Clinical trials: Low Risk Acute Graft-versus-host Disease, open to volunteers
Intensive Chemotherapy Unfit, Newly Diagnosed Acute Myeloid Leukemia (AML)
Alternating Regimen of VA and Low-dose CHA in the Treatment of Unfit Newly Diagnosed AML
This phase II trial tests how well VA alternating with low-dose CHA works in treating unfit patients with newly diagnosed acute myeloid leukemia (AML).
- Conditions
- Intensive Chemotherapy Unfit, Newly Diagnosed Acute Myeloid Leukemia (AML), Age ≥60
- Trial name
- CHANCE (NCT07172204)
- Testing
- Alternately treated with VA/low CHA regimen
- Where
- 5 sites in China
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
Randomized Trial in Adult de Novo Ph Positive ALL With Chemotherapy, Imatinib or Ponatinib, Blinatumomab and SCT
The current Standard of Care (SoC) in younger patients with Ph+ ALL is Imatinib in combination with low-dose chemotherapy, change of TKI in case of persistent MRD above 10-3 after consolidation I and indication for stem cell…
- Trial name
- GMALL-EVOLVE (NCT06061094)
- Testing
- Imatinib, Ponatinib, Blinatumomab
- Where
- 85 sites in Germany
- Volunteers
- 220 people
- Sponsor
- Goethe University
Acute Low Back Pain
The Palliative Effect of TENS-WAA on 'Capsaicin/Heat' Induced Acute Lower Back Pain: a Self-controlled Clinical Study
Acute lower back pain is a common condition that occurs in all age groups, and most people will experience acute lower back pain at least once in their lives.
- Trial name
- NCT06944665
- Testing
- Transcutaneous Electrical Nerve Stimulation based on Wrist-Ankle Acupuncture theory
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xiaonan Huang
Critical Illness, Acute Kidney Injury
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).
- Trial name
- KETZEREI (NCT06021288)
- Testing
- Effluent dose of CRRT
- Where
- 2 sites in Germany
- Volunteers
- 165 people
- Sponsor
- Universität Münster
Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients
This clinical trial aims to investigate whether the low treatment intensity (12 mL/kg/hr, low-dose hemodialysis/filtration) or the medium treatment intensity (25 mL/kg/hr, standard-dose hemodialysis/filtration) is more effective…
- Trial name
- LIMIT (NCT06014801)
- Testing
- Dialysate fluid, Filtration replacement fluid
- Where
- 9 sites in Japan
- Volunteers
- 400 people
- Sponsor
- Jikei University School of Medicine
Acute Decompensated Heart Failure, Acute Myocardial Infarction
Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations
Health literacy is the ability to access, understand, evaluate and apply information in order to communicate with health professionals and understand health instructions but also, promote, maintain and improve health throughout…
- Trial name
- ILIADE (NCT03951467)
- Testing
- Interventional educational toolkit specific to low Health Literacy patients, designed with patients and health professionals.
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Chronic Low-back Pain, Back Disorder
Movement Performance in Persons With Chronic Back Pain
The goal of this laboratory-based cross-over randomized controlled study is to study the immediate effects Spinal manipulative therapy (SMT) and exercise therapy (ET) compared to open-label placebo (OLP) on movement performance…
- Trial name
- NCT06891625
- Testing
- SMT, ET, OLP
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Acute Kidney Injury
Comparison of RCA and RACD in Extra-renal Purification by SLED
One of the main RRT issues is anticoagulation of the ECC, because blood contact with biomaterials causes bio-incompatibility reactions, including activation of the coagulation cascade.
- Trial name
- ARDC-SLED (NCT04968587)
- Testing
- Sustained Low-Efficiency Dialysis
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Groupe Hospitalier Sud Ile-de-France
Resource-Limited Setting, Delphi Study
Consensus on Low-resource Setting Definition: An inteRnational Delphi sTudY (CLARITY-LRS)
The term "low-resource setting" (LRS) is widely used in global health and critical care, yet no universally accepted definition exists.
- Conditions
- Resource-Limited Setting, Delphi Study, Consensus, Critical Care
- Trial name
- CLARITY-LRS (NCT07826819)
- Where
- Bosnia and Herzegovina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Republic of Srpska
Postoperative Pain, Postoperative Acute Pain
Comparative Analysis of the Impact of Transversus Abdominis Plane Block on Post-Cesarean Pain Management Using Low Concentration Ropivacaine 0,2%
The goal of this clinical trial is to evaluate whether the addition of a Transversus Abdominis Plane (TAP) block improves postoperative outcomes in women undergoing cesarean section.
- Trial name
- NCT07604376
- Testing
- Postoperative analgesia using TAP block, Ropivacaine 0,2%, volume: 0,4 ml/kg per side, Postoperative pain management using "traditional" analgesia iv regime
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Matild Keresztes
Leukemia, Myeloid, Acute
Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia (AML) Following Initial Treatment
ERASE is part of the MyeloMATCH initiative, Young Adult Basket and is a Tier 2 study. The study is comparing the use of Cytarabine to Cytarabine and Venetoclax, Daunorubicin/Cytarabine Liposome and Venetoclax, and Azacitidine and…
- Trial name
- ERASE (NCT05628623)
- Testing
- Cytarabine, Venetoclax, CPX-351
- Volunteers
- 184 people
- Sponsor
- Eastern Cooperative Oncology Group
Radiculopathy, Lumbosacral Region, Back Pain With Radiation
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by…
- Conditions
- Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
- Trial name
- NCT05721027
- Testing
- Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
Acute Pulmonary Embolism
Percutaneous Mechanical Thrombectomy With or Without Low-Dose Catheter-Directed Thrombolysis in Acute Intermediate-High Risk Pulmonary Embolism
Acute pulmonary embolism (PE) is the third most common cardiovascular cause of death. In patients with intermediate-high risk acute PE, percutaneous mechanical thrombectomy (PMT) using large-bore catheters achieves rapid…
- Trial name
- PMT-LDCDT-PE (NCT07865572)
- Testing
- PMT alone (percutaneous mechanical thrombectomy only), PMT plus low-dose catheter-directed thrombolysis (PMT+LDCDT)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Qiu Jipeng
Stroke Acute
Virtual Reality Rehabilitation for Stroke Patients in the Hospital and at Home.
The goal of this clinical trial is to test whether a low-cost virtual reality (VR) motor rehabilitation platform can improve motor recovery in people recovering from a first-time ischemic stroke both in the hospital and at home.
- Trial name
- NCT06864741
- Testing
- Virtual reality guided motor rehabilitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Acute Myeloid Leukemia
Azacitidine in Combination With Low Dose Intensity Venetoclax in Patients With AML Incl. Explorative AML Profiling
Multi-center phase II study of standard azacytidine treatment (AZA; D1-D7, 75mg/m2 qd) in combination with a short duration of "low-dose" venetoclax treatment (LD-VEN; D1-D14 before CR and D1-D7 after CR, 400mg qd) per 28 days…
- Trial name
- LD-VenEx (NCT05431257)
- Testing
- Venetoclax
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia
Tagraxofusp and Low-Intensity Chemotherapy for CD123-Positive Relapsed or Refractory AML
To determine the efficacy of the combination of tagraxofusp, cladribine, and cytarabine.
- Trial name
- NCT06561152
- Testing
- Tagraxofusp, Cladribine (CLAD), Cytarabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Acute Lymphoblastic Leukemia
CAV Regimen for R/R Ph- B-ALL
This study aims to investigate the efficacy and safety of cladribine, venetoclax combined with cytarabine and venetoclax (CAV regimen) for relapsed/refractory (R/R) Philadelphia Chromosome-negative (Ph-) B-cell acute…
- Trial name
- NCT05657652
- Testing
- cladribine, cytarabine,venetoclax
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Atrial Fibrillation (AF), Stroke
Comparative Evaluation of the Efficacy and Safety of High-Power Short-Duration Radiofrequency Ablation and Standard Low-Power Ablation in Catheter Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and represents one of the leading causes of cardiovascular morbidity and mortality.
- Conditions
- Atrial Fibrillation (AF), Stroke, Acute Cerebrovascular Accident, Atrial Fibrillation Recurrent
- Trial name
- NCT07728539
- Testing
- Technique of radiofrequency ablation using very high-power short-duration ablation parameters, Technique of radiofrequency ablation using low-power settings
- Where
- Russia
- Volunteers
- 196 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
CAYA Cancer Retrospective Cohort Study
Despite advances in cancer treatment, significant disparities in outcomes persist between high-income countries (HICs) and low-and middle-income countries (LMICs).
- Conditions
- Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Young Adult Cancer, Adolescent Cancer
- Trial name
- NCT07246213
- Testing
- Retrospective Medical Record Review
- Where
- 7 sites in Armenia, Egypt and 4 more
- Volunteers
- 18,000 people
- Sponsor
- Resonance, Inc.