcopenia) is a major complication in a patient with cirrhosis, impacting the disease outcome, quality of life and survival.
- Trial name
- BCAA-CLD (NCT04246918)
- Testing
- Branched Chain Amino Acid, Whey Protein concentrate powder
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Diseases, Hepatectomy
Liver Regeneration After Liver Resection
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy.
- Trial name
- NCT01220986
- Testing
- Liver biopsy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Hepato Cellular Carcinoma (HCC), Hepatobiliary Cancers
Effect and Mechanism of ALPPS Operation on Liver Regeneration
Hepatobiliary malignancies-principally hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA)-are highly aggressive and often diagnosed at advanced stages.
- Conditions
- Hepato Cellular Carcinoma (HCC), Hepatobiliary Cancers, Liver Cancer, Liver Regeneration
- Trial name
- NCT07142213
- Testing
- ALPPS
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Haitao Zhao, MD
Liver Regeneration
Effect of Novel Donor Lifestyle Optimisation Protocol on Liver Regeneration in Live Liver Donors
Steatosis in case of live liver donors is on the rise and around 20- 40 % of prospective liver donors are estimated to have hepatic steatosis.
- Trial name
- NCT04565535
- Testing
- Novel donor lifestyle optimisation protocol
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Mediators of Post Hepatectomy Liver Regeneration
Study of Mediators of Post Hepatectomy Liver Regeneration
Prospective non-randomized trial to study expression of mediators of post hepatectomy liver regeneration (PHLR) and compare with a non-hepatectomy group: a pilot study Background : Experimental studies using post hepatectomy…
- Trial name
- NCT02077062
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Govind Ballabh Pant Hospital
Liver Cirrhosis
Evaluation of Liver Regeneration With Autologous Peripheral Stem Cells
For patient with liver cirrhosis who need to right or extended right hepatectomy, we will treat with autologous peripheral stem cells transplantation to facilitate liver regeneration.
- Trial name
- NCT01108380
- Testing
- Plasma pheresis, Right portal vein embolization
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Liver Failure, Acute, Liver Failure, Acute on Chronic
HEpatic Regeneration With COupled Plasma Filtration and Adsorption for Liver Extracorporeal Detoxification
CPFA is currently used in the treatment of severe sepsis with the intention of removing the proinflammatory mediators from the systemic circulation.
- Trial name
- HERCOLE (NCT03312036)
- Testing
- Coupled plasma filtration and adsorption (CPFA)
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Primary Liver Cancer, Hepatocellular Carcinoma (HCC)
The Dragon PLC Trial (DRAGON-PLC)
The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable…
- Conditions
- Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
- Trial name
- NCT06914648
- Testing
- Portal Vein Embolization, Hepatic Vein Embolization
- Where
- 55 sites in United States, Australia and 10 more
- Volunteers
- 358 people
- Sponsor
- Maastricht University
Hepatorenal Syndrome, Liver Regeneration
Plasma and Hemodynamic Markers During Hepatectomy
Introduction Liver resection is considered the only curative treatment option for mCRC patients without extrahepatic disease and is accepted practice.
- Trial name
- NCT01700231
- Testing
- Liver resection
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna