Clinical trials: Local Anesthetic Effectiveness, open to volunteers
Irreversible Pulpitis, Anesthesia, Local
Cost-Effectiveness of Upfront Supplemental Anaesthesia in Symptomatic Irreversible Pulpitis
The goal of this clinical trial is to learn whether giving extra (supplemental) local anaesthetic injections at the start of treatment, rather than only after the standard injection fails, makes numbing of painful lower molar…
- Trial name
- UPFRONT-SIP (NCT07907120)
- Testing
- Inferior Alveolar Nerve Block With 2% Lidocaine With 1:80,000 Adrenaline, Upfront Buccal Infiltration With 4% Articaine With 1:100,000 Adrenaline, Upfront Intraligamentary Injection With 2% Lidocaine With 1:80,000 Adrenaline
- Where
- India
- Volunteers
- 234 people
- Sponsor
- Jamia Millia Islamia
Total Knee Anthroplasty
Ultrasound Guided Combined Adductor Canal, Superior Genicular Nerves and Anterior Femoral Cutaneous Nerves Blocks in Comparison With Periarticular Local Anesthesia Infiltration in Primary Total Knee Arthroplasty
Background: Pain management in total knee arthroplasty continues to evolve especially as an early postoperative analgesia is of paramount importance in achieving patient satisfaction and improving clinical outcomes.
- Trial name
- NCT07705230
- Testing
- Periarticular Infiltration, Ultrasound-Guided Triple Block Technique
- Where
- Saudi Arabia
- Volunteers
- 112 people
- Sponsor
- SAMEH ELSHERBINI
Molar Incisor Hypomineralization, Anesthesia, Local
Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars
The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia…
- Trial name
- NCT05964387
- Testing
- SDF
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hypnosis, Local Anaesthesia
Evaluation of the Effectiveness of Hypnosis Support on Patient Perception of Outpatient Surgery Under Local Anaesthesia
Many clinical trials assessing the effectiveness of hypnosis have been conducted in recent years, some of which show that hypnosis reduces pain perception better than drug treatments administered to control groups, and that it is…
- Conditions
- Hypnosis, Local Anaesthesia, Outpatient Surgery, FACE
- Trial name
- HYPNOFACE (NCT03926403)
- Testing
- State-Trait Anxiety Inventory ("Spielberger Self-Assessment Questionnaire"), hypnosis techniques, local anaesthesia
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Knee Osteoarthritis
Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis
This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT07381621
- Testing
- Perineural 5% Dextrose Injection, Perineural Local Anesthetic Injection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara Training and Research Hospital
Local Infiltration
Hyaluronidase Enzymes and Local Anesthesia
For both groups, local anaesthesia will be administered by one single surgeon and the extraction will be performed by another single surgeon across all subjects.
- Trial name
- NCT06980363
- Testing
- traditional inferior alveolar nerve block by articaine, hyaluronidase plus articain buccal infilteration
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Education, Questionnaires
Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents
This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical…
- Trial name
- LAST (NCT07463274)
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Dental Phobia, Dental Anxiety
"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction
This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe.
- Conditions
- Dental Phobia, Dental Anxiety, Dental Anesthesia, Dental Anesthesia Efficacy
- Trial name
- CCLAD-Pain (NCT07056101)
- Testing
- A conventional dental syringe, GENI High-Speed Injection, GENI Moderate-Speed Injection
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Tarek MHD kher al saka amini
Tooth Extraction, Local Anesthesia
Effect of AV Distraction and Acuapoint Stimulation in Pediatric Extraction on Pain and Anxiety
The aim of this study is to evaluate the effectiveness of audiovisual distraction and acuapoint stimulation on anxiety and pain perception during tooth extraction in children.
- Conditions
- Tooth Extraction, Local Anesthesia, Anxiety, Pain
- Trial name
- AV Acupoint (NCT07371442)
- Testing
- Acualief, Audiovisual, TELL SHOW DO
- Where
- Egypt
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Patients Undergoing Arthroscopic Knee Surgery
Evaluation of the Effectiveness of iPACK and Adductor Canal Blocks on Patients Undergoing Arthroscopic Knee Surgery
Arthroscopic knee surgery is one of the most commonly performed procedures in orthopedic surgery. More than 50% of patients experience moderate to severe pain after the operation.
- Trial name
- NCT07002580
- Testing
- IPACK and adductor canal block with Bupivacaine 0.25%, Spinal Anesthesia with Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sakarya University
Paroxysmal Atrial Fibrillation
Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation
This prospective, multicenter, randomized, controlled, noninferiority trial will compare local anesthesia with conscious sedation and general anesthesia in patients undergoing pulsed field ablation for paroxysmal atrial…
- Trial name
- PULSE-SED (NCT07877519)
- Testing
- Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System
- Where
- China
- Volunteers
- 390 people
- Sponsor
- China National Center for Cardiovascular Diseases
Anesthesia, Local Anesthesia
Can Caudal Dexmedetomidine Provide Effective Analgesia?
The goal of this clinical trial is to evaluate if caudal dexmedetomidine can provide effective analgesia during inguinoscrotal surgeries in pediatrics, if used caudally alone (and not as an adjunct to caudal bupivacaine).
- Trial name
- NCT05902780
- Testing
- Caudal Bupivacaine injection, Caudal Dexmedetomidine Injection
- Volunteers
- 50 people
- Sponsor
- Benha University
Overactive Bladder
Evaluation of Efficacy and Patient Satisfaction of Local Anaesthesia Versus Sedoanalgesia for Botox (R) Injection in the Urinary Bladder for the Treatment of Idiopathic Overactive Bladder
Patients with symptoms of overactive bladder suffer from frequent micturition, urinary incontinence and recurrent urinary tract infections.
- Trial name
- LA vs SA (NCT06437899)
- Testing
- intravesical botulinum toxin A injection unter local anaesthesia
- Where
- Austria
- Volunteers
- 84 people
- Sponsor
- Hospital LKH Hochsteiermark - Leoben
Pulpitis
Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With Pulpitis
The objective of this clinical trial is to evaluate whether buffered local anesthesia is more effective than conventional local anesthesia in reducing pain responses in school-aged children requiring dental treatment for…
- Trial name
- NCT07638254
- Testing
- Buffered Lidocaine with Epinephrine, idocaine with Epinephrine (Conventional)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Chronic Idiopathic Anopérineal Pain
EFFICACY of USUAL MANAGEMENT of CHRONIC IDIOPATHIC ANO-PERINEAL PAIN by USING LOCAL ANESTHETIC INFILTRATION
The goal of this clinical trial is to evaluate the efficacy of a posterior perineal block performed under neurostimulation at 1 month after local anesthetic infiltration in the treatment of chronic idiopathic ano-perineal pain.
- Trial name
- EPHI-DACI (NCT06602349)
- Testing
- Lidocaine 10 MG/ML, Saline
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Dental Anxiety, Pain Management
Electronic vs. Conventional Syringes: Impact on Pediatric Pain and Anxiety
Study Overview Purpose: To compare pain and anxiety levels in children aged 6-8 during local anesthesia administration using electronic vs. conventional syringes.
- Trial name
- NCT07045116
- Testing
- Electronic anesthesia, Conventional anesthesia
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Randa Omer Ahmed Bashir
MIH, Molar-Incisor Hypomineralization
Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental enamel defect of unclear etiology that affects permanent first molars and often permanent incisors, leading to increased porosity, hypersensitivity, and poor prognosis.
- Conditions
- MIH, Molar-Incisor Hypomineralization, Caries Assessment
- Trial name
- NCT07326241
- Testing
- Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Amputation
Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT
This multi-site clinical trial aims to assess the efficacy and safety of combining peripheral nerve stimulation with local anesthetic nerve blockade compared to the standard of care, i.e., local anesthetic blockade only using…
- Trial name
- NCT06964347
- Testing
- Ropivacaine 0.2% + nerve stimulator set, Ropivacaine 0.2%
- Where
- 4 sites in United States, Canada
- Volunteers
- 62 people
- Sponsor
- Stanford University
Dental Anesthesia, Sweet Taste Perception
Efficacy of Pre-cooling and Sweet-tasting Solution on Pain Related to Local Anesthesia Injection in Children
The study aims to determine whether pre-cooling and sweet-tasting solutions, alone or combined with topical anesthesia, provide better pain control during dental local anesthesia in children.
- Conditions
- Dental Anesthesia, Sweet Taste Perception, Pain and Anxiety, Behavioral Management
- Trial name
- NCT07835191
- Testing
- Dental anesthesia
- Where
- Egypt
- Volunteers
- 224 people
- Sponsor
- British University In Egypt
Pudendal Neuralgia
Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.
Pudendal neuralgia (PN) is a chronic nerve compression syndrome causing neuropathic pain. Treatment includes medication, infiltration and decompressive surgery.
- Trial name
- EPHI-DACI (NCT06872437)
- Testing
- Lidocaine Injectable Solution, Saline Solution for Block
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon