Clinical trials: Low Grade
Low-grade Glioma
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory…
- Trial name
- NCT03948490
- Testing
- ReMind iPad app, Healthy SMS texting, In-person cognitive rehabilitation
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of California, San Francisco
Brain Tumor Adult
Intraoperative Ultrasound for Brain Tumor Surgery Enhanced by AI
Intraoperative ultrasound is a versatile, low-cost imaging tool that has been shown to improve safety and efficacy in brain tumor surgery.
- Trial name
- BrainUS-AI (NCT07376304)
- Testing
- BrainUS-AI real-time intraoperative ultrasound segmentation system
- Volunteers
- 100 people
- Sponsor
- Hospital del Rio Hortega
Brain and Central Nervous System Tumors
Magnetic Resonance Imaging in Treating Children With Progressive Low-Grade Astrocytoma
RATIONALE: New imaging procedures such as magnetic resonance imaging may improve the ability to determine the growth rate of progressive astrocytoma.
- Trial name
- NCT00005084
- Testing
- conventional surgery, magnetic resonance spectroscopic imaging, radiation therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Alcohol Consumption, Inflammation
Effect of Alcohol Consumption on Markers of Inflammation
Rationale: High-density lipoprotein (HDL), which is consistently increased after moderate alcohol consumption, is an abundant plasma lipoprotein that is generally thought to be anti-inflammatory in both health and infectious…
- Trial name
- AR23 (NCT00918918)
- Testing
- Alcohol + orange juice, Orange juice
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Cervical Intraepithelial Neoplasia Grade 1 (CIN 1)
Diagnostic and Prognostic Value of p16INK4a Expression in Low Grade Squamous Intraepithelial Lesions of the Cervix.
P16INK4a has recently been described as a surrogate marker for HR-HPV associated squamous and glandular intraepithelial lesions of the cervix.
- Trial name
- NCT00343213
- Testing
- colposcopy
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Glioma, Glioma, Malignant
Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery
This retrospective study aims to assess the utility of 2D non-navigated intraoperative ultrasound (ioUS) as a cost-effective alternative for guiding the surgical resection of gliomas and for detecting residual tumor.
- Conditions
- Glioma, Glioma, Malignant, Low-grade Glioma, High-grade Glioma
- Trial name
- 2D-ioUS-Glio (NCT05873946)
- Testing
- intraoperative ultrasound
- Where
- Spain
- Volunteers
- 99 people
- Sponsor
- Hospital del Rio Hortega
Chronic Pain, Manipulation
Comparison of the Effect of Spine Grade I and II Manipulation and a PNE Video on Brainwaves: Pilot Study
The purpose of this study is to determine the effect of the use of a pain neuroscience educational video instruction on brainwave activity and compare this to the effects of a grade I \& II PA spinal oscillations of the spine…
- Conditions
- Chronic Pain, Manipulation, Psychologic
- Trial name
- NCT04908670
- Testing
- Understanding Pain in less than 5 minutes, and what to do about it! https://www.youtube.com/watch?v=C_3phB93rvI, PA manipulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
HPV Infection, HPV Integration
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection.
- Conditions
- HPV Infection, HPV Integration, HPV Disease, HPV Genital Infection
- Trial name
- NCT07697196
- Testing
- Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele
Glioma
Angiogenic Profile and Non-invasive Imaging May Predict Tumor Progression of High Risk Group Low Grade Glioma (LGG)
The low grade glioma (LGG) is a type of brain tumor which is generally more common in younger age group patients. Most patients with LGG undergo surgery which is mostly incomplete due to concern about loss of function.
- Trial name
- NCT00137488
- Testing
- imaging and angiogenic profiles
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- AHS Cancer Control Alberta
Brain and Central Nervous System Tumors
Study of Tissue and Blood Samples From Patients With Low-Grade Glioma
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01004523
- Testing
- fluorescence in situ hybridization, loss of heterozygosity analysis, polymerase chain reaction
- Where
- 38 sites in United States
- Volunteers
- 135 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Bladder Cancer
Intravesical Gemcitabine and Docetaxel for Low Grade Intermediate Risk Bladder Cancer
Bladder cancer is the 8th most common cancer in the UF Health Cancer Center catchment area and the 7th most common cancer presenting to UFHealth.
- Trial name
- NCT06488222
- Testing
- Docetaxel, Gemcitabine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Florida
Glioma, Glioblastoma
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype
Background: Gliomas are the most common malignant brain tumors. Some have certain changes (mutations) in the genes isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2).
- Conditions
- Glioma, Glioblastoma, High Grade Glioma, Low Grade Glioma
- Trial name
- NCT03718767
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Cancer
Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations
This was a 4-part (Part A, Part B, Part C and Part D), Phase I/IIa, multi-center, open label, study in pediatric subjects with refractory or recurrent tumors.
- Trial name
- NCT02124772
- Testing
- Trametinib, Dabrafenib
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 139 people
- Sponsor
- Novartis Pharmaceuticals
Barretts Esophagus With Low Grade Dysplasia, Dysplasia
Acetic Acid for the Detection of Esophageal Neoplasms
Barrett's esophagus is a complication of chronic gastroesophageal reflux disease that occurs in up to 10% to 15% of patients with this pathology.
- Conditions
- Barretts Esophagus With Low Grade Dysplasia, Dysplasia, Intestinal Metaplasia
- Trial name
- NCT04054713
- Testing
- Acetic acid chromoendoscopy, Seattle protocol
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Brain Tumors
A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas
This study is for patients up to 21 years of age who have a tumor called a low grade glioma of the central nervous system (brain and spinal cord). The tumor has grown despite attempts to control it with chemotherapy or radiation.
- Trial name
- Poly-ICLC (NCT01188096)
- Testing
- Poly ICLC
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences
Glioma, Low-grade Glioma
Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas
The purpose of this research study is to learn if the study drug RAD001 can shrink or slow the growth of low-grade gliomas. Additionally, the safety of RAD001 will be studied.
- Conditions
- Glioma, Low-grade Glioma, Astrocytoma
- Trial name
- NCT00782626
- Testing
- everolimus
- Where
- 10 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Cervical Intraepithelial Neoplasia Grade I/ II/ III (CIN I/II/III), Human Papillomavirus (HPV) Infections
A Study to Assess the Reduction of Human Papillomavirus (HPV) Viral Infectivity and Transmission in HPV-Positive Women After Vaccination With 9vHPV (RIFT-HPV)
This is a non-randomized, open label study to assess the reduction of Human Papillomavirus (HPV) infectivity and transmission in women positive for HPV16 and/or 18 in a cervical, oral and anal sample and vaccinated with…
- Conditions
- Cervical Intraepithelial Neoplasia Grade I/ II/ III (CIN I/II/III), Human Papillomavirus (HPV) Infections, High-risk HPV, HPV-16/ 18
- Trial name
- RIFT-HPV (NCT05334706)
- Testing
- Nonavalent HPV vaccine (9vHPV/Gardasil-9™).
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- Miquel Angel Pavon Ribas
Adult Diffuse Astrocytoma, Adult Mixed Glioma
Everolimus in Treating Patients With Recurrent Low-Grade Glioma
This phase II trial studies how well everolimus works in treating patients with recurrent low-grade glioma. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood…
- Conditions
- Adult Diffuse Astrocytoma, Adult Mixed Glioma, Adult Oligodendroglioma, Adult Subependymal Giant Cell Astrocytoma
- Trial name
- NCT00823459
- Testing
- Everolimus, Archival Tissue Analysis
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Susan Chang
Latent Tuberculosis, Diabetes Mellitus, Type 2
Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation
This study will be investigating the effect of latent tuberculosis infection (LTBI) treatment on glucose tolerance and low-grade inflammation.
- Trial name
- NCT04830462
- Testing
- Rifampicin 300 Mg Oral Capsule, Isoniazid 300 Mg ORAL TABLET
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Herlev and Gentofte Hospital
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
The LINFU® U.S. Registry for the in the General Population Without Risk Factors
Adenocyte has developed LINFU®, (Low Intensity Non-Focused Ultrasound excitation of the pancreas) as a method of identifying early, asymptomatic pancreatic cancer and its noninvasive precancerous lesions..
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Dysplasia
- Trial name
- NCT06276803
- Testing
- LINFU®
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Adenocyte, LLC