Clinical trials: Liver Transplant Recipients
Liver Transplantation
Withdrawal of Immunosuppression in Long Term Stable Liver Transplant Recipients
Long-term immunosuppression carries potential adverse effects such as risk of infection, malignancy, renal insufficiency, diabetes and hypertension.
- Trial name
- tolerance (NCT01198314)
- Testing
- immunosuppression withdrawal, continue of taking immunosuppressant
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Evidence of Liver Transplantation
The Study to Evaluate Efficacy and Safety of MY-REPT Capsule in Primary, Liver Transplantation Recipients (MYLT1)
Efficacy and safety of MY-REPT capsule in primary, liver transplantation recipients
- Trial name
- NCT01766518
- Testing
- Mycophenolate mofetil
- Where
- 3 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Orthotopic Liver Transplant
Everolimus Post Orthotopic Liver Transplant
The purpose of this study is to evaluate the efficacy of an everolimus conversion (EVR) protocol as compared to the standard tacrolimus (TAC) based protocol in liver transplant recipients, as determined by renal function…
- Trial name
- NCT01998789
- Testing
- Everolimus, Standard Tacrolimus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Tomoaki Kato
Liver Transplantation, Graft Failure
Immunization Anti HLA in the Liver Transplant Recipients (DSATH)
Anti HLA alloimmunization against the donor evaluated by the detection of anti-donor specific antibodies (DSA) is an underestimated factor in liver transplantation and may contribute to dysfunction and graft loss , especially…
- Trial name
- DSATH (NCT02556879)
- Testing
- Donor specific antibodies, Serum bank, DNA bank
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Indirect Calorimetry
Using Indirect Calorimetry for Liver Transplants Patients
Although predicted REE calculated using the Penn state 1988 method agreed (ICC 0.61, p=0.00014) with the measured REE, all three predictive equations had a fixed bias and appeared to be inaccurate for predicting REE for liver…
- Trial name
- NCT03622268
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Renal Failure Chronic, Hepatitis C
Multi-center Study to Transplant Hepatitis-C Infected Kidneys
Open label multi center study for the donation of HCV positive kidneys to HCV negative recipients with interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- MYTHIC (NCT03781726)
- Testing
- glecaprevir/pibrentasvir treatment
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Raymond Chung
Liver Failure
Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients
To provide proof-of-concept data on the efficacy/safety of transplanting HCV positive donor grafts in HCV sero-negative liver recipients who are currently listed.
- Trial name
- NCT03650920
- Testing
- Liver Transplantation
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Loma Linda University
Pediatric Liver Transplanted Recipients
Health Advocate for Children After Liver Transplant
The HEAL-Tx is a 90-day intervention, in which a Health Advocate works with eligible families to identify and apply for community-based resources, alert healthcare providers to challenges the family is encountering, and guide…
- Trial name
- HEAL-Tx:RCT (NCT07279350)
- Testing
- Health advocate, Enhanced Control
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Francisco
Lung Transplant Infection, Heart Transplant Infection
Transplantation Using Hepatitis C Positive Donors, A Safety Trial
The success of transplantation is significantly hindered by the lack of sufficient number of available donors. Many potential donor organs cannot be utilized in clinical transplantation because donors have chronic viral…
- Conditions
- Lung Transplant Infection, Heart Transplant Infection, Kidney Transplant Infection, Kidney Pancreas Infection
- Trial name
- NCT04017338
- Testing
- Glecaprevir 300 MG / Pibrentasvir 120 MG Oral Tablet, Ezetimibe 10Mg Oral Tablet, Ex Vivo Lung Perfusion
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Jordan Feld
Liver Transplant
Safety and Efficacy of Perioperative Remodulin® in Orthotopic Liver Transplant Recipients
Patients undergoing orthotopic liver transplant will experience some degree of clinical and/or biochemical hepatic dysfunction. This early injury is known as primary graft dysfunction and varies from minor abnormalities to…
- Trial name
- NCT01884038
- Testing
- treprostinil sodium
- Where
- United States
- Sponsor
- United Therapeutics
Liver Transplantation, Transplant Recipients
A Cohort Study on the Pathogen Spectrum of Liver Transplant Recipients Complicated With Infection
The goal of this observational study is to map the pathogen profile of secondary infections in liver transplant recipients, to correlate the basic immune status with the characteristics of the secondary infection pathogen…
- Trial name
- NCT06279884
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang University
Liver Transplant Recipients
Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea…
- Trial name
- NCT06418893
- Testing
- Target control infusion propofol, Inhalational isoflurane
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Heart Transplant Infection, Kidney Transplant Infection
CMV T Cell Immunity in Pediatric Solid Organ Transplant Recipients
CMV infection and disease remain a significant clinical challenge for pediatric solid organ transplant (SOT) recipients. Current prevention strategies are limited to prophylaxis in which antiviral medication is administered for a…
- Conditions
- Heart Transplant Infection, Kidney Transplant Infection, Liver Transplant Infection, CMV
- Trial name
- NCT03924219
- Testing
- CMV T cell Immunity Assay
- Where
- 12 sites in United States
- Volunteers
- 161 people
- Sponsor
- Vanderbilt University Medical Center
Growth, Development in Pediatric Liver Transplant Recipients
A Survey on Growth Development in Children After Liver Transplantation
A single-center, large-sample, long-term longitudinal study was conducted to explore the trends and characteristics of changes in growth, development in pediatric liver transplant recipients, with the aim of guiding the…
- Trial name
- NCT07574398
- Where
- China
- Volunteers
- 275 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma, Liver Transplantation
Research and Application for New Clinical Diagnosis and Treatment System for HBV Related HCC Liver Transplantation
The study evaluated the protein expression levels of FK506-binding protein 12 (FKBP12) in hepatocellular carcinoma (HCC) and paracancerous tissues using immunohistochemistry (IHC).
- Conditions
- Hepatocellular Carcinoma, Liver Transplantation, Prognosis
- Trial name
- NCT06409507
- Testing
- FKBP12 expression
- Volunteers
- 178 people
- Sponsor
- First People's Hospital of Hangzhou
Liver Transplantation
To Evaluate the Efficacy and Safety of ADVAGRAF® After Treatment With a Tacrolimus in New Liver Transplant Recipients
This study's objective is to evaluate the incidence rate of acute rejection reactions after 24 weeks treatment with ADVAGRAF® following 3 months treatment with tacrolimus in new liver transplant recipients.
- Trial name
- Assign (NCT04761731)
- Testing
- ADVAGRAF®
- Volunteers
- 31 people
- Sponsor
- Linical Korea
End Stage Liver Disease, Rejection
Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant Patients
To search for suitable pharmacodynamic biomarkers, i.e., with high specificity for calcineurin inhibition and most affected by inter-individual variability, our works aimed at exploring the pharmacodynamics of CNI, the strength…
- Conditions
- End Stage Liver Disease, Rejection, Infection, Malignancy
- Trial name
- 3PIGREF (NCT01760356)
- Where
- Uruguay
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- UDA Centro Nacional Hepato-Bilio-Pancreático
Preoperative Clear Fluid Fasting, Liver Transplant Recipient
"Duration of Preoperative Clear Fluids Fasting in Patients Undergoing Liver Transplant"
The goal of this prospective observational study is to report the duration of preoperative clear fluids fasting in patients undergoing liver transplant.
- Trial name
- Timbarc-1 (NCT07288281)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mayo Clinic
Liver Transplant Infection, Kidney Transplant Infection
Impact of Culture of Perfusion Fluid on Donor-derived Infection Management and Outcome in Liver and Kidney Transplant
This study aims to evaluate whether microbiological testing of the perfusion fluid used to transport transplanted organs can help predict the development of infections in liver and kidney transplant recipients, including possible…
- Conditions
- Liver Transplant Infection, Kidney Transplant Infection, Liver Transplant, Kidney Transplant
- Trial name
- PREVENT (NCT07651137)
- Where
- Italy
- Volunteers
- 1,400 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna