Clinical trials: Liver Transplant Recipients
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Pediatric Acute Respiratory Distress Syndrome, Desflurane
Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients
Biliary atresia is a serious congenital anomaly characterized by persistent and progressive cholestatic jaundice. The incidence of biliary atresia is more common in East Asia, especially China, with an incidence of 2 per 10,000…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome, Desflurane, Biliary Atresia
- Trial name
- EDPARDSLDLTR (NCT05783518)
- Testing
- desflurane, propofol
- Where
- 2 sites in China
- Volunteers
- 165 people
- Sponsor
- Tianjin First Central Hospital
Liver Transplant Recipient
Extension Study to Evaluate the Long-term Efficacy and Safety of Everolimus in Liver Transplant Recipients
The reason for this extension is to evaluate the long-term safety and efficacy of two concentration-controlled everolimus regimen in de novo liver transplant recipients.
- Trial name
- NCT01150097
- Testing
- Tacrolimus (reduced tacrolimus), Everolimus (reduced tacrolimus), Tacrolimus (tacrolimus elimination)
- Where
- 57 sites in United States, Argentina and 14 more
- Volunteers
- 284 people
- Sponsor
- Novartis Pharmaceuticals
Cytomegalovirus, Organ Transplant
Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)
This study is being done to find out if administering CytoGam® after the end of standardly prescribed preventive antiviral treatment can help transplant recipients with a high risk for developing late CMV disease after a liver…
- Conditions
- Cytomegalovirus, Organ Transplant, Kidney Transplant; Complications, Liver Transplant Complications
- Trial name
- SHIELD (NCT06958796)
- Testing
- Cytomegalovirus Immune Globulin Intravenous (Human) monthly for three months
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Camille N. Kotton, MD
Renal Insufficiency
Safety Use of ATeGe in Liver Transplant Recipients With Pre-transplant Renal Dysfunction
Renal dysfunction in the context of liver transplantation is a major issue, with difficult patients' management and determining a worsened prognosis.
- Trial name
- ATG_HVH (NCT01453218)
- Testing
- ATeGe-Fresenius
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Vall d'Hebron
Kidney Failure, Hepatitis C
HCV + to HCV - Kidney Transplant
This is a single center study characterizing the experience of administration of 8 weeks of pan-genotypic DAA therapy in kidney transplantation to prevent the transmission of hepatitis C virus infection from an HCV-positive donor…
- Trial name
- NCT04320290
- Testing
- Direct Acting Antivirals
- Sponsor
- Massachusetts General Hospital
Immunosuppression
Conversion of CellCept to Myfortic: A Prospective Study in Liver Transplant Recipients
The objective of this study is to determine the tolerability and safety of Myfortic in liver transplant patients. Patients receiving CellCept who have GI side effects will have CellCept discontinued and changed to Myfortic…
- Trial name
- NCT00336895
- Testing
- Myfortic
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pittsburgh
Liver Transplantation
Measurement of Gastrointestinal (GI) and Health-related Quality of Life (HRQL) Outcomes in Liver Transplant Recipients
Treatment with the immunosuppressive drug mycophenolate mofetil (MMF) may result in gastrointestinal (GI) complications in some patients.
- Trial name
- NCT00405652
- Testing
- Enteric-coated Mycophenolate sodium (EC-MPS)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplant
Efficacy and Safety of Cyclosporine Microemulsion Given Once a Day in Adult Stable Liver Transplant Recipients
The purpose of this study is to determine whether cyclosporine microemulsion given once a day instead of twice a day benefits kidney function, blood pressure, lipid profile and glucose control in stable liver transplant…
- Trial name
- NCT00171509
- Testing
- Cyclosporine microemulsion
- Volunteers
- 61 people
- Sponsor
- Novartis
Fungemia, Mycoses
Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients
The aim of the study is to determine viable use of caspofungin in post-OLTx patients, and to demonstrate in particular the effectiveness, understood as the ability to reduce the incidence of invasive fungal infections, and to…
- Trial name
- CPHRLTX (NCT01260974)
- Testing
- Caspofungin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Ospedaliera di Padova
Liver Transplant Disorder, Self Efficacy
Effectiveness of Intelligent Case Manage Platform in Liver Transplant Recipients
This study is a prospective, quasi-experimental design, with an experimental group and a control group, will be created. The aims of this study are as follows: 1.
- Conditions
- Liver Transplant Disorder, Self Efficacy, Quality of Life
- Trial name
- ICMP (NCT05953948)
- Testing
- Intelligent Case Manage Platform (ICMP) and self-management program
- Where
- Taiwan
- Volunteers
- 333 people
- Sponsor
- Chang Gung University
Liver Dysfunction
Influence of CYP3A5 Polymorphism on Liver Function Abnormality and the Trough Level Change After Conversion
This study is a multicenter, single-arm, open-label, 24 weeks, and investigator-initiated clinical trial to assess the influence of CYP3A5 polymorphism on liver function abnormality and the trough level change after conversion to…
- Trial name
- NCT02882113
- Testing
- Advagraf
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Liver Disease
Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus…
- Trial name
- NCT01958190
- Testing
- Tacrolimus and Sirolimus, Tacrolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Foundation for Liver Research
HBV, Kidney Transplantation
Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
Solid Organ Transplantation (SOT) is made possible by the use of a lifelong immunosuppressive treatment. This treatment limits the response of the immune system, enabling long-term survival of the transplanted organ, but also…
- Conditions
- HBV, Kidney Transplantation, Liver Transplantation
- Trial name
- VITAMIN (NCT06307808)
- Testing
- Tacrolimus, Belatacept
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Living Donor Liver Transplantation Recipients
Pressure Controlled Versus Volume Controlled Mechanical Ventilation During Anesthesia for Living Donor Liver Transplantation Recipients
pressure controlled ventilation will improve oxygenation indices , hemodynamics during anesthesia for living donor liver transplantation recipients ,improving postoperative graft function and decreasing postoperative pulmonary…
- Trial name
- NCT01865019
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Liver Transplant Rejection, Immune System Suppression
Conversion of Maintenance Prograf to Envarsus in Liver Transplant Recipients
Prograf and Envarsus are two different formulations of Tacrolimus which is used as an immunosuppressant in liver transplant (LT) patients.
- Trial name
- NCT05655273
- Testing
- Prograf, Envarsus
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Porto-Sinusoidal Vascular Disease
Risk Factors for Portosinusoidal Vascular Disease in Kidney Transplant Recipients:
To look for the factors of exposure present prior to the onset of Porto-Sinusoidal Vascular Disease (PSVD) and which can lead to the occurrence of PSVD after renal transplantation, and therefore to consider the identification of…
- Trial name
- TRANSVAS (NCT05388409)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Pulmonary Veno-Occlusive Disease, Hepatic Veno-Occlusive Disease
Effects on Glutamine on the Outcome of Allogeneic Bone Marrow Transplant Recipients
The primary purpose of this project is to investigate if addition of glutamine, an amino acid, to standard parenteral nutrition, may improve the clinical outcome of the bone marrrow transplantation reducing the occurrence of…
- Conditions
- Pulmonary Veno-Occlusive Disease, Hepatic Veno-Occlusive Disease, Mucositis
- Trial name
- NCT00563498
- Testing
- Glutamine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Hospital Authority, Hong Kong
End Stage Liver Disease
Psychosocial Risks in Liver Transplant Recipients
A retrospective chart review in which the information in the standard psychosocial evaluations done pre-transplant for liver transplant recipients will be coded, recorded, and correlated with posttransplant outcomes of the same…
- Trial name
- NCT02826460
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Icahn School of Medicine at Mount Sinai