Clinical trials: Lower Extremity Function
Anterior Cruciate Ligament Injuries
Muscle Architecture and Anterior Cruciate Ligament
The aim of this study is to examine the effects of plyometric training on biceps femoris longus (BFl) and vastus lateralis (VL) muscle architecture in individuals with anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT04690127
- Testing
- Plyometric Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing…
- Trial name
- TENS (NCT06541015)
- Testing
- InTENSity 10 TENS Stimulator
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot Ulcer, Wound Healing
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery
This observational prospective cohort study will evaluate whether routine blood tests are associated with the functional quality of calcaneal bone marrow aspirate mesenchymal stem cells in adults undergoing clinically indicated…
- Conditions
- Diabetic Foot Ulcer, Wound Healing, Foot Ulcer Due to Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2
- Trial name
- IQF-BMA (NCT07802106)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Sao Francisco
Joint Disease
Gait and Functional Outcomes Study Following Total Knee Arthroplasty With Medial-pivot or Posterior-stabilized Implants
MicroPort Orthopedics (MPO) is conducting this study to build upon the results of a previous study which showed the Medial Pivot (MP) system required lower quadriceps activation than subjects implanted with a Posterior stabilized…
- Trial name
- GOLD (NCT02589197)
- Testing
- Group 1 (Medial-Pivot), Group 2 (Posterior-Stabilized)
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- MicroPort Orthopedics Inc.
Phantom Limb Pain
Phantom Limb Pain Triggered by Micturition
Phantom Limb Pain ( PLP) is pain that is perceived and referred to a region of the body that is no longer present. in most patients, severity and frequency of phantom pain attacks gradually decrease over several weeks to 2 years…
- Trial name
- NCT03855930
- Testing
- functional MRI
- Where
- 2 sites in Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Functional Ankle Instability
Effects of Taping on Performance in Adolescent Volleyball Players With Patient-Reported Ankle Instability
The purpose of this study is to investigate the effects of different types of taping application to functional performancein adolescent volleyball players with functional ankle instability.
- Trial name
- NCT07165613
- Testing
- Kinesiotape, Dynamic tape
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Anterior Cruciate Ligament Injuries
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee…
- Trial name
- NCT07243860
- Testing
- Neuromuscular Training, Conventional Rehabilitation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Total Knee Arthroplasty
Effectiveness of a Community-based Multi-modal Tai Chi Rehabilitation Program for Patients After Total Knee Arthroplasty
The rate of falls in patients after total knee arthroplasty (TKA) is high and related to lower limb muscle weakness and poor balance control.
- Trial name
- NCT03565380
- Testing
- 12-week community-based multi-model Tai Chi rehabilitation program, Usual post-operative care, Untreated asymptomatic controls
- Where
- Hong Kong
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
ACL - Anterior Cruciate Ligament Rupture, ACL Injury
Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Reconstruction:
The proposed study will establish novel relationships between intra-articular mesenchymal stem cell (MSC) recruitment, synovial inflammation, biomarkers of cartilage degeneration and joint inflammation, clinical patient factors…
- Conditions
- ACL - Anterior Cruciate Ligament Rupture, ACL Injury, Healthy
- Trial name
- NCT03497780
- Testing
- Anterior cruciate ligament reconstruction
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Ankle Sprains
Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI
The investigator's purpose is to compare the effects of talocrural joint mobilization with movement versus thrust mobilization on functional performance in subjects reporting chronic ankle instability (CAI).
- Trial name
- NCT03918473
- Testing
- Mobilization with Movement, Thrust Mobilization
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Bronchiectasis
Balance, Cognıtıve Skılls, Hand Functıons and Qualıty of Lıfe Among Patients with Bronchiectasis and Healthy Peers
The aim of this study is to comparatively evaluate the parameters of balance, cognitive skills, hand grip strength, reaction time, quality of life and respiratory functions in elderly and healthy peers individuals.
- Trial name
- NCT06606665
- Testing
- Cognitive skills test, Reaction time test, Quality of life assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlas University
Hearing Impaired Children
Effects of Pilates and Balance Proprioception Exercises on Hearing Impairment
Static balance is the ability to hold the body in a specific position and posture, while dynamic balance is the ability to maintain balance while moving.
- Trial name
- NCT06198049
- Testing
- Pilates Training, Balance Proprioception Exercises
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Postural, Defect
TENS and Taping for Older People
Aim: To examine the acute effects of transcutaneous electrical nerve stimulation (TENS) and Kinesio Taping (KT) on lower limb joint proprioception, static standing balance, limits of stability and functional balance performance…
- Trial name
- NCT05596110
- Testing
- TENS and KT
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cognitive Functioning of Healthy Individuals, Balance
Task-Specific Training vs. Yoga (With and Without Perturbation) for Balance and Leg Strength in Older Adults
This experimental study is designed to observe the effectiveness of task-specific training vs yoga with and without perturbation on reactive balance and leg strength in older individuals in Islamabad/Rawalpindi, Pakistan.
- Conditions
- Cognitive Functioning of Healthy Individuals, Balance, Strength, Muscle, Quality of Life (QOL)
- Trial name
- NCT06875388
- Testing
- Task specific Training, Specific Yoga Poses, Tasl specific Training with perturbation
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Taekwondo Roundhouse Kick Biomechanics
Lower Limb Biomechanics of the Roundhouse Kick in Elite and Youth Taekwondo Athletes Using FPCA
This study aims to understand how the lower limbs (hip, knee, and ankle) function during a taekwondo roundhouse kick. Elite and youth taekwondo athletes will be compared to identify movement and muscle-activation patterns related…
- Trial name
- NCT07307378
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Neuromuscular Control, Functional Training
Comparison of Lower Limb COP and Muscle Activation During Single-Leg Deadlift Using Elastic and Inelastic Barbells
This study aims to investigate the effects of barbell type (elastic vs. inelastic) and lifting speed on lower limb balance and muscle activation during the Single-Leg Deadlift (SLDL) exercise.
- Conditions
- Neuromuscular Control, Functional Training, Lower Limb Stability
- Trial name
- NCT07061314
- Testing
- Elastic Barbell, Inelastic Barbell
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Busan University of Foreign Studies
Osteoarthritis, Knee, Arthropathy of Knee
Late-initiated Blood Flow Restricted Rehabilitation Exercises After Total Knee Replacement
This trial will investigate the effectiveness of applying low-load blood flow restricted exercise 12 months after receiving a total knee replacement to achieve a functional capacity-level similar to healthy peers.
- Trial name
- EXKnee2 (NCT05770934)
- Testing
- Blood flow restricted low-load resistance exercise
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Endothelial Dysfunction
Artery Function Responses to Heat Therapy and Exercise Training
This study will explore the effects of 8 weeks of local leg heat therapy, exercise training, or both on measures of vascular function, cardiorespiratory fitness, and muscle strength in young, healthy individuals.
- Trial name
- NCT04588103
- Testing
- Heat therapy, Exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Shin Splint
Effects of Autogenic Inhibition and Reciprocal Inhibition in Amateur Football Players With Shin Splints.
This randomized controlled trial aims to compare the effectiveness of Autogenic Inhibition and Reciprocal Inhibition in treating shin splints among amateur footballers aged 18-30 from SA Gardens Football Club, Lahore.
- Trial name
- NCT06501430
- Testing
- Heating Therapy, Manual Soft tissue Release
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University