Clinical trials: Lorazepam
Stress Disorders, Post-Traumatic
Computational Assessment of GABA Receptor Modulation in PTSD
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications.
- Trial name
- NCT06852469
- Testing
- Lorazepam 1 mg tablet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy
Phase 1 Study to Characterize the Safety and Pharmacokinetics of Single Intravenous Dose of Lorazepam in Healthy Japanese Adult Subjects
The purpose of this study is to evaluate safety, tolerability and pharmacokinetics of 2-mg lorazepam intravenous administration in healthy Japanese adult subjects.
- Trial name
- NCT01994668
- Testing
- Lorazepam
- Where
- Japan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Anxiety Disorders, Generalized Anxiety Disorder
Lorazepam-Induced Toxicity in the Aged
This study will compare the effects of an acute dose of lorazepam to a placebo in elderly patients with generalized anxiety disorder (GAD).
- Trial name
- NCT00044642
- Testing
- Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Claustrophobia
Premedication for Claustrophobic Patients for MRI Scan
Claustrophobia is an irrational fear of restriction and suffocation. It is a specific phobia, according to DSM 5. Claustrophobic patients may fear that restriction of their limbs will hinder their ability to move quickly towards…
- Trial name
- NCT05876117
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Pain, IUD
Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study
The objective of this pilot study is to discuss the feasibility of prescribing lorazepam prior to IUD insertion and of measuring effect of lorazepam on anxiety and pain with Intrauterine Device (IUD) insertion.
- Trial name
- NCT06496854
- Testing
- Lorazepam 1 mg, Ibuprofen 800 mg
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Lorazepam, Neuroimaging
Lorazepam Effects on Neuroimaging Measures
This within-subject, double blind, randomized controlled study will investigate the effects of a widely used benzodiazepine (BZD), lorazepam, on various neuroimaging measures.
- Trial name
- NCT04671836
- Testing
- Lorazepam 1Mg Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial studies lorazepam, diphenhydramine…
- Trial name
- NCT01204255
- Testing
- lorazepam, diphenhydramine hydrochloride, haloperidol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use
Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation
The primary objective of this study is to determine the noninferiority of inhaled loxapine compared to intramuscular haloperidol/lorazepam on agitation reduction at 120 minutes.
- Conditions
- Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use, Lorazepam Causing Adverse Effects in Therapeutic Use, Loxapine Causing Adverse Effects in Therapeutic Use
- Trial name
- loxapine (NCT03110900)
- Testing
- Haloperidol + lorazepam, Loxapine
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Healthy Subjects
Exploring the Effects of Diazepam and Lorazepam
Aims : exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using…
- Trial name
- ibid (NCT00696033)
- Testing
- Diazepam, Lorazepam
- Where
- 2 sites in France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Healthy
Fasting Study of Lorazepam Tablets 2 mg and Ativan Tablets 2 mg
The objective of this study was to investigate the bioequivalence of Mylan's lorazepam 2 mg tablets to Wyeth's Ativan 2 mg tablets following a single, oral 2 mg (1 x 2 mg) dose administered under fasting conditions.
- Trial name
- NCT00649818
- Testing
- Lorazepam Tablets 2 mg, Ativan Tablets 2 mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Alcohol Withdrawal
Oxytocin Treatment of Alcohol Withdrawal
Purpose: Test whether intranasal administration of the neuropeptide, oxytocin, is effective in decreasing alcohol withdrawal symptoms, the number of bouts of withdrawal requiring standard medication treatment (lorazepam) and the…
- Trial name
- NCT01212185
- Testing
- intranasal oxytocin spray, intranasal spray without oxytocin
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Benign Prostate Hypertrophy(BPH)
Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia
The primary aim of the study is to show that methoxyflurane-lorazepam-percocet combination administrated 'per os' is non inferior to deep intravenous sedation in achieving analgesia during Rezum convective radiofrequency water…
- Trial name
- NCT07017452
- Testing
- Methoxyflurane - Penthrox, Control, Percocet Pill
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Alcohol Withdrawal Syndrome(AWS)
Comparing the Treatment of Alcohol Withdrawal Syndrome Using Gabapentin Versus Lorazepam
The purpose of this study was to evaluate if the medication Gabapentin, which is not approved for the treatment of alcohol withdrawal, is effective in the treatment of alcohol withdrawal syndrome compared to treatment with…
- Trial name
- NCT00229125
- Testing
- Gabapentin, Lorazepam
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alzheimer's Disease
The Impact of Lorazepam on Cognition in APOE e4 Carriers
We expect the results of this pilot study to justify a larger study that follows people to determine if certain tests of memory and attention, performed while sleepiness is induced by a single dose of lorazepam (a widely used…
- Trial name
- NCT00586430
- Testing
- lorazepam
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Effect of Ketanserin, Olanzapine, and Lorazepam After LSD Administration on the Acute Response to LSD in Healthy Subjects
The main objective of this study is to determine whether administration of ketanserin (40 mg), olanzapine (10 mg), and lorazepam (2 mg) after administration of LSD (150 µg) attenuates and shortens the subjective LSD response (any…
- Trial name
- LBL (NCT05964647)
- Testing
- LSD (150 µg) + ketanserin (40 mg), LSD (150 µg) + olanzapine (10 mg), LSD (150 µg) + lorazepam (2 mg)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Volunteer
A Sedation/Cognition/EEG Study Using AZD6280 and Comparator
The purpose of the study is to determine the effects of AZD6280 compared to lorazepam on sleepiness, concentration and brain activity.
- Trial name
- NCT00750802
- Testing
- AZD6280, Lorazepam
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
ADASUVE-Lorazepam Drug-Drug Interaction
This study will compare the safety and effects over time for giving both ADASUVE and lorazepam (intramuscular) compared to that of each agent given alone.
- Trial name
- NCT01877642
- Testing
- Lorazepam 1 mg IM, Inhaled loxapine 10 mg
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Healthy Volunteers
Evaluation of the Effects of Etifoxine 100 mg and Lorazepam 2 mg on Vigilance and Cognitive Functions in the Elderly
The purpose of this study is to evaluate the effects of etifoxine (an anxiolytic) compared to lorazepam (a benzodiazepine anxiolytic) on vigilance and cognitive functions in the elderly.
- Trial name
- NCT02147548
- Testing
- etifoxine, lorazepam
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Biocodex
Alzheimer's Disease (AD)
The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
The investigators' goal is to determine if certain tests of memory and attention, performed while sleepiness is induced by a single dose of lorazepam, can predict whether or not an individual is at risk for developing Alzheimer's…
- Trial name
- NCT01780519
- Testing
- lorazepam
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Subjects
Acute Effect of Lorazepam on Brain Activity Measured by Magnetoencephalograpy (MEG) and Electroencephalography (EEG)
This placebo-controlled crossover study is intended to measure the effect of four doses of lorazepam on brain activity measured by magnetoencephalography (MEG) and electroencephalography (EEG).
- Trial name
- NCT01272778
- Testing
- Lorazepam
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Orasi Medical, Inc.