Clinical trials: Low Ovarian Reserve
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Poor Ovarian Response
A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve
Assisted reproductive technology (ART), especially controlled ovarian stimulation (COS), significantly increased clinical pregnancy rates among infertile patients.
- Trial name
- NCT04717752
- Testing
- Ovidrel, Troprilin
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Nanjing University
Ovarian Stimulation
Mechanical Stimulation of the Ovary for Infertility Treatment in Patients With Very Low Ovarian Reserve
Examine the possibility that mechanical stimulation and ovarian fragmentation in women with premature ovarian failure or low ovarian reserve intended for egg donation may cause early follicular recruitment and increase chances of…
- Trial name
- NCT03298750
- Testing
- Resection of ovarian tissue and mechanical stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Low Ovarian Reserve, Poor Responders to Gonadotropihins Treatment
Can Dormant Perimenopausal Ovarian Follicles Become FSH Responsive?
The purpose of this study to obtain ovarian cortical fragments from perimenopausal patients, who undergo pelvic organ surgery and test whether treatment with PTEN inhibitor and PI3K activating peptide would induce these fragments…
- Trial name
- NCT01201226
- Testing
- Removal of half an ovary
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Infertility
Comparison of 2 Ovarian Stimulation Protocols for Women With Low Ovarian Reserve
The purpose of this study is to determine whether minimal ovarian stimulation for in vitro fertilization is superior to high dose stimulation. Number of mature eggs, number of embryos as well as pregnancy rates will be compared.
- Trial name
- NCT02128360
- Testing
- Letrozole, Gonadotropins, Gonadotropins
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
GH, Low Ovarian Reserve
To Explore the Effect of GH Pretreatment on Clinical Outcomes in Patients With Low Ovarian Reserve
Growth hormone (GH) has been used in the field of assisted reproduction technology for over 30 years. Studies for GH have been exploring in the applicable population, drug dosage, starting time and time limitation.
- Trial name
- NCT04384783
- Testing
- growth hormone
- Volunteers
- 114 people
- Sponsor
- Guangzhou First People's Hospital
Infertility
In Vitro Maturation With in Vitro Fertilization (IVF) Compared to Mild in Vitro Fertilization
Methods of infertility treatment may involve in vitro fertilization or IVF. Though effective, IVF is complex and expensive. Methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation…
- Trial name
- IVM vs IVF (NCT00867763)
- Testing
- In vitro maturation and in vitro fertilization, Low doses of gonadotropin stimulation.
- Where
- 2 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Batzofin Fertility Services
Diminished Ovarian Reserve (DOR)
Testing Herbal Pretreatment For IVF Success In Women With Low Ovarian Reserve
The goal of this clinical trial is to learn if a traditional Chinese herbal pretreatment can improve pregnancy outcomes in infertile women with diminished ovarian reserve (DOR) who are undergoing in vitro fertilization (IVF) or…
- Trial name
- PRIME (NCT07347340)
- Testing
- Bushen Tongzhi Formula
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Peking Union Medical College Hospital
Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV
Follicular Flushing Using Double Lumen Needle Versus Direct Aspiration in Low Prognosis Patients According to the POSEIDON Criteria
This is a prospective, randomized, controlled clinical trial designed to evaluate whether follicular flushing increases the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration in patients with poor…
- Conditions
- Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV, Poor Response to Ovulation Induction
- Trial name
- FLUSHING (NCT07270081)
- Testing
- follicular flushing, follicular aspiration
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Bernabeu
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Low Ovarian Reserve
The aim of this trial is to examine the possible effects of hCG administration for eight weeks prior to IVF/ICSI in women with low ovarian reserve.
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization
- Trial name
- NCT04643925
- Testing
- Ovitrelle
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
GH, Poor Ovarian Reserve Based on POSEIDON
To Explore the Effect of GH on Outcomes of IVF and Telomerase Activity of Granulosa Cells in Women With POR
It is still a big difficult clinical problem for patients with poor ovarian reserve undergoing in vitro fertilization. The decrease in both quality and quantity of egg are the main cause for poor clinical prognosis.
- Trial name
- NCT04384744
- Testing
- growth hormone
- Volunteers
- 40 people
- Sponsor
- Guangzhou First People's Hospital
Low Ovarian Reserve
Influence of PRGF (Plasma Rich in Growth Factors) Puncture in Ovaries With Low Follicular Reservetechniques
Assisted reproduction patients candidates to an IVF/ICSI cycle with low follicular reserve: after at least one cycle of stimulation obtaining 0-4 oocytes.
- Trial name
- PRGFO-2020 (NCT02992756)
- Testing
- Growth Factors
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- IVI Bilbao
Ovarian Reserve, Endometrioma, PTEN-AKT-FOXO3 Gene Expression
PTEN-AKT-FOXO3 Gene Expression Relation With Low-ovarian Reserve in Endometriomas
In this study, we aimed to investigate the relationship between PTEN-AKT-FOXO3 gene expression and decrease in ovarian reserve in the presence of endometrioma and other benign ovarian pathologies.
- Trial name
- NCT04058912
- Testing
- PTEN-AKT-FOXO3 Gene Expression
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uludag University
Ovarian Cancer
Salpingectomy vs Tubal Sterilisation in Low Risk for Ovarian Cancer Women and Its Effect on Ovarian Reserve
Randomised study to investigate if salpingectomies done to women wishing tubal sterilisation has an effect on ovarian reserve.
- Trial name
- NCT01888159
- Testing
- Bilateral Salpingectomy, Tubal sterilization with bipolar energy
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karlstad Central Hospital
Low Ovarian Reserve
Open, Non-comparative Pilot Study to Evaluate the Safety and Efficacy of Intraovarian Plasma Rich in Growth Factors (PRGF) in Patients With Low Ovarian Reserve
The use of plasma rich in growth factors (PRGF) improves ovarian reserve markers and IVF laboratory parameters in women with low ovarian reserve.
- Trial name
- NCT06975683
- Testing
- Plasma Rich in Growth Factors (PRGF)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Low Ovarian Reserve, Poor Quality Oocytes
Improving the Reproductive Outcome of Poor Quality Ova by Injection of Autologous Somatic Mitochondria
A prospective randomized controlled trial (RCT) to determine the effect of injecting an autologous somatic mitochondria concentrate, together with the spermatozoon during ICSI, into oocytes of older and or poor prognosis in vitro…
- Trial name
- NCT01631578
- Testing
- Injection of an autologous mitochondria to the oocyte.
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Hypogonadism; Ovarian, Female Infertility
Effect of 12 Weeks of Acupuncture on AMH and COH in Low Responder Patients
the investigators want to study whether 12 weeks of acupuncture has any effect on AMH and the ovarian reserve in women with low ovarian reserve (low responders).
- Trial name
- NCT03080584
- Testing
- acupuncture
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Dansk Fertilitetsklinik
Infertility, Infertility Unexplained
PMA-FERTITHEQUE Biocollection
Creation of a patient library in Medically Assisted Procreation to allow the implementation of further research with the following objectives: To identify new relevant biomarkers in patients who will carry a pregnancy to term To…
- Trial name
- FERTITHEQUE (NCT05599724)
- Testing
- Biocollection
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Low Ovarian Reserve
The Effect of Growth Hormone in Assisted Reproductive Technology Clinical Outcome of Poor Responder
Assisted reproduction treatment in patients with low ovarian reserve is a big difficult clinical problem. Growth hormone (GH) is crucial in the development of follicles since preantral follicle to ovulation and can promote…
- Trial name
- NCT03027843
- Testing
- Growth Hormone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Female Infertility
Effectiveness of Low Dose Gonadotropin Stimulation Protocol Vs High Dose Gonadotropin Protocol in Poor Responders
In the present study we examined the effect of addition of CC to a low dose gonadotropin (150 IU/day) / GnRH antagonist protocol in comparison to a high gonadotropin dose (300 IU/day) regiment (short protocol) in women with poor…
- Trial name
- NCT06778733
- Testing
- Clomiphane citrate, recombinant human Follicle-Stimulating Hormone (r-FSH-alfa)
- Where
- 2 sites in Greece
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Athens