Clinical trials: Local Anesthetic Effectiveness
Postoperative Pain, Cataract
Midazolam Additive to Local Anesthetic in Peribulbar Block
Regional eye blocks are usually preferred for ophthalmic procedures. Peribulbar block (PBB) is a safe alternative for patients undergoing cataract surgery.
- Conditions
- Postoperative Pain, Cataract, Local Anaesthetic Complication, Midazolam
- Trial name
- NCT03397069
- Testing
- Peribulbar block (control), Peribulbar block(M1), Peribulbar block(M2)
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al Jedaani Hospital
Dental Anxiety, Fear
Acupressure and Hand Massage for Reducing Anxiety During Dental Local Anesthetic Injections in Children
This study aims to compare the effects of acupressure ,hand massage , and routine behavioral management on anxiety in children undergoing dental local anesthetic injections .
- Trial name
- NCT07779837
- Testing
- acupressure, hand massage
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Molar Incisor Hypomineralization, Anesthesia, Local
Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars
The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia…
- Trial name
- NCT05964387
- Testing
- SDF
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Gallstones, Pain
Comparison of the Efficacy of Different Analgesic Strategies for Pain Control After Laparoscopic Cholecystectomy (LC)
The investigators collected 200 patients underwent safe uncomplicated laparoscopic cholecystectomy, then different strategies of pain control are used.
- Trial name
- Randomized (NCT07897435)
- Testing
- Low pneumoperitoneum, Local anaesthetic instillation to gallbladder bed
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Local Anaesthetic Drug Adverse Reaction
Computer - Controlled Intraligamentary Local Anaesthesia In Extraction of Primary Molars
Background: Exodontia poses a psychological threat for children, increasing the need for profound local anesthesia to assure painless extraction and maintain child cooperation on the dental chair.
- Trial name
- NCT04739735
- Testing
- Dental Local Anaesthesia
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Post Operative Pain
Analgesic Efficacy of Genicular Nerve Block Versus (IPack Block ) in Patients Undergoing (ACL) Repair
One of the most common injuries to the knee is an anterior cruciate ligament (ACL) sprain or tear due to trauma ACL damage is crippling and often requires repair with an arthroscopic method, which is an outpatient surgery.
- Trial name
- NCT06404658
- Testing
- Genicular nerve block
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to a lower molar, is more effective than a local anesthetic injection…
- Trial name
- NCT01862614
- Testing
- Articaine Hydrochloride + Epinephrine, Buffered Articaine Hydrochloride + Epinephrine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Local Anesthesia
Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar Nerve Block
The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for anterior and middle superior alveolar nerve (AMSA)…
- Trial name
- NCT02440347
- Testing
- Computer controlled anesthetic delivery by Anaeject, Conventional anesthetic delivery by carpule syringe
- Where
- Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Local Anesthesia
Efficacy and Safety of Lambdalina (Lidocaine Cream) Versus Placebo as an Anesthetic for Laser Hair Removal
Double-blind, randomized, placebo-controlled trial to assess the efficacy of Lambdalina (lidocaine cream) in reducing pain associated with laser hair removal in women.
- Trial name
- NCT01360749
- Testing
- Lambdalina® (Lidocaine 4% cream)
- Where
- 2 sites in Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- ISDIN
Anesthesia, Local
Effective Use of Pecs and Transversus Thoracics Plane Blocks for Subcutaneous Cardiac Pacemaker Insertion: A Case Series
Participants that undergo permanent cardiac pacemaker implantation can often present with challenging anesthetic management plans for the anesthesia provider.
- Trial name
- NCT03899701
- Testing
- PEC I and PEC II blocks
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia
Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia
The purpose of this study is to evaluate the effect of pH adjustment of the solution of articaine 4% with epinephrine 1:100.00, on the efficacy of anesthesia with the usage of a local anesthesia device that is needle-free…
- Trial name
- NCT07318311
- Testing
- Local anesthesia with articaine 4% with 1:100.000 epinephrine by using Comfort-in device, Local anesthesia with articaine 4% with 1:100.000 epinephrine with the addition of sodium bicarbonate 8,4% by using Comfort-in device
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Anxiety
Effectiveness of Mobile Applications During the Administration of Local Anesthesia in Pediatric Dentistry
To evaluate the mobile games' effect on patient acceptance of local anesthesia and decreasing dental pain and anxiety levels in pediatric patients.
- Trial name
- NCT04731181
- Testing
- mobile application (little lovely dentist).
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Irreversible Pulpitis, Pain
Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits
The aim of this study was to verify the effectiveness of an anesthetic called articaine for dental treatment, comparing it with an anesthetic commonly used in dental clinic: lidocaine.
- Trial name
- NCT01912755
- Testing
- 4% articaine with 1:100,000 epinephrine, 2% lidocaine with 1:100,000 epinephrine
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Anesthesia
Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
The purpose of the study is to compare two modalities of local anesthetic administration prior to the placement of cosmetic facial injectable fillers.
- Trial name
- NCT02379221
- Testing
- Injectable, Topical
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Safety Issues, Post Operative Pain
Safety and Efficacy of Wide Awake Local Anesthesia no Tourniquet Technique (WALANT) in Ankle Removal of Implant Surgery
Safety and efficacy of wide awake local anesthesia no torniquet technique (WALANT) in ankle surgery. Studying risks and benefits from WALANT compared to general anesthesia .
- Conditions
- Safety Issues, Post Operative Pain, Local Anesthetic Complication
- Trial name
- NCT05864664
- Testing
- Wide awake local anaesthesia no tourniquet technique
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ali Lari
Pain, Postoperative, Quality of Life
Efficacy of Two Local Anesthetics on Quality of Life After Endodontic Treatment
In this randomized controlled double-blinded study, subjects will be assigned to one of two study groups to either be anesthetized with Bupivacaine or Lidocaine prior to needed treatment of pulpectomy/endodontic debridement on a…
- Trial name
- B-OHIP14 (NCT04787731)
- Testing
- Bupivacaine Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Education, Questionnaires
Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents
This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical…
- Trial name
- LAST (NCT07463274)
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Gall Stones
Intraperitoneal Techniques of Local Anaesthesia During Laparoscopic Cholecystectomy
Pain following laparoscopic cholecystectomy (LC) results in morbidity and is a barrier to same day discharge. In several trials local anaesthetic (LA) washed over the liver and gall bladder decreases pain.
- Trial name
- NCT01090882
- Testing
- Bupivocaine, 0.9% normal saline solution
- Where
- United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Carpal Tunnel Syndrome, Anesthesia, Local
Ultrasound-guided Peripheral Nerve Block Versus Forearm Bier's Block in Patients Undergoing Carpal Tunnel Release
By means of an observer-blinded, randomized controlled trial, the analgesic efficacy of the forearm intravenous regional anesthesia and the ultrasound guided peripheral nerve block will be investigated in patients undergoing…
- Trial name
- NCT03411551
- Testing
- regional anesthesia
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Local Anesthetic Efficacy
Effectiveness of Nitrous Oxide 50% for Reducing Pain and Distress Associated with Needle-stick in Children
Venipuncture (puncturing of a vein) through the skin in order to insert a vein catheter (also know as cannula) is one of the most common needle-related medical procedures performed in children.
- Trial name
- NCT03342079
- Testing
- Local Anesthetics,(lidocaine 70 mg/tetracaine 70 mg topical patch; Synera)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital