Clinical trials: Low Ovarian Reserve
Fertility Issues
Follicular FSH Serum Level as a Predictor of an Oocyte Yield and Quality in Fertility Preservation Cycles for Women With a Compromised Ovarian Reserve
The incorporation of ovarian reserve tests in IVF management started after initial publications indicating a potential role for basal FSH in predicting pregnancy outcome after IVF and in counseling patients (1,2).
- Trial name
- NCT05536999
- Testing
- Blood sample taking , like to measure hormonal level like LH, FSH, Perlakan ,in a follicular fluid after the oocyte retrival
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Infertility
RCT of Low-dose Clomiphene vs. High Dose Gonadotropin Protocol for IVF Poor Responders
The purpose of this study is compare two commonly-used medication protocols ( low-dose clomiphene citrate and high dose gonadotropin protocols) for the treatment of patients with diminished ovarian reserve (decreased number of…
- Trial name
- CLOVANT (NCT01577199)
- Testing
- Low-dose Clomiphene, High dose gonadotropins
- Sponsor
- Weill Medical College of Cornell University
Infertility Low Over Reserve, IVF
BPA Levels Relationship With IVF/ICSI Outcomes in Low Ovarian Reserve
The relationship between BPA elevation in urine, blood, and follicle fluid and embryo quality, IVF/ICSI outcomes.
- Conditions
- Infertility Low Over Reserve, IVF, Infertility, Female
- Trial name
- NCT04654598
- Testing
- BPA levels
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Nefise Nazlı YENIGUL
Diminished Ovarian Reserve
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed.
- Trial name
- DPOS (NCT05847283)
- Testing
- Dydrogesterone priming ovarian stiumulation protocol, GnRH antagonist protocol
- Where
- 2 sites in Vietnam
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Tam Anh TP. Ho Chi Minh General Hospital
Infertility
Follicle Activation by Inhibition of the Hippo Pathway
The aim of this project is to activate recruitment and growth of resting primordial follicles in the ovaries of women with diminished ovarian reserve, in attempt to increase the chance to become pregnant, either naturally or…
- Trial name
- NCT02792569
- Testing
- Biopsy of ovarian cortical tissue
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Anders Nyboe Andersen
Primary Ovarian Insufficiency, Low Ovarian Reserve
Rejuvenation of Premature Ovarian Failure With Stem Cells
The ROSE-1 study is designed to determine the efficacy of bone marrow derived stem cell therapy on ovarian function recovery in subjects with idiopathic and other types of premature or primary ovarian failure (POF or POI) and low…
- Conditions
- Primary Ovarian Insufficiency, Low Ovarian Reserve, Premature Ovarian Failure
- Trial name
- ROSE-1 (NCT02696889)
- Testing
- ROSE-1 Protocol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Illinois Chicago
Diminished Ovarian Reserve
In Vitro Oocyte Maturation With Autologous Exosomes in Women
This study is a preliminary, prospective, randomized, controlled clinical trial designed to evaluate the safety and feasibility of supplementing in vitro maturation (IVM) media with autologous exosomes in women with diminished…
- Trial name
- Exosom2025-1 (NCT07249411)
- Testing
- MI oocytes were cultured in conventional IVM medium supplemented with 10 µg of autologous exosomes obtained using the ExoSMarT® exosome filtration system
- Where
- Venezuela
- Volunteers
- 32 people
- Sponsor
- Biotech Fertility C.A.
Premature Ovarian Insufficiency, Infertility, Female
Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation
The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs.
- Conditions
- Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP
- Trial name
- OPIF (NCT05279560)
- Testing
- autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- University of Luebeck
Female Infertility Due to Diminished Ovarian Reserve
Use of Dehydroepiandrosterone (DHEA) in Women With Normal and Poor Ovarian Reserve Undergoing IVF
The aim of the study is to evaluate the effect of DHEA supplement on ovarian reserve markers, ovarian response to gonadotrophins and cycle outcomes in patients with normal and poor ovarian reserve. Study Hypotheses: 1.
- Trial name
- NCT01915186
- Testing
- Dihydroepiandrosterone (DHEA)
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Poor Ovarian Response
Long-term Endogenous Androgen Priming in Bologna Criteria Poor Responder Patients - A Pilot Study
Until now no scientific clinical evidence exists regarding the possible impact of long term endogenous androgen priming in IVF patients aligned with the Bologna Criteria, in specific the impact of priming on serum parameters…
- Trial name
- NCT03447184
- Testing
- Androgen priming
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Mỹ Đức Hospital
Low Ovarian Reserve, Poor Ovarian Response
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)
This study aims to compare different ovulation triggering strategies in women with low ovarian reserve undergoing fresh in vitro fertilization (IVF) cycles.
- Trial name
- TRIGGERBEST (NCT07816562)
- Testing
- Human chorionic gonadotropin (hCG), Follitropin delta, Triptorelin
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia