Clinical trials: Low Mood
Depression, Anxiety, Stress
A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana
"A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana" is intended to help mitigate stressors that may contribute to poor behavioral and mental health in rural Montana teachers.
- Trial name
- NCT05085392
- Testing
- Trauma-Informed Yoga
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Montana State University
Major Depressive Disorder
Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder
This is an outpatient study to evaluate the safety, and efficacy of RGH-188 as an add-on therapy to standard antidepressants in patients who did not respond to previous antidepressant therapy.
- Trial name
- NCT00854100
- Testing
- Antidepressant + cariprazine (0.1-0.3 mg/day), Antidepressant + cariprazine (1-2 mg/d)
- Where
- 41 sites in United States
- Volunteers
- 231 people
- Sponsor
- Forest Laboratories
Bipolar Depression
Evaluate the Efficacy and Safety of Quetiapine Fumarate (SEROQUEL) Extended Release as Monotherapy in the Treatment of Patients With Bipolar Depression
The primary objective of this study is to evaluate the superior efficacy of quetiapine extended release(XR) mono-therapy, administered once daily compared to placebo, in the treatment of depressive symptoms in patients with…
- Trial name
- NCT01256177
- Testing
- Quetiapine Fumarate (SEROQUEL) Extended Release
- Where
- 12 sites in China
- Volunteers
- 361 people
- Sponsor
- AstraZeneca
Self-Injurious Behavior, Self Harm
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
The purpose of this study is to explore the tolerability and effectiveness of transcranial direct current stimulation (tDCS) as a potential treatment for non-suicidal self-injury (NSSI).
- Conditions
- Self-Injurious Behavior, Self Harm, Self-injury, Self-inflicted Injury
- Trial name
- NCT04244786
- Testing
- Transcranial direct current stimulation, No intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Emotional Disorders, Anxiety Disorders
A Unified Treatment for Anxiety Disorders
The purpose of this study is to develop a new psychological therapy for a variety of different types of emotional disorders. The study will compare symptoms and functioning of clients who receive the treatment with those who do…
- Trial name
- NCT00586001
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
- Volunteers
- 37 people
- Sponsor
- Boston University Charles River Campus
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (Levomilnacipran SR) in Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER compared to placebo in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT01377194
- Testing
- Levomilnacipran ER
- Where
- 51 sites in United States, Canada
- Volunteers
- 568 people
- Sponsor
- Forest Laboratories
Depression
Veteran Peer-Assisted Computerized Cognitive Behavioral Therapy for Depression
The investigators will conduct a randomized clinical trial of Peer-Supported cCBT versus enhanced usual care (EUC) for 330 patients with new episodes of depression in primary care at three VA sites and their associated…
- Trial name
- NCT02057042
- Testing
- Peer-assisted computerized CBT, Enhanced usual care
- Where
- 3 sites in United States
- Volunteers
- 330 people
- Sponsor
- VA Office of Research and Development
Depression, Postpartum
Efficacy and Safety Study of NeuroStar TMS Therapy in Patients With Major Depressive Disorder With Postpartum Onset
The purpose of this study is to evaluate the safety and effectiveness of acute NeuroStar TMS therapy in women who have postpartum depression.
- Trial name
- NCT01842542
- Testing
- NeuroStar Transcranial Magnetic Stimulation (TMS)
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- Neuronetics
HIV/AIDS, Methamphetamine Abuse
Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
This study is a single-arm, non-randomized pilot study. Eligible participants are newly enrolled participants in an outpatient methamphetamine treatment program, and study activities will take place contemporaneously with…
- Conditions
- HIV/AIDS, Methamphetamine Abuse, Depression
- Trial name
- NCT03864653
- Testing
- MoodGym
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Friends Research Institute, Inc.
Misinformation, Vaccine Hesitancy
Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depression
The COVID-19 pandemic has led to a mis/disinformation ecosystem that promotes divergent views of vaccine efficacy, as well as the legitimacy of science and medicine.
- Conditions
- Misinformation, Vaccine Hesitancy, Anxiety, Depression
- Trial name
- NCT06119854
- Testing
- Attitudinal inoculation, Cognitive-behavioral therapy-informed intervention, Conventional public health messaging
- Where
- United States
- Volunteers
- 1,419 people
- Sponsor
- City University of New York, School of Public Health
Depression, HIV
Trial of Collaborative Depression Care Management for HIV Patients
This project will integrate a depression treatment and brief medication adherence counseling intervention into clinical care at three HIV clinics and will use a randomized controlled trial to assess whether, relative to usual…
- Trial name
- SLAM DUNC (NCT01372605)
- Testing
- Measurement-Based Care collaborative depression management, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- Duke University
Depression, Marijuana Abuse
Free Venlafaxine Treatment for Marijuana Addiction and Depression - 1
The purpose of this study is to determine if Venlafaxine Extended Release (Ven-XR) is effective in treating individuals with marijuana addiction and depression.
- Trial name
- VEN (NCT00131456)
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- New York State Psychiatric Institute
Depression
An Evaluation of Safety and Feasibility Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression
The objective of this investigation is to examine the safety and feasibility of a series of repetitive transcranial magnetic stimulation (rTMS) treatments (10 Hertz [Hz]; Left Dorsolateral Prefrontal Cortex), with a Neuronetics…
- Trial name
- NCT00587639
- Testing
- rTMS Treatment
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol Use Disorder, Inflammatory Response
An Inflammatory Challenge Using Endotoxin
The study design consists of a randomized, double-blind, placebo-controlled trial of low dose endotoxin. The low dose endotoxin challenge induces a transient systemic inflammatory response with normalization of cytokine levels…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
- Trial name
- NCT04310423
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Treatment-resistant Depression
Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression
About one-third of depressed patients will not get better after multiple antidepressant treatments. This situation put a high burden on patients with depression due to worsening quality of life and increasing health care costs.
- Trial name
- NCT02360280
- Testing
- ketamine, midazolam
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- VA Office of Research and Development
Depression, Anxiety, Engagement, Patient
Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design
The overarching goals of this project are to provide the first rigorous test of a scalable and publicly accessible mobile health intervention (IntelliCare) to address emotional distress in women with breast cancer, and to test…
- Trial name
- NCT04583891
- Testing
- IntelliCare, Psychoeducation, Coaching
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- University of Virginia
Depression, Panic Disorder
Special Investigation Of Long Term Use Of Sertraline.
Special investigation of long term use of sertraline, 52 Week Observation, Long-Term Safety. The objective of this "Special investigation" is to collect information about 1) adverse drug reactions not expected from the LPD…
- Trial name
- NCT00605813
- Testing
- Sertraline hydrochloride
- Volunteers
- 542 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Major Depressive Disorder
Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)
The objective of this study is to allow patients who have participated in the precursor study of BCI-024 in combination with BCI-049 versus placebo or BCI-024 alone (Protocol #CBM-IT-01) to receive 6 weeks of open-label treatment…
- Trial name
- NCT00731653
- Testing
- Combination Product: BCI-024 + BCI-049
- Where
- 9 sites in United States
- Volunteers
- 81 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Chronic Pain Trial)
This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design.
- Trial name
- ADOPT PGx (NCT05966142)
- Testing
- Pharmacogenetic testing, Clinical decisions support
- Where
- 10 sites in United States
- Volunteers
- 1,048 people
- Sponsor
- Duke University
Depressive Symptoms, Quality of Life
Testing TRUST Depression Management Intervention
This study evaluates the effectiveness of a novel depression self-management intervention in adolescents with depression.
- Trial name
- TRUST (NCT03599141)
- Testing
- Trust-building Self-management Together, Depression Management
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.