Clinical trials: Low Anterior Resection Syndrome
Faecal Incontinence With Faecal Urgency, Rectal Cancer
Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery
This study aims to assess and evaluate the clinical efficacy of an intensified form of Percutaneous tibial nerve stimulation (PTNS) compared to standard conservative treatment for low anterior resection syndrome (LARS).
- Conditions
- Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome (LARS>20)
- Trial name
- HiPLARS (NCT07862673)
- Testing
- Percutaneous Tibial Nerve Stimulation
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study
Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study.
- Trial name
- NCT07267767
- Testing
- nCRT, BMI, Distance from AV
- Volunteers
- 3,500 people
- Sponsor
- Northern Jiangsu People's Hospital
Low Anterior Resection Syndrome
Randomized Clinical Trial on Transanal Irrigation
Objective The primary objective is to demonstrate superiority of the Peristeen cone catheter compared to standard of care. The secondary objective is to investigate quality of life and different benefits and aspects of treatment…
- Trial name
- NCT04586634
- Testing
- Peristeen cone catheter
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Coloplast A/S
Low Anterior Resection Syndrome
Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery
A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel…
- Trial name
- NCT03215017
- Testing
- Transanal irrigation, Medication
- Where
- 3 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Mirna Abraham-Nordling
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Rectal Cancer
Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer.
The purposes of this study are to explore the trajectory of symptom distress and balance ability in patients with rectal cancer.
- Trial name
- NCT06006260
- Where
- Taiwan
- Volunteers
- 107 people
- Sponsor
- Chang Gung Memorial Hospital
Low Anterior Resection Syndrome
Acupuncture in Low Anterior Resection Syndrome Treatment
Acupuncture has it's role in treating patients with fecal incontinence and diarrhea-predominant irritable bowel syndrome. There is no trial or case-report assessing it's role in treatment of Low anterior resection syndrome.
- Trial name
- AcuLARS (NCT03916549)
- Testing
- Acupuncture
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Gastroenterology, LARS - Low Anterior Resection Syndrome
A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients
The purpose of this post-market clinical follow up study is to assess the efficacy on clinical symptoms of LARS of low volume Transanal Irrigation by MiniGo in conjunction with conservative treatment versus conservative treatment…
- Conditions
- Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer
- Trial name
- MINIGO (NCT06923150)
- Where
- 9 sites in France
- Volunteers
- 78 people
- Sponsor
- Qufora A/S
Low Anterior Resection Syndrome, Rectal Cancer
The Value of Botox-A for Management of Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is frequent after treatment for low rectal cancer. Increased bowel frequency and urgency with rectal spasms and incontinence have deleterious impacts on quality of life in a third of the…
- Trial name
- NCT01589471
- Testing
- intra-rectal Botulinum toxin A injection
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Low Anterior Resection Syndrome
International Low Anterior Resection Score Evaluation
Aim: The aim of this study is to perform a prospective, international 4 months cohort study evaluating bowel function before curative rectal cancer surgery and one year after the surgery using the LARS score.
- Trial name
- PrePostLARS (NCT04040842)
- Testing
- Patients undergoing low anterior resection
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Rectal Cancer, Low Anterior Resection Syndrome
Rectal Cancer Survivorship: Impact of Low Anterior Resection Syndrome (LARS) on the Quality of Life
Quality of life and risk factors for developing major LARS are explored. Therapeutic options were explored in the cohort experiencing major LARS
- Trial name
- NCT06059170
- Testing
- LARS score/ EORTC QLQ C30
- Where
- Belgium
- Volunteers
- 187 people
- Sponsor
- University Hospital, Ghent
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy
Effectiveness of Sacral Neuromodulation in Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is a complex disorder suffered by patients who undergo rectal resection mainly due to rectal cancer.
- Conditions
- Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy, Rectal Cancer
- Trial name
- SANLARS (NCT03598231)
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Low Anterior Resection Syndrome, Rectal Cancer
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).
- Trial name
- NCT04087421
- Testing
- Qufora Irrisedo Cone System, Glycerol "OBA"
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Anterior Resection Syndrome
Transanal Irrigation - Best Treatment Possibility for Low Anterior Resection Syndrome? Multicenter, Randomized Clinical Trial
Introduction: About 50% of patients who undergo rectal resection (mostly as a treatment for rectal cancer) suffer from various and partly severe functional problems, despite the preservation of the anal fold.
- Trial name
- NCT05920681
- Testing
- Transanal irrigation, Best supportive care
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Rectal Neoplasm
Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome
Low anterior resection syndrome refers to changes in bowel habits such as frequent defecation, urgent defecation, and fecal incontinence, which result in decreased bowel function.
- Trial name
- NCT07041515
- Testing
- Mobile app, standard
- Volunteers
- 320 people
- Sponsor
- National Cancer Center, Korea
Colorectal Cancer, Low Anterior Resection Syndrome
Effect of Exercise on Bowel Function in Colorectal Cancer Survivors
The survival rate of colorectal cancer patients is increasing due to the development of medical technology. However, many colorectal cancer survivors (CRCs) have bowel dysfunction unlike other cancer survivors.
- Trial name
- NCT05420870
- Testing
- exercise
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Anterior Resection Syndrome
Low Anterior Resection Syndrome and Rectal Irrigation Study
Prospective study assessing treatment acceptability and the impact of rectal irrigation on patients with low anterior resection syndrome (LARS) in terms of quality of life and bowel function.
- Trial name
- LARRIS (NCT04246775)
- Testing
- Peristeen
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cardiff and Vale University Health Board
Rectal Disorders, Low Anterior Resection Syndrome
Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome
The treatment of rectal cancer is currently based on surgical resection of the rectum with total excision of the mesorectum, associated with neoadjuvant radiochemotherapy.
- Conditions
- Rectal Disorders, Low Anterior Resection Syndrome, Low Anterior Resection
- Trial name
- LARS (NCT05368168)
- Testing
- Posterior tibial nerve stimulation (PTNS)
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Innovacion en Cirugía Vigo
Low Anterior Resection Syndrome, Rectal Cancer
Bowel Dysfunction 3 Years After Anterior Resection a in a Swedish National Cohort
The primary objectives are to evaluate the prevalence of LARS and Quality of Life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major LARS and to study…
- Trial name
- NCT04591821
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane