Clinical trials: Low-grade Inflammation
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Phenylketonuria
Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria
Patient suffering from phenylketonuria have chronic hyperphenylalaninemia. Hyperphenylalaninemia is known to be toxic to central nervous system and cardiovascular system in particular through oxydative stress.
- Trial name
- INGRAPH (NCT04879277)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Milk Intolerance
Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyzed A1 Milk
The aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from…
- Trial name
- NCT05305391
- Testing
- Dietary intervention
- Where
- Finland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Turku
Metabolic Disease, Obesity, Infant
Metabotyping of Overweight and Obese Children
Today's children are increasingly facing metabolic-related health issues, among which the worldwide prevalence of overweight and obesity is rising at an alarming pace.
- Trial name
- RecSAMP (NCT04632511)
- Testing
- MetaSAMP
- Where
- 10 sites in Belgium
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University Ghent
Poly Cystic Ovarian Syndrome, Polycystic Ovary Syndrome (PCOS)
Biomechanical Changes in Females with Poly Cystic Ovarian Syndrome
Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disorder that causes an inversion of the normal luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio.
- Trial name
- NCT06673901
- Testing
- Measurments
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiometabolic Risk Factors, Inflammation
FILIP: Fat Intake, Inflammation and LIPids
Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process.
- Conditions
- Cardiometabolic Risk Factors, Inflammation, Microbiota
- Trial name
- FILIP (NCT06640036)
- Testing
- Rapeseed oil, Butter, Coconut oil
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Low-grade Chronic Inflammation, Intestinal Permeability
Diet and Systemic Inflammation
People with chronic low-grade inflammation have a higher risk for certain diseases such as cardiovascular disease or type 2 diabetes.
- Conditions
- Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease
- Trial name
- DASI (NCT01424306)
- Testing
- Fructose-sweetened beverages, Glucose-sweetened beverages, High-fructose corn syrup-sweetened beverages
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Insulin Sensitivity
The Potential of Carnosine Supplementation in Reducing the Cardiometabolic Risk
The aim of this study is to determine whether carnosine supplementation in overweight/obese individuals can improve insulin secretion and/or insulin resistance by decreasing sub clinical inflammation.
- Trial name
- NCT02686996
- Testing
- carnosine
- Where
- Australia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Monash University
Overweight (BMI > 25)
Anti-Inflammatory Effects of Pecan Nut Oil Supplementation in Adults With Overweight: A Randomized Controlled Parallel-Group Clinical Trial
The goal of this clinical trial is to evaluate whether daily supplementation with cold-pressed pecan nut oil can reduce inflammation in adults with overweight.
- Trial name
- NCT07497555
- Testing
- Pecan nut oil supplementation
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Psychology, Social, Inflammation
Body and Social Behavior
This randomized, double-blind, placebo-controlled study of the influenza vaccine will shed important light on how the immune system responds to different positive and negative social experiences.
- Conditions
- Psychology, Social, Inflammation, Defeat, Social, Interaction, Social
- Trial name
- BSB (NCT05654441)
- Testing
- Influenza vaccine
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Inflammaging, Sarcopenia
Inflammaging and Muscle Protein Metabolism
The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments.
- Trial name
- NCT03308747
- Testing
- Instantized Whey Protein Isolate
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Metabolic Syndrome, Obesity
Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue
This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Sensitivity
- Trial name
- NCT00774488
- Testing
- Glucose dependent insulinotropic polypeptide (GIP)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Aged, Healthy
Low Grade Inflammation, Gut Microbiota and Barrier Function in Elderly Humans
Cardiovascular diseases (CVD) are the main cause of death in the European Union. A large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks…
- Trial name
- NCT01218165
- Testing
- Probiotic drink, Control Group
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation
Fungal Fiber for Gut Health
This study compares effects of plant based fiber vs fungi based fiber on clinical outcomes related to gut function (immunity, emotions, stress) and explores the role of gut microbiome structure and function on individual…
- Conditions
- Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation, Stress, Gut Health
- Trial name
- FUN4GUT (NCT06404749)
- Testing
- fungal fiber, inulin
- Where
- Argentina
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Future Biome SA
Metabolic Syndrome, Impaired Glucose Tolerance
The Health Effect of Diet Rich in Nordic Berries
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures.
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Low-grade Inflammation, Dyslipidemia
- Trial name
- Berry (NCT01414647)
- Testing
- 300 g of strawberry, raspberry and cloudberry, 400 g of bilberry, Control diet
- Where
- Finland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Obesity, Chronic Inflammation
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)
Omega-3 fatty acids, especially EPA and DHA have long been acknowledged for their capacity to counteract inflammatory responses in the human body.
- Trial name
- EPICO (NCT05068557)
- Testing
- Dietary plan along with fish oil capsules (3 capsules daily. Containing EPA+DHA: 1.8 g)., Dietary plan along with chia/linseed oil capsules (3 capsules daily. Containing ALA 1.6 g).
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Keto Diet, Aerobic Exercise
Comparative Effects of Aerobic Exercise and Keto Diet on Obesity-Related Biomarkers in Obese Women With High (WHR)
the aim of this study is to compare between aerobic exercise and keto diet in their effect on obesity related biomarkers (testosterone, TNF alpha, IL6, HMW, BMI, WHR) in 120 obese women with high WHR.
- Conditions
- Keto Diet, Aerobic Exercise, Obesity (Disorder)
- Trial name
- NCT07834099
- Testing
- Keto diet, Aerobic exercise, Aerobic exercise + keto diet
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Metabolic Diseases
Fibrosis a New Pathological Actor in Adipose Tissue
Adipose tissue (AT) has specific alterations in obesity in particular increased fibrosis amount compared to lean subjects. Fibrosis amount measured by immunohistochemistry on adipose biopsies appears to to predict weight loss…
- Conditions
- Obesity, Metabolic Diseases, Fibrosis, Body Weight
- Trial name
- fibrota (NCT01655017)
- Testing
- biopsy
- Where
- 2 sites in France
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes, Inflammation
Low Grade Inflammation in Type 1 Diabetes Children
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.
- Trial name
- Coccinelle (NCT01099956)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Glucose Regulation, Low-grade Inflammation
Effect of Milk Ingredients on Glucose Regulation and Inflammation
Background: Recent advances in science have established a fundamental role for low grade chronic inflammation in mediating all stages of most of the non-communicable diseases associated with ageing.
- Trial name
- NCT02011672
- Testing
- nutrient-enriched milk, regular milk
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research