Clinical trials: Local; Infection
Local or Systemic Signs for Infection, Preterm Birth
Vaginal, Oral and Systemic Inflammation in Preterm Birth
The prevalence of preterm birth is not decreasing in the last decades despite of improving health care. Intrauterine infections are important in the etiology of preterm birth but the interconnection of systemic inflammation and…
- Trial name
- NCT01142752
- Where
- Switzerland
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Periodontal Attachment Loss
Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses
The purpose of this study is to test the hypothesis that dietary n-3 PUFA will have a beneficial effect on systemic and local markers of inflammation when combined with traditional, non-surgical periodontal therapy.
- Trial name
- NCT00632957
- Testing
- Omega-3 Fatty acid (with SRP or OHI)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Pertussis, Diphtheria
Immunogenicity and Safety of Tetraxim Versus Local DTP + IPV
The present clinical study will assess the immunogenicity and reactogenicity of Sanofi Pasteur's DTaP-IPV combined vaccines as a three-dose primary vaccination at 2, 4 and 6 months of age compared to commercially available…
- Conditions
- Pertussis, Diphtheria, Poliomyelitis, Tetanus
- Trial name
- NCT00319852
- Testing
- DTaP-IPV combined vaccine, DTaP vaccine
- Where
- South Korea
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Sanofi
Sepsis
Establishment of Early Diagnosis and Monitoring Model for Sepsis Patients
In recent years, although the clinical treatment of sepsis has been greatly improved, it is still an important cause of death in ICU patients, and seriously threatens human health.
- Trial name
- EDAMMFS (NCT04974411)
- Testing
- infection, sepsis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Catheter Infection
Local Inflammation Does Not Correlate With Bacterial Colonization and Contamination of Perineural Catheters
The aim of this study was to investigate the influence of alcoholic skin disin-fection before PNC (perineural catheter)-removal on the detection of bacteria on the subcutaneous part of the PNC or on the tip.
- Trial name
- NCT02599181
- Testing
- propanol-biphenol: Kodan
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Mumps, Rubella
Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines
This study will collect data on the safety of the MMRV vaccine (Priorix-Tetra™) used in routine practice in children aged 12 months to 12 years living in the Philippines.
- Conditions
- Mumps, Rubella, Measles, Varicella
- Trial name
- NCT01738841
- Testing
- Priorix-Tetra™, Safety data collection
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19 Pneumonia, Post-acute COVID-19 Syndrome
Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19
Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.
- Conditions
- COVID-19 Pneumonia, Post-acute COVID-19 Syndrome, Electric Impedance
- Trial name
- NCT05238623
- Testing
- additional EIT Measurement
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jan-Christoph Lewejohann
Haemophilus Influenzae Type b (Hib) Infection
Study in Infants (6-12 Months) Comparing Two Doses of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Vaccine Versus a Tetanus Toxoid-Conjugated Vaccine Available for the Prevention of Haemophilus Influenzae Type b Infections in China
This study will evaluate the safety and efficacy of two doses of two commercially available vaccines used to prevent Haemophilus influenzae type b infections in children 6-12 months of age.
- Trial name
- NCT01044316
- Testing
- Haemophilus influenzae type b (Hib) vaccine
- Where
- China
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Infections, Streptococcal
Post-marketing Surveillance Study With GSK Biologicals' Pneumococcal Vaccine in Healthy Infants in Philippines
The purpose of this post-marketing surveillance study is to evaluate the safety of Synflorix™ when administered according to the local Prescribing Information to healthy Filipino infants.
- Trial name
- NCT01046097
- Testing
- Synflorix™
- Where
- 2 sites in Philippines
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19
Message From Local Pharmacy Team
This experiment is part of a megastudy with a total of ten experimental conditions and a holdout control condition to which patients will be randomly assigned.
- Trial name
- NCT05613764
- Testing
- COVID Booster text messages
- Where
- United States
- Volunteers
- 520,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Staphylococcal Infection
Study of the Safety and Local Tolerability of Intranasal Gel Formulations of XF-73
This is a Phase I, multi-center, clinical study of XF-73 to evaluate the local (nasal) safety and tolerability of a modified, thinner lower viscosity formulation of intranasal XF-73 in healthy male and female subjects.
- Trial name
- NCT01592214
- Testing
- XF-73 in 2% Klucel gel, XF-73 in 4% Klucel gel
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Lipopolysaccharides
Effect of Intrapulmonary Recombinant Human Activated Protein C (APC) on Coagulation and Inflammation After Lipopolysaccharide (LPS)
Recombinant human Activated Protein C (rhAPC) has been shown to reduce the mortality of patients with severe sepsis. The biological effects of APC are pleiotropic, and can be roughly divided in anticoagulant and cytoprotective…
- Trial name
- NCT00943267
- Testing
- Drotrecogin alpha, Saline (NaCl 0.9%), Endotoxin
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Helicobacter Pylori Infection, Helicobacter Pylori Gastritis
Helicobacter Pylori Local Prevalence and Antibiotic Resistance
The clinical management of H. pylori infection depends essentially on two factors, prevalence and local resistance. In Germany, only limited data from rather small cohorts currently exist regarding both factors.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Gastritis, Drug Resistant Bacterial Infection, Antibiotic Resistant Infection
- Trial name
- HelicoPTER (NCT05561504)
- Where
- Germany
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Bacterial Vaginosis
Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity
To assess potential benefits associated with both intermittent (use for 3 weeks, remove for 1 week, as defined in the package insert) and continuous (use for 4 weeks, then replace) CVR use among women either with BV or at high…
- Trial name
- NCT02432404
- Testing
- NuvaRing
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, HSV-2 Genital Herpes
Retention and Duration of Activity of SPL7013 (VivaGel®) After Vaginal Dosing.
To assess the retention and anti-viral activity (human immunodeficiency virus (HIV) and herpes simplex virus 2 (genital herpes, HSV-2) of SPL7013 in cervicovaginal samples taken up to 24 hours after administration of 3% SPL7013…
- Trial name
- NCT00740584
- Testing
- 3% SPL7013 Gel (VivaGel)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Starpharma Pty Ltd
Helminthiasis
Assessment of Drug Efficacy of Local Albendazole
Infections with soil-transmitted helminthes (STH) occur throughout the developing world and remain a major public health problem in the poorest communities.
- Trial name
- NCT02420574
- Testing
- albendazole BENDEX, albendazole OVIS
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- University Ghent