Clinical trials: Loop Electrosurgical Excision
Uterine Cervical Dysplasia
LLETZ Under Direct Colposcopic Vision
To assess the benefits of large Loop excision of the transformation Zone (LLETZ) under direct colposcopic Vision.
- Trial name
- NCT02910388
- Testing
- LLETZ with colposcopy, LLETZ without colposcopy
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Cancer, CIN2
Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV
The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among…
- Conditions
- Cervical Cancer, CIN2, CIN3, Human Immunodeficiency Virus
- Trial name
- ACT 2 (NCT05413811)
- Testing
- 5 Fluorouracil (5 FU) Cream
- Where
- South Africa
- Volunteers
- 180 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Esketamine, Loop Electrosurgical Excision
Anesthesia for Loop Electrosurgical Excision Procedure (LEEP).
The goal of this prospective, randomized controlled study study is to investigate the efficacy and safety of propofol combined with different doses of esketamine (ESK) for anesthesia during loop electrosurgical excision procedure…
- Conditions
- Esketamine, Loop Electrosurgical Excision, Propofol
- Trial name
- ESK，LEEP (NCT06574945)
- Testing
- intravenous injection of propofol only, intravenous injection of propofol +esketamine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Qian Wu
Cervical Precancerous Lesions
Optimal Timing for Performing Loop Electrosurgical Excision Procedure
Cervical precancerous lesions (cervical intraepithelial neoplasia) are frequently diagnosed and treated in women of reproductive-aged [1].
- Trial name
- NCT03952975
- Testing
- Vaginal bleeding
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
HIV Infections, HPV Infection
Assessment of the Effectiveness of TA Versus LEEP for Cervical Cancer Risk Reduction in WLHIV in Mozambique
Given that WLWH are more likely to develop persistent HPV infection and CC, effective screening and the management and treatment of pre-cancerous cervical abnormalities is critical to decrease the global burden of cervical…
- Conditions
- HIV Infections, HPV Infection, CIN 2/3
- Trial name
- NCT06326294
- Testing
- Thermal ablation, LOOP ELECTROSURGICAL EXCISION PROCEDURE
- Where
- Mozambique
- Volunteers
- 4,844 people
- Sponsor
- Instituto Nacional de Saúde, Mozambique
Cervical Dysplasia
Large Loop Excision of the Transformation Zone (LLETZ) With vs Without IntraOperative Application of Lugol's Iodine
Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the gynecologist's preventive smear test and can thus…
- Trial name
- LLETZ-IOLI (NCT05132114)
- Testing
- Lugol's iodine test
- Where
- Germany
- Volunteers
- 230 people
- Sponsor
- Ruhr University of Bochum
Cervical Intraepithelial Neoplasia
Efficacy Study of Diathermy Cone Biopsy for the Treatment of Cervical Intraepithelial Lesion
The purpose of this trial is to determine whether SWETZ (Straight Wire Excision of Transformation Zone) is a superior alternative to LLETZ cone (Large Loop Excision of Transformation Zone cone biopsy) in the management of…
- Trial name
- NCT00995020
- Testing
- Straight Wire Excision of Transformation Zone, Large Loop Excision of Transformation Zone (cone biopsy)
- Where
- 2 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Oswaldo Cruz Foundation
Uterine Cervical Dysplasia
LLETZ With Videocolposcopy Versus LLETZ With Binocular Colposcopy
To assess the benefits of performing large Loop excision of the transformation Zone (LLETZ) using videocolposcopy compared to binocular colposcopy.
- Trial name
- NCT04326049
- Testing
- LLETZ with videocolposcope, LLETZ with binocular colposcope
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Efficacy of Tachosil® for Prevention of Hemorrhage After Loop Electrosurgical Excisional Procedure (LEEP)
This study is aimed at identifying the efficacy of Tachosil® for prevention of hemorrhage in patients with cervical intraepithelial neoplasia or cervical cancer after undergoing a loop electrosurgical excisional procedure (LEEP).
- Trial name
- TACO (NCT02629510)
- Testing
- Tachosil
- Where
- South Korea
- Volunteers
- 268 people
- Sponsor
- Asan Medical Center
Uterine Cervical Dysplasia
LLETZ Under General Versus Local Anesthesia
The investigators conduct a prospective, randomized trial to assess the benefits of performing large loop excision of the transformatione zone (LLETZ) under local anesthesia and compare it to LLETZ under general anesthesia.
- Trial name
- NCT03494686
- Testing
- LLETZ under local anaesthesia, LLETZ under general anaesthesia
- Where
- Germany
- Volunteers
- 229 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Intraepithelial Neoplasia
Recurrence in High-grade Lesions After Conization
Objectives: To identify factors associated with disease recurrence in patients with high-grade cervical intra-epithelial neoplasia (CIN) undergoing large loop excision of the transformation zone (LLETZ).
- Trial name
- NCT02540421
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Procedure, Gynecologic Surgical
Anesthesia on Postoperative Pain After Loop Electrosurgical Excision Procedure
The loop electrosurgical excision procedure (LEEP) is a modified cervical conization that is performed with an electrosurgical loop.
- Trial name
- NCT04984122
- Testing
- LEEP
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
High-grade Cervical Intraepithelial Neoplasia
An Alternative Treatment for Cervical Intraepithelial Neoplasia Using the Focal Loop Electrosurgical Excision Procedure
This is a pilot study to test the short-term effectiveness of an alternative treatment approach for precancerous cells of the cervix.
- Trial name
- NCT02220192
- Testing
- Focal LEEP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Cervical Cancer, HIV
Evaluation of a Novel Optical Microscope With a Deep Depth of Field (DeepDOF) to Provide Histologic-quality Images on Cervical Biopsies and Loop Electrosurgical Excision Procedure (LEEP) Specimens at the Point-of-care
All patients will be enrolled in Mozambique and Brazil. They will provide informed consent to use their cervical biopsy and/or LEEP specimens for imaging with DeepDOF prior to sending for standard of care processing and…
- Trial name
- NCT06850402
- Testing
- DeepDOF Images
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- M.D. Anderson Cancer Center
High-Grade Squamous Intraepithelial Lesions
Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSIL
This study aimed to analyze perioperative information in patients with high-grade squamous intraepithelial lesion (HSIL) undergoing total hysterectomy (TH), offering insights into optimal surgery timing, selecting the operation…
- Trial name
- NCT06325592
- Testing
- surgical timing and operation path
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Cervical Intraepithelial Neoplasia
A Trial of Two Electrosurgical Conizations: Histopathological Analysis of Excision Margins
The purpose of this trial is to evaluate if Straight Wire Excision of the Transformation Zone (SWETZ) is superior to (Large Loop Excision of the Transformation Zone) LLETZ cone in reducing the incomplete excision of disease.
- Trial name
- NCT01929993
- Testing
- SWETZ, LLETZ cone
- Where
- Brazil
- Volunteers
- 164 people
- Sponsor
- Oswaldo Cruz Foundation
Stenosis Cervix
How to Avoid Cervical Stenosis After LEEP in High Grade Cervical Dysplasia?
Cervical stenosis may occur in up to 19% after conization. It is a cause of infertility and amenorrhea. This study will test a new device named DUDA Device ("Dispositivo Uterino para dilatar canal endocervical") placed just after…
- Trial name
- DUDA (NCT02500966)
- Testing
- DUDA device, LEEP
- Where
- Brazil
- Volunteers
- 265 people
- Sponsor
- Barretos Cancer Hospital
Cervical Intraepithelial Neoplasias
Research on the Application of Patient Navigation-based Management Model of Patients After LEEP
Cervical cancer poses a significant threat to women's health and is a crucial public health issue. Early detection and treatment of cervical lesions and standardized management have emerged as essential pillars in the Global…
- Trial name
- NCT06695871
- Testing
- Patient navigation-based health management
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
Uterine Cervical Dysplasia
Fischer Cone Biopsy Excisor Versus Loop Excision Procedure for Conization
In a randomized clinical trial of 160 women undergoing conization for cervical dysplasia, two electrosurgical excision methods, Fischer Cone Biopsy Excison vs. Loop Excision Procedure, will be compared.
- Trial name
- NCT02515162
- Testing
- Fischer Cone Biopsy Excisor, Loop Excision Procedure
- Where
- Germany
- Volunteers
- 178 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Uterine Cervical Dysplasia
Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)
Women undergoing a LEEP procedure who receive lidocaine buffered with sodium bicarbonate for their cervical block will experience less injection pain than women who receive plain lidocaine.
- Trial name
- NCT01405768
- Testing
- sodium bicarbonate buffered lidocaine, Non-buffered lidocaine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine