Clinical trials: Local Disease
Metastatic Melanoma
Local Modulation of Immune Receptors to Enhance the Response to Dendritic Cell Vaccination in Metastatic Melanoma
Our proposed study is designed to test the safety of a new vaccine against melanoma. The induction of immune activity against cancers such as melanoma is a promising approach to cancer treatment, but to date, only a few…
- Trial name
- NCT01216436
- Testing
- Vaccination with RNA-transfected mature autologous DC
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Vasodilation, Diabetes Mellitus, Type 2
Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics
Application of vibration has been previously shown to affect tissue perfusion and utilized in different branches of medicine. Little is known about the acute impact of vibration application on peripheral artery hemodynamics.
- Trial name
- VMD (NCT05492071)
- Testing
- Local Vibration Application Following Flow Mediated Dilation, Flow mediated dilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Knee Arthroscopy, Spinal Anesthesia
Comparison of Hyperbaric Prilocaine With Chloroprocaine for Intrathecal Anaesthesia in Day Case Knee Arthroscopy
This study compares intrathecal 1% plain chloroprocaine with intrathecal 2% hyperbaric prilocaine for patients undergoing ambulatory knee arthroscopy in terms of efficacy and side effects
- Trial name
- NCT03038958
- Testing
- Isobaric 2-chloroprocaine, Hyperbaric prilocaine
- Where
- 2 sites in Belgium
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Suspected Malignant Lung Neoplasm, Pleural Effusion
First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.
Non randomized study with two groups. The study group includes patients with suspected malignant pleural effusion, in whom the investigation of pleural effusion begins directly with pleural biopsy by Local Anesthesia Thoracoscopy…
- Conditions
- Suspected Malignant Lung Neoplasm, Pleural Effusion, Pleural Effusion, Malignant, Mesothelioma, Malignant
- Trial name
- FLAT (NCT06946498)
- Testing
- Local Anesthesia Thoracoscopy, Pleuroscopy with Rigid Thoracoscope and Forceps biopsies
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Local Anesthetic Effectiveness
Local Anesthetics New Formulations: From Development to Clinical Tests
This blinded cross-over study aim to evaluate the efficacy and the pharmacokinetics of a previously reported liposome-encapsulated mepivacaine formulations.
- Trial name
- NCT01032798
- Testing
- mepivacaine
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Bladder Carcinoma, Post-operative Pain
Continuous Infusion of Ropivacaine Hydrochloride in Reducing Pain After Surgery in Patients With Bladder Cancer
This randomized phase IV trial studies how well the continuous infusion of ropivacaine hydrochloride works in reducing pain after surgery in patients with bladder cancer.
- Trial name
- NCT02438852
- Testing
- Questionnaire Administration, Ropivacaine Hydrochloride
- Where
- United States
- Sponsor
- University of Southern California
Breast Cancer, Post Operative Pain
Dexmedetomidine Versus Dexamethasone as Adjuncts in Erector Spinae Plane Block in Modified Radical Mastectomy
The aim of this study is to evaluate the analgesic efficacy and safety of adding dexmedetomidine versus dexamethasone to levobupivacaine in ultrasound guided ESPB for patients undergoing modified radical mastectomy
- Trial name
- NCT05447949
- Testing
- Adjuncts to levobupivacaine in Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Gastrointestinal Microbiome, Immunoglobulin A
The Effect of Maternal Dadiah Supplementation During Pregnancy on Child Growth and Gastrointestinal Health Outcomes
The aim of our study is to assess the effect of giving dadiah as a supplement to pregnant women on improving the growth and digestive health of children.
- Conditions
- Gastrointestinal Microbiome, Immunoglobulin A, Growth; Stunting, Nutritional
- Trial name
- NCT05140928
- Testing
- Dadiah Pudding, Pudding without Dadiah
- Where
- Indonesia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Andalas University
Fungal Infection
Empiric Therapy of Patients With Persistent Fever and Agranulocytosis Using Caspofungin
The purpose of this study is evaluating the efficacy and safety of generics caspofungin in the treatment of the patients with neutropenic and fever.Another purpose of this study is comparing the pharmacokinetic characteristics of…
- Trial name
- NCT03857399
- Testing
- Caspofungin
- Where
- 6 sites in China
- Volunteers
- 32 people
- Sponsor
- Cttq
Prostate Cancer (Adenocarcinoma), Vitamin D on Tumor Response and Inflammatory Markers
Comparative Analysis of Immunological Responses to Vitamin D Replacement Therapy in Black and West African Men Diagnosed With Prostate Cancer: Elucidating Differential Effects on Immune Function Between Patients With Localized Disease and Those With Metastatic Progression
This study is testing whether fixing vitamin D deficiency in Black/West African men with prostate cancer can strengthen their immune system, improve quality of life, and even slow cancer progression compared to those who remain…
- Trial name
- iCCaRE (NCT07598032)
- Testing
- vitamin D 25(OH)D
- Where
- Nigeria
- Volunteers
- 200 people
- Sponsor
- University of Ilorin Teaching Hospital
Breast Cancer, Prostate Cancer
Effect of Radiotherapy Variables on Circulating Effectors of Immune Response and Local Microbiome
Exposure to radiation can impact immune cells that are present in the blood, such as lymphocytes. It is hypothesized that larger radiation fields and/or longer courses of radiation, result in greater decrease in immune cells.
- Trial name
- NCT03383107
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Weill Medical College of Cornell University
Behavior, Child, Dental Anxiety
Pain and Anxiety Reduction Using a Vibrating Eye Massage Device With Relaxing Nature Sounds
This study aims to evaluate the effectiveness and acceptance of an eye massage device that produces nature sounds and vibratory stimulations in the management of anxious pediatric patients during inferior alveolar nerve block…
- Conditions
- Behavior, Child, Dental Anxiety, Anesthesia, Local
- Trial name
- NCT05592587
- Testing
- Evaluation of the effectiveness of eye massage device producing both vibrations and nature sounds distraction in the management of anxious pediatric patients during inferior alveolar nerve., Evaluation of the effectiveness of eye massage device producing vibratory stimulations distraction in the management of anxious pediatric patients during inferior alveolar nerve., Evaluation of the effectiveness of basic behavior guidance techniques without using any type of distraction aids in the management of anxious pediatric patients during inferior alveolar nerve.
- Where
- Syria
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Damascus University
Pain, Cervical
Analysis of Injectate Spread During Erector Spinae Block
The primary purpose of this study was to identify the ESPB spread level in the craniocaudal direction when performed at the T2 level.
- Trial name
- NCT05280847
- Testing
- Erector spinae plane block
- Where
- 2 sites in South Korea
- Volunteers
- 159 people
- Sponsor
- Keimyung University Dongsan Medical Center
Long-Eye Surgeries
Remifentanil and Remimazolam to Limit Patient Movement
Local anesthetics (LA) may be administered by injection (retrobulbar, peribulbar, subconjunctival, lid, or facial block) or by instillation (topical anesthesia), Considerable drawbacks of local anesthesia in these patients…
- Trial name
- NCT06583811
- Testing
- Remifentanil
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Egymedicalpedia
Postoperative Pain, Inflammation
Assessment of the Operative Course in Connection With Removal of Lower Third Molars
The aim of this study is to compare postoperative complications after removal of lower third molars using two different types of anaesthetics and two different treatments against swelling and inflammation (methylprednisolone and…
- Trial name
- NCT00805298
- Testing
- methylprednisolone, xyloplyin adrenalin, marcain adrenalin
- Where
- Denmark
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Malaria
A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon
The purpose of the study is to evaluate and compare the efficacy of parenteral artesunate with three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital located in the South region of…
- Trial name
- NCT02563704
- Testing
- Artesunate, Quinine
- Volunteers
- 238 people
- Sponsor
- University of Yaounde 1
Healthy
Development of Early Diagnostic Techniques and Setup of Local Therapeutic Guidelines and Standards
End-stage renal disease (ESRD) is a healthy, social and economic threat worldwide. In the past ten years, the incidence and prevalence of ESRD patients have tremendously increased, ranking at the top in the world.
- Trial name
- Hmodialysis (NCT00912704)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Infertility, Male Factor
FemaSeed LOCAL Artificial Insemination Trial
Brief Summary: The objectives of the trial are to evaluate the safety and effectiveness of the FemaSeed Localized Directional Insemination for artificial insemination, now known as the FemaSeed Intratubal Insemination since FDA…
- Trial name
- LOCAL (NCT04968847)
- Testing
- FemaSeed Localized Directional Insemination
- Where
- 18 sites in United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Femasys Inc.
COPD
A Single-dose Study to Investigate the Effects of 3 Different Doses of Inhaled AZD2115 in COPD Patients
This study in COPD patients will investigate the bronchodilatory effect of AZD2115. AZD2115 will be tested versus placebo and active comparators.
- Trial name
- NCT01498081
- Testing
- AZD2115, Indacaterol, Indacaterol + Tiotropium
- Where
- 6 sites in Poland, Sweden
- Volunteers
- 39 people
- Sponsor
- AstraZeneca
Pulmonary Hypertension
11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension
This study is looking at differences in metabolism and functional imaging between pulmonary hypertension subjects with normal right ventricular function and persistent right ventricular dysfunction.
- Trial name
- NCT01917136
- Testing
- 11C-acetate, [18F]Fluoro-2-deoxy-2-D-glucose, Cardiac MRI
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Pennsylvania
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