Clinical trials: Local Anaesthetic Systemic Toxicity
Regional Anesthesia, Regional Anesthesia Block
Neurological Events and Unforeseen Risks After Locoregional-anesthesia
This is a multicenter, prospective, observational study aimed at determining the incidence of neurological and non-neurological complications following locoregional anesthesia procedures.
- Trial name
- NEURAL (NCT07238933)
- Testing
- Observational assessment after regional anesthesia
- Where
- 4 sites in Italy
- Volunteers
- 3,396 people
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Toxicity, Adverse Effects
Local Anaesthetics Toxicity and Intralipid®
The systemic toxicity of local anaesthetics may be treated using lipid emulsions ("lipid rescue"). However, there is no evidence-based proof of the efficacy of the treatment.
- Trial name
- TOXALIP (NCT01602250)
- Testing
- Intralipid®
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain, Acute Pain
Two Bupivacaine Concentrations for Rectus Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy
Pain after laparoscopic cholecystectomy remains clinically relevant, and current recommendations favour multimodal, opioid-sparing analgesia including regional techniques.
- Conditions
- Postoperative Pain, Acute Pain, Cholelithiasis, Anesthesia
- Trial name
- NCT07841951
- Testing
- Bupivacaine 0.25% - rectus intercostal fascial plane block, Bupivacaine 0.125% - rectus intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Postoperative Pain, Gynecologic Disease
Analgesic Effect of IntraPeritoneal LIGNOcaine in Gynaecological Open Surgery
The incidence of postoperative pain is highly prevalent among surgical patients. Inadequate postoperative pain control can slow the recovery and it increases the risk of postoperative complications, namely lung collapse and…
- Conditions
- Postoperative Pain, Gynecologic Disease, Local Anesthetic Systemic Toxicity
- Trial name
- NCT05897385
- Testing
- Lignocaine, Normal Saline
- Where
- Malaysia
- Volunteers
- 112 people
- Sponsor
- University of Malaya
Local Anesthetic Systemic Toxicity, Anesthesia, Local
Ropivacaine Plasma Concentration With or Without Epinephrine for Posterior Quadratus Lumborum Block
Introduction The posterior Quadratus Lumborum Block (pQLB) has been used in postoperative pain management after Cesarean Section (CS).
- Trial name
- NCT04562103
- Testing
- Epinephrine / Ropivacaine, Ropivacaine
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intravenous Lidocaine, Laparoscopic Surgery
Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery
This randomized controlled trial evaluates whether perioperative intravenous lidocaine infusion, combined with port-site ropivacaine infiltration, improves postoperative recovery after laparoscopic abdominal surgery.
- Conditions
- Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery, Local Anaesthetic Systemic Toxicity
- Trial name
- LivQor (NCT07414706)
- Testing
- Procedure/Standard care, ropivacaine, Lidocaine (intravenous infusion, perioperative)
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Education, Questionnaires
Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents
This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical…
- Trial name
- LAST (NCT07463274)
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Local Anesthetic Systemic Toxicity
Availability of Lipid Emulsion to Regional Anesthesia Programs at US Academic Anesthesia Departments
Significant data exists to suggest that lipid emulsion administration in the setting of local anesthetic toxicity has the potential to be life-saving.
- Trial name
- NCT01880034
- Testing
- Lipid Emulsion Survey
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Wisconsin, Madison
Local Anesthetic Systemic Toxicity, Pain
Ropivacaine Pharmacokinetics in ESP Blocks
This is a pharmacokinetic study to determine risk of local anesthetic systemic toxicity of ropivacaine when used in erector spinae plane blocks for thoracic surgery.
- Conditions
- Local Anesthetic Systemic Toxicity, Pain, Quality of Recovery
- Trial name
- NCT04807504
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block
Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery
This prospective single-center observational pharmacokinetic study will evaluate plasma levobupivacaine concentrations after ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing elective…
- Conditions
- Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block, Pharmacokinetic Analysis, Levobupivacaine
- Trial name
- LEVO-TAP-PK (NCT07581275)
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block with Levobupivacaine
- Volunteers
- 26 people
- Sponsor
- University of Liege
Postoperative Pain, Peripheral Neuropathy
Duration of Blockade of Peripheral Nerves With Bupivacaine Depending of the Adjuvants
The main aim of the investigator's study is to propose combination of local anesthetics and adjuvants that provides both adequate anesthesia during surgery and prolonged post-operative analgesia.
- Conditions
- Postoperative Pain, Peripheral Neuropathy, Fractures of the Upper Limb, Fracture of the Lower Limb (Except Hip), Initial Encounter
- Trial name
- DBBA (NCT04498923)
- Testing
- Bupivacaine, dexamethasone, epinephrine
- Where
- Ukraine
- Volunteers
- 68 people
- Sponsor
- Lviv National Medical University