Clinical trials: Low Blood Pressure
Sepsis, Hypotension
Fluid Responsiveness Evaluation in Sepsis-associated Hypotension
This study assesses the mean difference in fluid balance at ICU discharge and associated patient outcomes, based on a dynamic assessment of fluid responsiveness in septic patients with refractory hypotension in an ICU setting.
- Trial name
- FRESH (NCT02837731)
- Testing
- Treatment Starling SV monitor
- Where
- 12 sites in United States, United Kingdom
- Volunteers
- 150 people
- Sponsor
- Cheetah Medical Inc.
Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation
Alveolar Recruitment Maneuver-Induced Hypotension: A Dynamic Consequence and Intraoperative Indicator of Fluid Responsiveness
This study investigates whether two simple bedside tests - the Passive Leg Raising (PLR) test and the Pleth Variability Index (PVI) - can predict a drop in blood pressure that sometimes occurs during a lung-opening procedure…
- Conditions
- Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation, Atelectasis, Fluid Responsiveness
- Trial name
- NCT07766967
- Testing
- Alveolar Recruitment Maneuver (ARM), Passive Leg Raising (PLR) Test
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Parkinson Disease
The Role of the Noradrenergic System in the Nonmotor Symptoms of Parkinson's Disease
The goal of this clinical trial is to learn about the role of noradrenergic system in the non-motor symptoms of Parkinson's disease. The main objectives it aims to answer are: 1.
- Trial name
- NAinPD (NCT04346394)
- Testing
- Yohimbine HCl
- Where
- United States
- Sponsor
- Nathaniel M. Robbins
Mandibular Prognathism, Mandibular Retrognathism
The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability
Deliberate hypotension is defined as lowering the systolic blood pressure to 80-90mmHg, or the mean blood pressure to 50-65mmHg.
- Trial name
- NCT01634594
- Testing
- Group R, Group N, Group D
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Neonatal Hypotension
Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants
The purpose of this study is to investigate the early use of hydrocortisone in hypotensive very low birth weight infants. Based on the observations that: hypotension is a common problem in very low birthweight infants and is…
- Trial name
- NCT00358748
- Testing
- Hydrocortisone
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Neurogenic Orthostatic Hypotension
Spinal Cord Stimulation for Neurogenic Orthostatic Hypotension
Neurogenic orthostatic hypotension is a disabling manifestation of synucleinopathies including Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, and pure autonomic failure.
- Trial name
- NCT07879391
- Testing
- Lower thoracic epidural spinal cord stimulation
- Volunteers
- 20 people
- Sponsor
- Aerospace Center Hospital
Hypotension During Surgery, Perioperative Complication
Hypotension Predictive Index Effect on Intraoperative Hypotension During Pancreatic Surgery.
Intraoperative hypotension (IOH) is a sudden clinical phenomenon that occurs frequently during general anesthesia. Prevention of IOH has been linked to reduced postoperative organ damage and decreased incidence of perioperative…
- Trial name
- EHPI-Pan (NCT06097052)
- Testing
- Hypotension Predictive Index
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Clinico Humanitas
Radiography, Interventional
Early Detection of Intra Operative Hypotension (IOH) During the Induction of General Anaesthesia
During general anaesthesia, intraoperative hypotension (IOH), defined as a mean arterial pressure (MAP) drop of more than 20%, is frequent with potential deleterious effects for patients.
- Trial name
- NCT03756935
- Testing
- All monitoring
- Volunteers
- 62 people
- Sponsor
- Hopital Lariboisière
Pregnant Women, Pain
Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia using hyperbaric bupivacaine which provides an adequate sensory and motor block.
- Conditions
- Pregnant Women, Pain, Hypotension
- Trial name
- NCT02973048
- Testing
- Hyperbaric bupivacaine, Hyperbaric prilocaine
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Extracorporeal Life Support, Hypotension
Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock
The cardiogenic shock is characterized by an alteration of organs function following a decrease in cardiac output linked to an impairment of cardiac performance. The prognosis remains poor with mortality between 40 and 50%.
- Conditions
- Extracorporeal Life Support, Hypotension, Vasoplegia
- Trial name
- RetroECMO-VP (NCT03968926)
- Testing
- Arterial pressure management during circulatory support by VA-ECMO
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Hypotension and Shock, Excessive Amount of Blood / Fluid Infusion
Predict Fluid Responsiveness in Spinal Anesthesia
Spinal anesthesia is still the regional anesthesia technique most widely employed in everyday clinical practice. The most feared and common of its well known side effects consist in an abrupt reduction of systemic vascular…
- Trial name
- CERU-1401 (NCT02070276)
- Testing
- Trans-thoracic echocardiography, Passive Leg Raising Test
- Where
- Switzerland
- Volunteers
- 429 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Hypotension on Induction
Perfusion Index as a Predictor of Postinduction Hypotension of General Anesthesia in Geriatric Patients
The influence of hemodynamic aberrations during anesthesia on adverse outcomes is an important clinical issue. There is evidence that hypotension and hypertension during general anesthesia are independently associated with…
- Trial name
- NCT04682717
- Testing
- perfusion index monitoring for postinduction hypotension
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intra-operative Hypotension
Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension
Hypotension is a common side-effect of general anesthesia induction and is related to adverse outcomes including significantly increasing risk of one-year mortality.
- Trial name
- NCT05784350
- Testing
- fluid boluses guided by IVC diameter via US/administration of pre-operative IV Odansetrone
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
Hypotension, Arterial Stiffness
Arterial Stiffness and General Anesthesia Induced Hypotension in Patients on Angiotensin-converting Enzyme Inhibitors
Induction of general anesthesia to the patient could be a challenging period of anesthesia management. Due to autonomic system suppression, hemodynamic fluctuation, such as hypotension or hypertension, is commonly seen during…
- Trial name
- NCT02416024
- Testing
- SphygmoCor system
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Iowa
Acute Respiratory Failure, Intubation Complication
Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
Complications are common during tracheal intubation of critically ill patients. Nearly one in five patients undergoing intubation in the intensive care unit experiences cardiovascular collapse, defined as severe hypotension…
- Conditions
- Acute Respiratory Failure, Intubation Complication, Hypotension on Induction
- Trial name
- PREPARE II (NCT03787732)
- Testing
- Fluid Bolus, No Fluid Bolus
- Where
- 11 sites in United States
- Volunteers
- 1,067 people
- Sponsor
- Vanderbilt University Medical Center
Spinal Cord Injury
Orthostatic Tolerance During FES (Functional Electrical Stimulation)-Walking in Paraplegia
Objective: The objective of this research is to undertake a safety and viability study of FES-evoked stepping in individuals with paraplegia.
- Trial name
- NCT00108043
- Testing
- FES-evoked functional upright gait
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- University of Sydney
Mechanical Ventilation Complication, Arterial Thrombosis
Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment
Investigators will conduct a pragmatic randomized trial to investigate the non-inferiority of restricted use of invasive arterial lines compared to standard arterial line use.
- Conditions
- Mechanical Ventilation Complication, Arterial Thrombosis, Limb Ischemia, Shock
- Trial name
- GRACE (NCT05411315)
- Testing
- Restricted-use of arterial catheter, Standard-use of arterial catheter
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Intra-operative Hypotension, Carotid Stenosis
Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Carotid endarterectomy (CEA) is the recommended treatment for symptomatic high degree stenosis of the internal carotid artery (ICA).
- Trial name
- NCT01451294
- Testing
- Administration of phenylephrine, Administration of ephedrine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- G.J. de Borst
Hypotension
Focussed Echocardiography to Detect Preoperative Hypovolemia and Left Ventricular Dysfunction as a Predictor of Post-Induction Hypotension
This is an observational study to evaluate the role of a Bed side Focus assessed Transthoracic Echocardiography (FATE) in identifying the patients at a potential risk of developing hypotension secondary to general anesthesia…
- Trial name
- NCT02944266
- Testing
- Pre operative Focus assessed Transthoracic echocardiographic assessment.
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh