Clinical trials: Liver Transplants
Liver Transplantation
Intact Liver Innervation and Glucose and Glucagon-like Peptide-1 (GLP-1) Induced Insulin Secretion
The aim of the study is to investigate the significance of intact nerve supply to the liver for the glucagon-like peptide-1 (GLP-1) induced insulin secretion.
- Trial name
- NCT01176708
- Testing
- dipeptidyl peptidase 4 (DPP4) inhibitor, oral glucose, intravenous glucose
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Postoperative Pain
Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation
The aim of study is to assess the effect of intraoperative use of magnesium sulfate in liver donating patients in reducing post-operative morphine requirements in early postoperative 24 hour in adult living liver donor.The…
- Trial name
- NCT03717467
- Testing
- isotonic saline, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Liver Transplant; Complications, Infections
Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients
In our study, some inflammatory Interleukin-2 , Interleukin-6, Interferon-γ, Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed On Myeloid…
- Conditions
- Liver Transplant; Complications, Infections, Gene Amplification, Immune Response
- Trial name
- NCT05852964
- Testing
- Molecular Immunology , gene expressions
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplant Disorder
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
- Trial name
- NCT04031924
- Testing
- Assessment of: 1. Functional Capacity 2. Physical Fitness 3. Physical Activity Level 4. Balance 5. Kinesiophobia 6. Psychological Status 7. Fatigue Severity
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Diabetes Mellitus, Type 2, Glucose, High Blood
The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients
It is believed that important brain centers send signals through the vagus nerve to the liver to suppress the amount of glucose (sugar) that gets produced.
- Conditions
- Diabetes Mellitus, Type 2, Glucose, High Blood, Glucose Metabolism Disorders
- Trial name
- NCT03685773
- Testing
- Diazoxide, Nicotinic acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Liver Failure
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant
The purpose of this study is evaluate the medication vasopressin for its ability to preserve kidney function in patients undergoing liver transplantation.
- Trial name
- NCT00886262
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Influenza
Influenza Vaccine in Pediatric Transplant Subjects
The purpose of this study is to evaluate how well children responds to the recommended trivalent subviron influenza vaccine (flu shot).
- Trial name
- NCT00133510
- Testing
- Trivalent Subviron Influenza vaccine (Fluzone)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Alcohol Use Disorder, Alcohol; Liver
CM for Patients With ALD After Liver Transplant
Alcohol associated liver disease (ALD) refers to liver injury, such as cirrhosis, that is caused by alcohol use. It affects 2 million adults in the U.S.
- Conditions
- Alcohol Use Disorder, Alcohol; Liver, Post Liver Transplant, Contingency Management
- Trial name
- NCT06304467
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Arpan A. Patel, MD
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Liver Transplantation, Comorbidities and Coexisting Conditions
The Danish Comorbidity in Liver Transplant Recipients Study
Background: Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive drugs.
- Trial name
- DACOLT (NCT04777032)
- Where
- 4 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gadolinium Toxicity
In Vitro Study of the Effect of Gadolinium Contrast on Fibrocytes
Gadolinium contrast agents are frequently administered for MRI imaging. Very little is known of its toxicity outside of patients with reduced renal function.
- Trial name
- NCT02512796
- Testing
- Gadolinium contrast dye
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
MRI Scans
Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy
The overall goal of this research is to help develop a new magnetic resonance (MR) method, Quantitative Susceptibility Mapping (QSM), to improve the measurement of liver iron concentrations without the need for a liver biopsy.
- Trial name
- NCT04171635
- Testing
- Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI), R2* Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Liver Transplant Recipients
Blood Draw Study for Liver Transplant Patients
The purpose of this study is to see what a lab test will show and if there is a way to predict which patients will be more likely to have rejection after receiving a liver transplant.
- Trial name
- NCT01525797
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Liver Transplant, Hemorrhage, Surgical
Platelet Count and Function After Usage of Two Different Cell Saver Devices During Liver Transplant Surgery
Intraoperative cell salvage is commonly used in surgeries that carry a major hemorrhagic risk to reduce the administration of allogeneic red blood cells and thus improve the outcome for the patient.
- Trial name
- PLFLTS (NCT06357455)
- Testing
- Cell Salvage Autotransfusion: SAME™ device, Cell Salvage Autotransfusion: Autolog™ device
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eduardo Schiffer
Acute Kidney Injury, Liver Disease
Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant
To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters.
- Conditions
- Acute Kidney Injury, Liver Disease, Chronic Kidney Disease, End Stage Kidney Disease
- Trial name
- NCT01619449
- Testing
- Renal replacement therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Diagnostic Techniques, Ophthalmological, Liver Transplantation
Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics.
- Conditions
- Diagnostic Techniques, Ophthalmological, Liver Transplantation, Liver Cirrhoses
- Trial name
- NCT06756009
- Testing
- Ophthalmic examination, General Condition Examination
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Hepatic Failure, Liver Failure
Cardiox Liver Function Test Pivotal Trial
Performance evaluation of LFT Dye Monitor System using ICG - plasma disappearance rate value (PDR) to assess liver function in normal patients as well as in patients with mild to severe hepatic impairment compared to manual Serum…
- Trial name
- LFT-0002 (NCT02552901)
- Testing
- 0.1 mg/kg ICG Dose, 0.5 mg/kg ICG dose
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cardiox Corporation
Liver Cirrhosis
Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation
The purpose of this study is to determine lipid metabolism in chronic liver disease in the attempt to find a useful biomarker of liver function and of prognostic value of graft function in those patients who undergo liver…
- Trial name
- NCT01389115
- Where
- 3 sites in Italy
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Liver Transplant Disorder
the Intensive Care Unit Diary for Liver Transplant Recipients
the purpose of this study is to assess the effectiveness of the intensive care unit diary for intensive care unit liver transplant recipients.
- Trial name
- NCT06356532
- Testing
- intensive care unit diary
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital