Clinical trials: Liver Transplant Recipients
Tacrolimus-associated Abnormal Glucose Metabolism in Kidney and Liver Transplant Recipients
Safety and Efficacy of Converting Maintenance Kidney and Liver Transplant Recipients With Abnormal Glucose Metabolism From Tacrolimus to Cyclosporine Micro-emulsion
New onset diabetes mellitus (NODM) post- transplantation decreases patient and graft survival. Some immunosuppressive agents are associated with a higher incidence of NODM.
- Trial name
- NCT00150085
- Testing
- cyclosporine micro-emulsion
- Volunteers
- 50 people
- Sponsor
- Novartis
Liver Transplantation
Effect of Rapid Transfusion With Fluid Management System 2000® (FMS)
Rapid infusion of red blood cells is known to result in the increase of plasma potassium. The researchers are trying to investigate the change in plasma potassium during rapid infusion of mixed blood components in the reservoir…
- Trial name
- FMS (NCT01448343)
- Testing
- Fluid management system 2000 (FMS)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Liver Transplant; Complications, Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient
Ischemia and reperfusion injury is unavoidable during a liver transplantation. Remote ischemic preconditioning, a safe and feasible method, has previously been shown to reduce ischemia and reperfusion injury.
- Trial name
- NCT03758352
- Testing
- remote ischemic preconditioning (rIC), non remote ischemic preconditioning (non-rIC)
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hepatitis C, Hepatitis C Virus Infection, Response to Therapy of
Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor
This trial will be done in participants who undergo transplantation of heart, kidney or lung at University of California, San Diego (UCSD) and receive a hepatitis C infected donor organ.
- Trial name
- NCT04596475
- Testing
- glecaprevir/pibrentasvir (GLE/PIB)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Blood Concentration of Tacrolimus Metabolites
Dosage of Tacrolimus Metabolites in Blood and Bile for Prediction of Its Side Effects in Liver Transplant Recipients
The purpose of this study is to evaluate if concentration of tacrolimus metabolites is increased in patients presenting tacrolimus (TAC) side effects.
- Trial name
- STABILE 2 (NCT05277792)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital
Kidney Transplant Recipients, Liver Transplant Recipients
COVID Protection After Transplant-Immunosuppression Reduction
This study will enroll individuals who have: Completed primary series of mRNA COVID-19 vaccine, and An antibody response ≤ 2500 U/mL measured at least 30 days after the last dose of vaccine.
- Trial name
- CPAT-ISR (NCT05077254)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine 2023-2024, Moderna COVID-19 Vaccine 2023-2024, SOC IS Regimen
- Where
- 15 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Liver Transplantation
Data Collection Study From Donors and Recipients to Optimize Donor-recipient Matching in Liver Transplantation
A major limitation of liver transplantation is organ shortage. To avoid exposing patients to death on the waiting list, organs are used that would have been discarded few years ago.
- Trial name
- OPTIMATCH-LT (NCT03371264)
- Volunteers
- 9,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preoperative Clear Fluid Fasting, Liver Transplant Recipient
"Duration of Preoperative Clear Fluids Fasting in Patients Undergoing Liver Transplant"
The goal of this prospective observational study is to report the duration of preoperative clear fluids fasting in patients undergoing liver transplant.
- Trial name
- Timbarc-1 (NCT07288281)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Liver Transplantation
Effect of Ramadan Fasting on Muslim Recipients After Living Donor Liver Transplantation
The study aimed to assess the possibility of Ramadan fasting and to start protocol of adapting immunosupression regiment and scheduled follow up for patients wishing to fast after liver transplantation (LT).
- Trial name
- NCT03592524
- Testing
- Fasting Ramadan
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Fungemia, Mycoses
Voriconazole as Prophylaxis for Liver Transplant Recipients
The study aims to determine if voriconazole prevents invasive fungal infections in liver transplant recipients. Endpoints would be: occurrence of invasive fungal infection and fungal colonization.
- Trial name
- NCT00177788
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Pittsburgh
Infections
The Effect of PHGG-rich Enteral Nutrition to on the Infection in Liver Transplant Recipients: A Prospective, Double-blind, Randomized Controlled Study
To known the effect of PHGG-rich enteral nutrition to on the infection in liver transplant recipients
- Trial name
- NCT05543226
- Testing
- PHGG-rich enteral nutrtiion
- Volunteers
- 136 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breathing, Mouth, Muscle Relaxation
Comparison of Breathing Yoga and Progressive Muscle Relaxation Techniques After Transplantation
The study aims to compare the effectiveness of breathing yoga and progressive muscle relaxation techniques in relieving pain, respiratory complications and kinesiophobia in liver transplant recipients.
- Conditions
- Breathing, Mouth, Muscle Relaxation, Pain, Postoperative, Kinesiophobia
- Trial name
- NCT07066384
- Testing
- breathing yoga, PMRTs-Progressive Muscle Relaxation Techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Bitlis Eren University
HBV, Liver Transplant Disorder
Tenofovir Alafenamide for HBV Prophylaxis in HBV(-) Liver Transplant Recipients With HBcAb+ Donors
Liver transplantation is currently the only effective way to treat end-stage liver disease.The shortage of donor liver is still the major problem. Incidence of HBcAb+ varies between different regions.
- Trial name
- NCT04703465
- Testing
- Tenofovir Alafenamide 25 MG
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Liver Transplant, Erector Spina Plan Block
Perioperative Analgesia With Erector Spinae Plane Block in Liver Transplant Recipients
The goal of this clinical trial is to learn if ESP block is safe and effective for perioperative analgesia in patients undergoing liver transplant.
- Trial name
- NCT06857331
- Testing
- Erector Spinae Plane Block using 0.2% ropivacaine
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Bogomolets National Medical University
Pediatric Recipients of a Liver Transplant
Medication Adherence in Children Who Had a Liver Transplant
The purpose of this study is to evaluate the use of a novel method to measure adherence to immunosuppressant medications in predicting rejection episodes in children who had a liver transplant.
- Trial name
- MALT (NCT01154075)
- Where
- 5 sites in United States
- Volunteers
- 401 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcohol Associated Liver Disease, Liver Transplantation
ADDICTOlogical Intervention in LIVEr Transplantation Recipients
Transplantation for end-stage-liver disease (ESLD) in the context of Alcohol-Associated Liver Disease (AALD) has been increasing and represents the main indication for Liver Transplantation (LT) in the world.
- Trial name
- AddictoLIVE (NCT06472973)
- Testing
- Post-transplant addiction intervention
- Where
- 16 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Montpellier
Hepatitis C
Orthotopic Liver Transplant (OLT) Recipients With Hepatitis C Virus (HCV) Under Preemptive Treatment
After a liver transplant, the hepatitis C virus (which destroyed one's own liver) eventually comes back. In many patients, this will eventually cause the loss of the new liver and can also confuse the doctors taking care of them…
- Trial name
- NCT00167557
- Testing
- Pegylated Interferon, Ribavirin, Liver Biopsy
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Patients Cannulated With Both PICC and CICC., The Rapidly Fluctuating Hemodynamics During LT.
Comparison of Central Venous Pressures (CVPs) Measured From Peripherally Inserted Central Catheters (PICC) and CICC in Liver Transplantation Recipients
Background: Central venous pressure (CVP) monitoring from the peripherally inserted central venous catheter (PICC) has not often been used because of the higher inherent resistance of the PICC due to its longer length and…
- Trial name
- PICC (NCT00988871)
- Testing
- PICC, CICC
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- National Cancer Center, Korea
Liver Transplantation
A Study of Patient Adherence and Convenience to Immunosuppressive Agents in Newly Liver Transplant
A study of patient adherence and convenience to immunosuppressive agents in newly liver transplant recipients - a prospective, multi-center, open-labeled, randomized clinical trial for comparison between once-daily early…
- Trial name
- NCT03216447
- Testing
- Advagraf, Prograf
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital