Clinical trials: Liver Transplant
Liver Transplantation, Recipients of Liver Transplant
External Oblique Intercostal Plane Block for Liver Transplantation Recipient
Postoperative pain management is one of the key factors in improving rehabilitation and accelerating recovery. The external oblique intercostal plane block can be used to provide abdominal wall analgesia for effective pain…
- Conditions
- Liver Transplantation, Recipients of Liver Transplant, Postoperative Pain
- Trial name
- NCT07233083
- Testing
- External Oblique Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
Immune Function in Blood, Liver Function in Blood
Autologous Mesenchymal Stem Cell Transplantation in Cirrhosis Patients With Refractory Ascites
Liver cirrhosis (LC) is the final destiny in chronic liver disease.The quality of life in liver cirrhosis patients with refractory ascites are very wretched.
- Conditions
- Immune Function in Blood, Liver Function in Blood, Variation of Ascites, Characters of Quality of Life
- Trial name
- NCT01854125
- Testing
- autologous bone marrow mesenchymal stem cells transplantation, autologous bone marrow msenchymal stem cells transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing PLA General Hospital
Massive Transfusion, Trauma
Australian and New Zealand Massive Transfusion Registry
Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies.
- Conditions
- Massive Transfusion, Trauma, Cardiothoracic Surgery, Gastrointestinal Bleeding
- Trial name
- ANZ-MTR (NCT02863250)
- Where
- Australia
- Volunteers
- 50,000 people
- Sponsor
- Monash University
Hepatitis B, Chronic (CHB), Hepatitis B
Real-world Study Evaluating the Long-term Outcomes of Pegylated Interferon α-2b Treatment in the Families With Clusters of HBV Infection and Unfavorable Prognosis - A Prospective, Controlled, Multicenter, Cohort Study
Chronic hepatitis B can develop into cirrhosis and liver cancer, which seriously endangers the life and health of people. In China, HBV is mainly transmitted from mother to child, showing the phenomenon of family clusters.
- Conditions
- Hepatitis B, Chronic (CHB), Hepatitis B, Hepatitis B Virus (HBV)
- Trial name
- NCT07079150
- Testing
- Peg IFN-α-2b
- Where
- 2 sites in China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Non-alcoholic Fatty Liver Disease
Non-invasive Diagnosis of Non-alcoholic Steatohepatitis in Liver Transplant Recipients
The purpose of this study is is to use non-invasive diagnostic tests, Fibroscan and a simple blood test, to diagnose NASH in patients who undergo liver transplantation.
- Trial name
- NCT03128918
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Transplanted Patients
Early Rehabilitation Program is Feasible and Safe in ICU in Liver Transplanted Patients
Liver transplantation is the last surgical treatment for patients with acute or chronic liver disease. Transplantation therapies technics are in constant evolution.
- Trial name
- NCT01960868
- Testing
- standard physiotherapy, experimental physical therapy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Fibrolamellar Hepatocellular Carcinoma, Hepatocellular Carcinoma (Fibrolamellar Variant)
Sequential, Related Donor Partial Liver Transplantation Followed by Bone Marrow Transplantation for Hepatocellular Carcinoma (HCC)
This trial is a phase II, single arm, open-label, single center study to assess a reduced-intensity conditioning regimen, bone marrow transplantation and high dose PTCy in recipients of a partial liver allograft from a Human…
- Conditions
- Fibrolamellar Hepatocellular Carcinoma, Hepatocellular Carcinoma (Fibrolamellar Variant), Hepatocellular Carcinoma
- Trial name
- NCT02702960
- Testing
- living related donor partial liver transplantation, Total body irradiation, Bone marrow transplant from same donor
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Liver Transplantation, Living Donor
Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors
Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia…
- Conditions
- Liver Transplantation, Living Donor, Postoperative Pain
- Trial name
- NCT07233096
- Testing
- Rectus Intercostal Plane Block, Control (No Block)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
Living-donor Liver Transplantation
Induction of Transplant Tolerance in LDLT Via iTS
The purpose of this clinical trial is to examine the immunotolerance-inducing ability (effectiveness) of induced inhibitory T cells JB-101 in patients with living-donor liver transplantation using "whether or not operational…
- Trial name
- NCT04950842
- Testing
- JB-101
- Where
- 5 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Juntendo University
Liver Cirrhosis
Human Fetal Liver Cell Transplantation in Chronic Liver Failure
The herein study consists in the transplantation of liver progenitor cells isolated from human fetal liver tissue with the aim of improving conventional liver therapy and broadening therapeutical options other than liver…
- Trial name
- hFLCTx (NCT01013194)
- Testing
- Human Fetal Liver Cell Transplantation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Liver Transplantation
A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Liver Transplant Patients.
This 2 arm study will compare the efficacy and safety of two CellCept-containing treatment regimens in de novo liver transplant patients.
- Trial name
- NCT00545402
- Testing
- Mycophenolate mofetil, adjusted dose, Tacrolimus, Corticosteroids, IV
- Where
- 16 sites in France
- Volunteers
- 180 people
- Sponsor
- Hoffmann-La Roche
Brain Death, Liver Steatosis
"LiverColor": Machine Learning in Liver Photographs
The main goal of this project is to create a machine learning model in order to quantify liver steatosis in liver donor faster, more objective and reliable than histological analysis and surgeons point-of-view.
- Trial name
- NCT05202886
- Testing
- Liver from deceased donors
- Where
- Spain
- Volunteers
- 246 people
- Sponsor
- Hospital Vall d'Hebron
Chronic Hepatitis C, HCV
A Study to Evaluate the Safety and Efficacy of ABT-493/ABT-530 in Adult Post-Liver or Post-Renal Transplant Recipients With Chronic Hepatitis C Virus (MAGELLAN-2)
The purpose of this study is to assess the safety and efficacy of 12 weeks of treatment of ABT-493/ABT-530 (glecaprevir/pibrentasvir) in adults who are post primary orthotopic liver or renal transplant with chronic hepatitis C…
- Conditions
- Chronic Hepatitis C, HCV, Hepatitis C Virus
- Trial name
- NCT02692703
- Testing
- glecaprevir/pibrentasvir
- Volunteers
- 100 people
- Sponsor
- AbbVie
Kidney Transplant, Hepatitis C
Hepatitis C Virus Donor Positive Kidney Transplantation for Hepatitis C Virus Negative Recipients
The development of direct acting anti-virals (DAAs) for the treatment of Hepatitis C virus (HCV) has changed the landscape of HCV therapy dramatically in the last several years with reported sustained virologic response (SVR)…
- Trial name
- NCT03249194
- Testing
- Direct acting Anti-Viral Therapy using Epclusa or Zepatier
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Commonwealth University
End Stage Liver Disease, Rejection
Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant Patients
To search for suitable pharmacodynamic biomarkers, i.e., with high specificity for calcineurin inhibition and most affected by inter-individual variability, our works aimed at exploring the pharmacodynamics of CNI, the strength…
- Conditions
- End Stage Liver Disease, Rejection, Infection, Malignancy
- Trial name
- 3PIGREF (NCT01760356)
- Where
- Uruguay
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- UDA Centro Nacional Hepato-Bilio-Pancreático
Primary Sclerosing Cholangitis, Post- Orthotopic Liver Transplantation
Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients
The purpose of the study is to investigate the safety and efficacy of oral vancomycin in patients with recurrent Primary Sclerosing Cholangitis (PSC) after liver transplantation.
- Trial name
- NCT03046901
- Testing
- Vancomycin
- Where
- United States
- Sponsor
- Ochsner Health System
Acute-On-Chronic Liver Failure, Hepatic Encephalopathy
Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE
Pretransplant hepatoencephalopathy (HE) markedly impacts recipient outcomes after liver transplantation. Intraoperative CRRT showed benefits but feasibility was much concerned.
- Trial name
- LTeCRRT (NCT04317222)
- Testing
- eCRRT
- Volunteers
- 250 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Mediastinal Cancer, Metastatic Cancer
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Mediastinal Cancer, Metastatic Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00003941
- Testing
- bleomycin sulfate, filgrastim, cisplatin
- Where
- 37 sites in Austria, Belgium and 10 more
- Volunteers
- 222 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Liver Transplantation, Carbapenem-Resistant Enterobacteriaceae Colonization
Impact of a Risk Stratification Tool on the Outcome of Liver Transplant Recipients Colonized With Carbapenem Resistant Enterobacteriaceae: an Observational Study
Although CRE infection after OLT have a dramatic impact on patient survival and several implementations have been proposed (i.e.
- Trial name
- NCT05594901
- Testing
- Application of a prognostic score
- Where
- 6 sites in Brazil, Italy and 1 more
- Volunteers
- 240 people
- Sponsor
- University of Bologna
Phenylketonuria
Liver Cell Transplant for Phenylketonuria
Human phenylketonuria (PKU) results from phenylalanine hydroxylase (PAH) deficiency, and represents one of the most common and extensively studied single-gene Mendelian disorders in humans.
- Trial name
- NCT01465100
- Testing
- Preparative Radiation Therapy, Hepatocyte Transplant, Immunosuppression
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ira Fox