Clinical trials: Low Dose
Inflammation, Healthy
Impact of Cottonseed Oil on Oxidative Stress, Inflammation, and Metabolism
Recent research evidence suggests that cottonseed oil (CSO) may have both direct and indirect anti-inflammatory and anti-oxidative impacts linked to bioactive components of CSO and favorable alterations in lipid metabolism.
- Conditions
- Inflammation, Healthy, Oxidative Stress, Metabolic Syndrome
- Trial name
- NCT05439590
- Testing
- High dose CSO, Low dose CSO, Low dose OO
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Montana State University
Healthy
Comparison of the Effects of Injectable Platelet-rich Fibrin and Low-dose Laser Applications on Palatal Wound Healing.
The investigators will evaluate the findings related to pain and bleeding, quality of life after surgery, and wound healing in participants who received injectable platelet-rich fibrin (i-PRF) and low-dose laser therapy to the…
- Trial name
- NCT06744270
- Testing
- i-PRF group, low-dose laser group
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Esra Bozkurt
Lung Cancer Screening
Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America(LUCAS-LATAM)
Prospective study to assess lung cancer screening with low dose CT scan (LDCT) in Latin America (LATAM) and prospectively evaluate chest-XRay analyzed with artificial intelligence (AI) using qXRin (QURE ai) at the initial visit…
- Trial name
- LUCAS-LATAM (NCT07524803)
- Testing
- Chest X-Ray, Low Dose CT scan
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Latin American Consortium for the Lung Cancer Research
Healthy
Pharmacokinetics and Pharmacodynamics of Sertraline After Low Dose Administration
This study aimed to explore the pharmacokinetics and pharmacodynamics of low dose sertraline with [11C] sertraline positron emission tomography (PET) study.
- Trial name
- NCT00969852
- Testing
- Sertraline
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Platelet Reactivity
Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.
Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients.
- Trial name
- NCT03679091
- Testing
- low-dose ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Virtual Reality Therapy
Modifying Virtual Reality Analgesia With Low-Dose Pain Medication
The purpose of this study is to determine how pain relief is modified when the investigators combine the Virtual Reality based Snow World game with certain pain medications.
- Trial name
- NCT01840774
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tetanus, Diphtheria
An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster
Open-label, randomized, multi-centre study in which 400 subjects, divided into two groups, will receive Td5ap or Td1aP as a single injection.
- Conditions
- Tetanus, Diphtheria, Pertussis
- Trial name
- Tdap Booster (NCT00870350)
- Testing
- Td5ap, Td1aP
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Swedish Institute for Infectious Disease Control
Adrenal Insufficiency
Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon
Previous study showed that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test.
- Trial name
- NCT03074123
- Testing
- low-dose cosyntropin stimulation test
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Airway Inflammation
Study of Biomarkers of Airway Inflammation (0000-128)
This study will evaluate the effects of inhaled fluticasone on cell counts and inflammatory mediators measured in sputum of healthy volunteers following exposure to inhaled lipopolysaccharide.
- Trial name
- NCT00869596
- Testing
- fluticasone propionate, Comparator: Lipopolysaccharide (LPS), Comparator: albuterol
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Pain
Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting
This project is a pilot study to evaluate the analgesic and opioid-sparing effects of ketamine in an ultra-low dose oral formulation as a novel intervention for treatment of chronic non-cancer pain in opioid-tolerant patients in…
- Trial name
- Ketamine (NCT02303847)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Low Dose Calcium to Prevent Preeclampsia
The purpose of this study is to assess, in pregnant women with calcium-poor diets, what is the effectiveness of low-dose (500 mg/day) calcium supplements associated with an educational intervention, compared to the educational…
- Conditions
- Pre-Eclampsia, Hypertension, Pregnancy-Induced, Dietary Calcium Deficiency
- Trial name
- AMCAL (NCT02338687)
- Testing
- calcium, Educational sessions
- Where
- Brazil
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Covid19
the Investigation Into Beneficial Effects of High-dose Interferon Beta 1-a, Compared to Low-dose Interferon Beta 1-a in Moderate to Severe Covid-19
The present study is a randomized clinical trial, with the approval of the ethics committee will be conducted on patients who have a positive test confirming COVID-19 in Loghman Hakim Medical Education Center in Tehran.
- Trial name
- NCT04521400
- Testing
- High dose Interferon-beta 1a, Lopinavir/Ritonavir, Low dose Interferon-beta 1a
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
LDL - Low Density Lipoprotein Receptor Disorder, Rosuvastatin
Impact of Rosuvastatin Doses on LDL Levels, CPK Levels and Aspartate Aminotransferase Levels
Particpants were divided into groups based on doses of rosuvastatin and were assessed and for CPK, LDL and AST levels
- Trial name
- NCT06910098
- Testing
- Rosuvastatin
- Where
- Pakistan
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Central Park Medical College
Ultra-low-dose CT, Thoracic
Fast Ultra Low Dose CT Interpretation
An ultra-low-dose CT(ULDCT) image viewer prototype was developed in an iterative fashion that aims to reduce average interpretation times of ULDCT images.
- Trial name
- NCT05748184
- Testing
- ULDCT PACS prototype, PACS viewer prototype, Optimized ULDCT viewer prototype version(s)
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Lung Cancer
Image Discovering Early Lung Cancer Project
Lung cancer is the leading cause of cancer related death in Taiwan and world wide. The application of low dose helical computed tomography (CT) has been the milestone of lung cancer screening.
- Trial name
- IDEALCAP (NCT01914458)
- Testing
- Low-dose computed tomography (LDCT)
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Colorectal Cancer
Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects
This study is to investigate the effect of various modified low volume polyethylene glycol (PEG) 3350 and ascorbic acid/ascorbate (PEG+ASC)-based gut cleansing solutions on stool output in healthy subjects.
- Trial name
- OUT (NCT01834742)
- Testing
- NER1006, Moviprep
- Where
- 2 sites in Romania
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Norgine
Breast Cancer
Low-dose Imaging Technique (LITE)
The purpose of this study is to compare the diagnostic accuracy of a breast MRI when using a smaller dose of contrast compared to a full dose of contrast.
- Trial name
- NCT04350957
- Testing
- Low-dose Imaging
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Rheumatoid Arthritis
An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective
This study will evaluate the optimal dose of tofacitinib needed to achieve low disease activity (LDA) or clinical remission as measured by the CDAI score.
- Trial name
- NCT02566967
- Testing
- tofacitinib
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Norman B. Gaylis, MD
Osteopenia, Osteoporosis
Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis
Osteoporosis, a condition in which bones are fragile and break easily, is a major health problem for postmenopausal women. Research studies have shown that both estrogen/progestin replacement therapy (hormone replacement therapy…
- Trial name
- NCT00000430
- Testing
- Alendronate, Estrogen/progestin therapy
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Proliferative Vitreoretinopathy
Isotretinoin for Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy (PVR), or secondary scarring on and around the retina, is an important cause of retinal re-detachment.
- Trial name
- DELIVER (NCT01445028)
- Testing
- Isotretinoin
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Wills Eye