Clinical trials: Liver Transplants
Cirrhosis
Assessment of Endothelial Function, Apolipoproteins and Adiponectin
The overall hypothesis is that endothelial function, apolipoprotein levels and adiponectin levels are accurate predictors of underlying cardiovascular disease in patients with end-stage liver disease, in whom standard tools for…
- Trial name
- Endo-PAT (NCT01300390)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
HIV, Awaiting Organ Transplant
HIV-to-HIV Transplant at MGH
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice.
- Trial name
- NCT02750397
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Evidence of Liver Transplantation
Safety, Efficacy of Eglandin® in Living Donor Liver Transplanted Patient (PROVISION)
The purpose of this study is to evaluate superiority of Eglandin® (Alprostadil) 720㎍compared to 360㎍ in terms of safety, efficacy in living donor liver transplant patient, peak AST levels followed by Eglandin administration were…
- Trial name
- PROVISION (NCT02350218)
- Testing
- Eglandin
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Cryptogenic Cirrhosis, Cryptogenic Chronic Hepatitis
Bartonella in Liver Transplant Patients
Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood, skin and urine samples will be analyzed for Bartonella spp..
- Trial name
- NCT02595710
- Testing
- skin punch biopsy collection, Blood collection, Urine sample collection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Acute Graft Rejection
Diagnosis of Graft Pathology by TruGraf
The goal of this observational study is to to identify different causes of liver diseases or damage in liver transplant patients and develop a machine learning algorithm as a non-invasive tool leveraging gene expression and…
- Trial name
- NCT06557564
- Testing
- TruGraf liver gene expression
- Where
- Canada
- Volunteers
- 471 people
- Sponsor
- University Health Network, Toronto
Liver Disease
Effect of Synbiotic on Postoperative Complications After Liver Transplantation
The purpose of this study is to evaluate the use of synbiotic in patients after liver transplantation and assess the effect of these agents on postoperative infections, antibiotic use, length of hospital stay, mortality and…
- Trial name
- NCT02938871
- Testing
- Synbiotic, Control
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Liver Transplant; Complications, Vitamin D Deficiency
Relationship Between Serum Vitamin D and Outcomes of Liver Transplantation in Cirrhotic Patients Undergoing Liver Transplantation and Effects of Vitamin D Supplementation in Post-transplant Period
The study population is patients with liver cirrhosis undergoing liver transplantation; In this study, the sample will be selected from cirrhosis patients undergoing liver transplantation in Taleghani (Tehran), Imam Khomeini…
- Trial name
- NCT05568836
- Testing
- vitamin D supplementation, control
- Volunteers
- 42 people
- Sponsor
- National Nutrition and Food Technology Institute
Liver Transplantation
Investigation of the Effects of Motor Cognitive Dual Task Exercises on Cognitive Function, Balance and Functional Capacity in Patients Who Have Undergone Liver Transplantation.
Liver transplantation is a life-saving treatment of choice for patients with acute or chronic liver failure. Liver transplantation is performed with a graft taken from a living donor or cadaver in patients with end-stage liver…
- Trial name
- NCT05909371
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
End Stage Renal Disease, Hepatitis C
Renal Transplants in Hepatitis C Negative Recipients With Nucleic Acid Positive Donors
In this study, individuals without hepatitis C infection who are on the kidney transplant waitlist will receive a kidney from a deceased donor with hepatitis C infection and will be treated for hepatitis C at the same time.
- Trial name
- NCT03627299
- Testing
- 300mg glecaprevir/pibrentasivir 120mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Liver Transplant; Complications, Immunosuppression
Blood-Bile Ratio Tacrolimus After Liver Transplantation
Tacrolimus is the most widely used immunosuppressive drug in the prevention of rejection after solid organ transplantation. Pharmacokinetic studies in healthy volunteers and in transplanted patients have shown that this molecule…
- Conditions
- Liver Transplant; Complications, Immunosuppression, Transplant Failure, Transplant; Complication, Rejection
- Trial name
- BBRT (NCT03882164)
- Testing
- Blood-Bile Ratio of Tacrolimus
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Transplantation
Safety Study of Multipotent Progenitor Cells for Immunomodulation Therapy After Liver Transplantation
MultiStem ® is a new biological product, manufactured from human stem cells obtained from adult bone marrow. Factors expressed by MultiStem cells are believed to regulate immune system function and augment tissue repair.
- Trial name
- NCT01841632
- Testing
- MultiStem
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Prof. Dr. Marc-H. Dahlke, Ph. D.
Liver Transplantation, Postreperfusion Syndrome
Comparison of PRS According to Inhalation Agent During LDLT
The investigators tried to evaluate the effect of desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation surgery. The investigators used sevoflurane as a comparison.
- Trial name
- NCT01886664
- Testing
- sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Liver Transplant
Efficacy and Safety of Cyclosporine Microemulsion Given Once a Day in Adult Stable Liver Transplant Recipients
The purpose of this study is to determine whether cyclosporine microemulsion given once a day instead of twice a day benefits kidney function, blood pressure, lipid profile and glucose control in stable liver transplant…
- Trial name
- NCT00171509
- Testing
- Cyclosporine microemulsion
- Volunteers
- 61 people
- Sponsor
- Novartis
End-stage Liver Disease
Conditioning With Volatile Anesthetics in Liver Transplantation
The gap between the number of candidates for orthotopic liver transplantation and the availability of suitable liver grafts has led to a rise in deaths on most waiting lists.
- Trial name
- NCT00913276
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- University of Zurich
Intraoperative Hypotension
Hypotension Prediction Index in Patients Undergoing Liver Transplantation
A prospective, open-label and single-center study to determine whether the use of Acumen Hypotension Prediction Index software predicts the occurrence of hypotension.
- Trial name
- NCT04872504
- Testing
- Acumen HPI-enabled EV1000 screen
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Liver Transplant Recipients
Liver Transplant Recipients and 30-Second Lie-to-Sit Test
The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper…
- Trial name
- NCT07365098
- Testing
- 30-second lie-to-sit test, Modified Borg Scale, waist circumference
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Inonu University
Liver Transplantation
A Study of CellCept (Mycophenolate Mofetil) Combined With Calcineurin Inhibitors in Liver Transplant Patients.
This 2 arm study will compare the efficacy and safety of switching to CellCept combined with different regimens of reduced calcineurin inhibitors (CNI) in patients with liver transplants.
- Trial name
- NCT00717314
- Testing
- Mycophenolate mofetil, CNI (50%), CNI (≥75%)
- Where
- 11 sites in China
- Volunteers
- 87 people
- Sponsor
- Hoffmann-La Roche
Hepatic Transplantation
Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)
The choice of an immunosuppressant after hepatic transplant is now more difficult than before because of the increasing number of drugs available.
- Trial name
- NCT01388387
- Testing
- Tacrolimus pharmacokinetics
- Where
- France
- Volunteers
- 154 people
- Sponsor
- Rennes University Hospital
Evidence of Liver Transplantation, Effects of Immunosuppressant Therapy
Determining Equivalence Dose for Oral Versus Sublingual Administration of Tacrolimus in Hepatic Receptors
After liver transplantation one of the most important cost, for both patients and their health insurance system, is immunosuppressive drug therapy.
- Trial name
- FKosl (NCT02608606)
- Testing
- Tacrolimus
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Anastomotic Biliary Stricture Post Orthotopic Liver Transplant
WallFlex Biliary Post Liver Transplant IDE Pilot
The primary objective of this study is to demonstrate effectiveness of the WallFlex Biliary RX Fully Covered Stent for anastomotic biliary strictures in post-orthotopic liver transplant (OLT) patients.
- Trial name
- NCT01151280
- Testing
- WallFlex Biliary Fully Covered Stent
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
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