Clinical trials: Local Disease
Knee Osteoarthritis, Low Level Laser Therapy
Low-Level Laser Therapy in Knee Osteoarthritis: Effects on Clinical Outcomes, Femoral Cartilage Thickness and Regional Sarcopenia
It was designed as a single-center, prospective, randomized controlled study. The study consists of two groups. Both groups of patients will receive a conventional home based exercise program.
- Conditions
- Knee Osteoarthritis, Low Level Laser Therapy, Regional Sarcopenia, Exercise Theraphy
- Trial name
- NCT07078877
- Testing
- home based exercise, Low Level Laser Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Ankara Etlik City Hospital
Childhood Langerhans Cell Histiocytosis, Fanconi Anemia
Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases
RATIONALE: Umbilical cord blood transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy.
- Conditions
- Childhood Langerhans Cell Histiocytosis, Fanconi Anemia, Leukemia, Lymphoma
- Trial name
- NCT00084695
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Milton S. Hershey Medical Center
Osteoporosis
GRACE II (General Retrospective Analysis of Commercial Experience With AGN1 LOEP)
The study is designed as a retrospective, multicenter study for subjects previously treated with the AGN1 LOEP Kit in the proximal femur as part of standard hospital practice. This will be a non-randomized and non-blinded study.
- Trial name
- NCT07594639
- Testing
- AGN1 LOEP
- Where
- Belgium
- Volunteers
- 305 people
- Sponsor
- AgNovos Healthcare, LLC
Alzheimer's Disease
A Study to Assess Regional Cerebral Blood Flow as an Alzheimer's Disease Biomarker Compared to Positron Emission Tomography in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects (Study MK-0000-068)(COMPLETED)
The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimer's disease.
- Trial name
- NCT00757939
- Testing
- MRI, FDG-PET
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block
Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery
This prospective single-center observational pharmacokinetic study will evaluate plasma levobupivacaine concentrations after ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing elective…
- Conditions
- Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block, Pharmacokinetic Analysis, Levobupivacaine
- Trial name
- LEVO-TAP-PK (NCT07581275)
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block with Levobupivacaine
- Volunteers
- 26 people
- Sponsor
- University of Liege
Asthma
Study to Evaluate Tezepelumab in Adults With Severe Uncontrolled Asthma
A Regional, Multicentre, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Severe Uncontrolled Asthma
- Trial name
- DIRECTION (NCT03927157)
- Testing
- Experimental: Tezepelumab
- Where
- 72 sites in China, Philippines and 1 more
- Volunteers
- 405 people
- Sponsor
- AstraZeneca
Ventilatory Defect, COVID-19
Visualizing Regional Lung Ventilation in Patients With Postacute-COVID-19
There is a lack of data of spontaneous breathing patients with post-COVID-19 syndrome (PCS) examined by Electrical impedance tomography (EIT). We compare 100 patients with PCS with 50 healthy probands.
- Conditions
- Ventilatory Defect, COVID-19, Post-acute COVID-19 Syndrome, Electric Impedance Tomography
- Trial name
- ViReVentPoCov (NCT05441657)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jan-Christoph Lewejohann
Pain, Satisfaction, Patient
The Effect of Local Cold Application and ShotBlocker Use in Subcutaneous Injection on Injection Pain and Patient Satisfaction
The research was conducted as a single-blind, randomized controlled, experimental study to determine the effect of ShotBlocker and local cold application on pain and patient satisfaction in subcutaneous heparin injection.
- Trial name
- NCT06563648
- Testing
- shotblocker, local cold application
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bornova No. 25 Mevlana Family Health Center
Bundle-Branch Block, Left, Cardiac Failure
Prognosis of Patients With Compete Left Bundle Branch Block
The investigators sought to evaluate the morphological and functional changes, risk stratification and prognosis of patients of participants with compete left bundle branch block (CLBBB).
- Conditions
- Bundle-Branch Block, Left, Cardiac Failure, ICD/Pacemaker Implantation, Cardiovascular Magnetic Resonance Imaging
- Trial name
- NCT03096678
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Anesthesia, Local
Analgesic Effect of Illiohypogastic & Ilioinguinal Nerve Block in TAVR - TF (Prospective Randomized Study)
The purpose of the study is to compare the effect of illiohypogastric and ilioinguinal nerve block with the local infiltration with lidocaine in patients undergoing TAVI
- Trial name
- NCT06362915
- Testing
- Lidocaine, Bupivacain
- Where
- 2 sites in Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Gastrointestinal Carcinoid Tumor, Islet Cell Tumor
Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Gastrointestinal Carcinoid Tumor, Islet Cell Tumor, Lung Cancer, Neoplastic Syndrome
- Trial name
- NCT00227617
- Testing
- bevacizumab, 5-fluorouracil, leucovorin
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Francisco
Post Operative Pain
Analgesia After Video-Assisted Thoracic Surgery
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
- Trial name
- NCT05094323
- Testing
- Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine, Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Inguinal Hernia
Ultrasound Guided Local Anesthetic Field Block (A Five Step Procedure) for Open Inguinal Hernia Repair
The aim of this study is to evaluate success, efficacy, feasibility and safety of a simple five step ultrasound guided local anesthetic infiltration technique for unilateral open inguinal hernia repair and to determine the…
- Trial name
- NCT03193723
- Testing
- US guided five step field block, Spinal anesthesia
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Eslam Ayman Mohamed Shawki
Prurigo Nodularis (PN)
Early and Long-Term Efficacy and Immune Changes With Dupilumab in Prurigo Nodularis
With the arrival of dupilumab as the first available targeted therapy for PN, there is an unmet need for real-world data and translational research on the working mechanism of dupilumab on PN, to optimize individualized targeted…
- Trial name
- NCT07276425
- Testing
- Dupilumab
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- UMC Utrecht
Anesthesia, Local, Pain Control
Should Maxillary Buccal Infiltration Anesthesia be Given in a Closed Mouth Technique?
To study the patients' and dentists' perception of receiving/ administering maxillary buccal infiltration anesthesia using an open or closed mouth techniques
- Trial name
- NCT03921190
- Testing
- Local anesthesia
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Hypotension, Surgery-Complications
The Effects of Nicardipine and Esmolol Applied for Controlled Hypotension
In this study, the effects of nicardipine and esmolol applied for controlled hypotension in rhinoplasty on hemodynamics and regional renal oxygenation will be investigated.
- Conditions
- Hypotension, Surgery-Complications, Oxygen Deficiency
- Trial name
- NCT05430724
- Testing
- Controlled hypotention
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yuzuncu Yil University
Regional Anesthesia, Anxiety
Uncontrolled Disinformation About Regional Anesthesia and Pregnant Patients.
Nowadays, hundreds of information about regional anesthesia are accessed from any internet search engine when a question is written about the methods of anesthesia that can be applied during C/S.
- Conditions
- Regional Anesthesia, Anxiety, Social Media Addiction, Spinal Anesthesia
- Trial name
- NCT05416541
- Testing
- social media
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Diabetes Mellitus, Type 2
A Research Study, Looking at How Tresiba® Works in People With Type 2 Diabetes in Local Clinical Practice in China
The purpose of the study is to collect information on how Tresiba® works in patients with type 2 diabetes in China. The study will be based on data already recorded in participants' medical records and no new tests or procedures…
- Trial name
- CN-TREAT (NCT04227431)
- Testing
- Insulin degludec
- Where
- 56 sites in China
- Volunteers
- 938 people
- Sponsor
- Novo Nordisk A/S
Cesarean Section
The Effect of Warm Local Anesthetic Solution on Epidural Anesthesia
The investigators are going to compare the onset and duration of nerve blockage with the use of pre-warmed (38°C) and room temperature (20°C) local anesthetic solutions (ropivacaine and fentanyl) on epidural anesthesia for…
- Trial name
- NCT03860402
- Testing
- Temperature
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Cataract, Vitreous Disorder
Comparison of Two Surgical Sequences "Cataract Surgery Then Vitrectomy" Versus "Vitrectomy Then Cataract Surgery" Under Local-regional Anesthesia
Cataracts and vitreo-retinal conditions are frequently associated and can lead to a combined surgery to treat both diseases at the same time.
- Trial name
- VICAR (NCT05583331)
- Testing
- Cataract surgery, Vitrectomy
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Elsan
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.