Clinical trials: Liver Transplant Recipients
Hepatitis C Virus Infection
Safety and Efficacy of Ledipasvir/Sofosbuvir (LDV/SOF) Fixed Dose Combination (FDC) for 12 or 24 Weeks in Kidney Transplant Recipients With Chronic HCV Infection
This study will evaluate the safety, tolerability, and antiviral efficacy of ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) for 12 or 24 weeks in adults with chronic genotype 1 or genotype 4 hepatitis C virus (HCV)…
- Trial name
- NCT02251717
- Testing
- LDV/SOF
- Where
- 5 sites in Austria, France and 2 more
- Volunteers
- 114 people
- Sponsor
- Gilead Sciences
Liver Disease
Mycophenolate Mofetil Immunosuppression Without/With Reduced Dose Calcineurin Inhibitor Long After Liver Transplantation
The purpose of the study is to assess the safety and efficacy of mycophenolate mofetil alone, or with reduced dose cyclosporine (CsA) or tacrolimus, for immunosuppression long-term after liver transplantation, in an attempt to…
- Trial name
- NCT00206076
- Testing
- mycophenolate mofetil
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- Albert Einstein Healthcare Network
Liver Transplant
Prospective, Multicenter Clinical Study of Prolonged-release Tacrolimus in Stable Pediatric Liver Transplant Recipients
This study aims to explore the effects of tacrolimus sustained-release capsules on the incidence of biopsy-proven acute rejection(BPAR) and fibrosis in pediatric liver transplant recipients.
- Trial name
- NCT06183892
- Testing
- Tacrolimus Sustained-release Capsules
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Pediatric Recipients of a Liver Transplant
Medication Adherence in Children Who Had a Liver Transplant
The purpose of this study is to evaluate the use of a novel method to measure adherence to immunosuppressant medications in predicting rejection episodes in children who had a liver transplant.
- Trial name
- MALT (NCT01154075)
- Where
- 5 sites in United States
- Volunteers
- 401 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Transplant Rejection, Immunosuppression
Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents
This study is being done with the purpose of trying to understand if and why transplant recipients may develop tolerance to their transplanted organ.
- Trial name
- NCT01678937
- Testing
- Blood Draw - Rapamycin, Blood Draw from Control Subjects, Blood Draw - CyA
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Liver Transplantation
A Study of TCD601 in the Induction of Tolerance in de Novo Liver Transplantation
The purpose of this study is to evaluate if treatment with a siplizumab-based regimen can induce allogeneic tolerance in liver transplant recipients.
- Trial name
- NCT06019507
- Testing
- TCD601, Cyclophosphamide, TAC
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- ITB-Med LLC
Liver Transplantation
A Multicenter Study Evaluating the Safety and Tolerability of Intravenous rhMBL in Liver Transplant Recipients.
This is a multicenter, open-label, randomized, Phase 1B study evaluating liver transplant recipients receiving rhMBL (2 cohorts) or without rhMBL (1 cohort).
- Trial name
- NCT00415311
- Testing
- Intravenous Recombinant Human Mannose-Binding Lectin (rhMBL)
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Enzon Pharmaceuticals, Inc.
Tacrolimus-associated Abnormal Glucose Metabolism in Kidney and Liver Transplant Recipients
Safety and Efficacy of Converting Maintenance Kidney and Liver Transplant Recipients With Abnormal Glucose Metabolism From Tacrolimus to Cyclosporine Micro-emulsion
New onset diabetes mellitus (NODM) post- transplantation decreases patient and graft survival. Some immunosuppressive agents are associated with a higher incidence of NODM.
- Trial name
- NCT00150085
- Testing
- cyclosporine micro-emulsion
- Volunteers
- 50 people
- Sponsor
- Novartis
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Immunosuppression
A Prospective Study on the Tolerability and Efficacy of the de Novo Use of Myfortic in Liver Transplant Recipients
The objective of this study is to compare the safety and efficacy of Myfortic with CellCept in liver transplant patients. Myfortic and CellCept are both immunosuppressive (anti-rejection) drugs.
- Trial name
- NCT00336817
- Testing
- Myfortic, CellCept
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients
Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors
This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors.
- Conditions
- Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients, Living Liver Donor
- Trial name
- NCT07301853
- Testing
- liver transplantation, Living Donor Hepatectomy
- Where
- China
- Volunteers
- 9,999 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Transplant, Kidney Transplant
Feasibility and Acceptability of a New Tool Promoting a Healthy Lifestyle in Liver and Kidney Transplant Recipients
This interventional clinical trial tests whether a doctor-delivered lifestyle counseling program, supported by two personalized digital tools, is feasible and helpful for improving healthy eating and physical activity in older…
- Trial name
- NCT07305012
- Testing
- Promoting a Healthy Lifestyle through Digital Support Tools (Nutrida and Gamebus)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Transplantation
Study Evaluating of Calcineurin Inhibitor and Sirolimus (Rapamune) Treatment in Liver Transplant Recipients
The purpose of this study is to evaluate the sirolimus conversion regimen as compared with the calcineurin inhibitor continuation regimen with regards to renal function in stable liver transplant subjects.
- Trial name
- NCT00086346
- Testing
- Sirolimus (Rapamune), Cyclosporine or Tacrolimus
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 607 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Liver Disease
Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus…
- Trial name
- NCT01958190
- Testing
- Tacrolimus and Sirolimus, Tacrolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Foundation for Liver Research
Ischemia Reperfusion Injury
Tacrolimus During the Implantation and the Effect on Ischemia-reperfusion Injury in Liver Transplantation
The evaluation of the efficacy of an intraportal infusion with Tacrolimus, at the time of liver graft implantation, compared to a control group without immunosuppressive intraportal infusion (Placebo: Saline solution 0.9%) with…
- Trial name
- TAC-Infusion (NCT00609388)
- Testing
- Tacrolimus, Saline solution 0.9% (250mL)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Chronic Hepatitis C, Organ Transplantation
Randomized Controlled Trial in Liver Transplant Recipients Treated in Steroid Sparing Regimen
Liver transplant subjects will be given Mycophenolate (MMF) and Tacrolimus in order to help prevent post-transplant rejection.
- Conditions
- Chronic Hepatitis C, Organ Transplantation, Immunosuppression
- Trial name
- NCT00286871
- Testing
- Neoral, Tacrolimus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Liver Transplant
A Multicentre, Randomised, Open-label, Controlled, 12-month Follow-up Study to Assess Impact on Renal Function of an Immunosuppression Regimen Based on Tacrolimus Minimisation in Association With Everolimus in de Novo Liver Transplant Recipients.
Assuming greater efficacy in the prevention of acute rejection in the EVR arm with minimisation of TAC levels, the hypothesis of the present trial was that the introduction of EVR in combination with the minimisation of TAC…
- Trial name
- REDUCE (NCT02040584)
- Testing
- Minimisation of TAC, TAC + MMF + corticosteroids
- Where
- 20 sites in Spain
- Volunteers
- 217 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplantation (LT), End-Stage Liver Disease
Physical and Cognitive Outcomes After Post-Transplant Physiotherapy in Liver Transplant Recipients
Liver transplantation is the most effective treatment for end-stage liver disease. However, many recipients continue to experience problems such as reduced physical function, impaired balance, fatigue, and cognitive difficulties…
- Trial name
- NCT07694245
- Testing
- Routine Post-Transplant Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Hasan Kalyoncu University
Liver Transplant, Hepatitis C
The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients
This is an open-label, pilot trial to test the safety and efficacy of transplantation of livers from Hepatitis C seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative…
- Trial name
- NCT03819322
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Fernanda P Silveira, MD, MS
The Recipients Undergoing Liver Transplantation
Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
- Trial name
- NCT03344380
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University