Clinical trials: Lower Urinary Tract Disorder
Stress Urinary Incontinence, Urgency Urinary Incontinence
A Study to Estimate the Efficacy and Safety of Solifenacin in Female With Stress Urinary Incontinence and Urgency Urinary Incontinence
This study is to investigate the effects of solifenacin on urgency urinary incontinence symptoms and incontinence quality-of-life (I-QoL) in female patients with clinically significant stress urinary incontinence accompanied by…
- Trial name
- NCT01505439
- Testing
- solifenacin
- Where
- 6 sites in South Korea
- Volunteers
- 311 people
- Sponsor
- Jeong Gu Lee
Overactive Bladder, Deprescribing
Deprescribing dRrugs for Overactive Bladder in General Practice (DROP)
The objective is to understand and evaluate the effectiveness of a deprescribing intervention in primary care, specifically targeting medications for overactive bladder in individuals aged 65 or older.
- Conditions
- Overactive Bladder, Deprescribing, PIMS
- Trial name
- DROP (NCT06110975)
- Testing
- deprescribing-intervention
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Anne Estrup Olesen
Nocturia
Efficacy Study of VA106483 in Males With Nocturia.
To investigate the effect of VA106483 on nocturia related clinical outcomes compared to placebo.
- Trial name
- NCT01038843
- Testing
- VA106483
- Where
- 19 sites in United States
- Volunteers
- 152 people
- Sponsor
- Vantia Ltd
Stress Urinary Incontinence, Surgery--Complications
Transobturator Urethral Sling Placement With an Autologous Rectus Facia
The investigators aimed to evaluate outcomes of transobturator urethral sling placement using autologous rectus fascia for female stress urinary incontinence at perioperatively and at 2-year follow-up.
- Trial name
- NCT03949348
- Testing
- Mid-urethral sling placement using autologous rectus fascia, Mid-urethral sling placement using synthetic mesh
- Volunteers
- 35 people
- Sponsor
- Ankara Training and Research Hospital
Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence
The Effect Of Fluconazole On Pharmacokinetics Of Fesoterodine In Healthy Subjects
This study is designed to estimate the effect of fluconazole (200 mg BID for 2 days), a moderate CYP3A4 inhibitor on the pharmacokinetics of a single 8 mg oral dose of fesoterodine in healthy adult subjects.
- Trial name
- NCT00911235
- Testing
- Fesoterodine, fesoterodine plus fluconazole
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Urge Urinary Incontinence
A Comparison of Electrical Pudendal Nerve Stimulation and Transvaginal Electrical Stimulation for Urge Incontinence
The purpose of this study is to determine whether electrical pudendal nerve stimulation is more effective than transvaginal electrical stimulation in treating urge urinary incontinence (UUI).
- Trial name
- NCT02311634
- Testing
- Electrical pudendal nerve stimulation, Transvaginal ES
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Urinary Incontinence
Muscle Fiber Fragment Treatment for Urinary Incontinence
This study is designed to evaluate the safety of autologous muscle fiber fragments for the treatment of urinary incontinence due to incompetent outlet (bladder neck/urethra).
- Trial name
- NCT01953263
- Testing
- Autologous Muscle Fiber Fragments
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University
Overactive Bladder
Use of Percutaneous Tibial Nerve Stimulation With Solifenacin or Placebo to Treat Refractory Overactive Bladder
The null hypothesis for this study is that the combination of solifenacin and Percutaneous Tibial Nerve Stimulation (PTNS) is not different from PTNS alone.
- Trial name
- NCT01764893
- Testing
- PTNS plus solifenacin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Bay State Clinical Trials, Inc.
Urinary Incontinence, Diabetes
Urinary Incontinence and Endocrine Factors. A Part of Lolland-Falster Health Study (LOFUS).
Previous studies have shown an increase in the prevalence of urgency and urgency incontinence in women with diabetes. Regarding the condition urinary stress incontinence, the literature is diverted.
- Conditions
- Urinary Incontinence, Diabetes, Thyroid Diseases
- Trial name
- EFUI (NCT04279184)
- Where
- Denmark
- Volunteers
- 6,000 people
- Sponsor
- Nykøbing Falster County Hospital
Urology, Urinary Bladder, Overactive
Ambulatory Long Length URodynamics Evaluation
A prospective, open-label, single arm interventional trial evaluating the safety and performance of the in-clinic and extended monitoring of the lower urinary tract using the Glean Urodynamics System.
- Conditions
- Urology, Urinary Bladder, Overactive, Benign Prostatic Hyperplasia, Urodynamics
- Trial name
- ALLURE (NCT07425015)
- Testing
- Glean Urodynamics System
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Bright Uro
Urinary Bladder, Overactive
Study to Assess the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder
The study is intended to test efficacy, safety and tolerability of two doses of Mirabegron against placebo and compare the efficacy and safety with active comparator in patients with symptoms of overactive bladder.
- Trial name
- SCORPIO (NCT00689104)
- Testing
- Mirabegron, Tolterodine
- Where
- 218 sites in Australia, Austria and 28 more
- Volunteers
- 2,336 people
- Sponsor
- Astellas Pharma Inc
Stress Urinary Incontinence (SUI), Female Stress Urinary Incontinence
Sling Insertion Angle and Outcomes in Single-Incision Midurethral Sling Surgery
This study aims to evaluate the effect of sling insertion angle on surgical outcomes and quality of life in women with stress urinary incontinence (SUI) undergoing single-incision midurethral sling surgery.
- Trial name
- SUI-SLING (NCT07530484)
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Urinary Incontinence, Platelet Rich Plasma
Strategy for Managing Urinary Incontinence With PRP
Urinary incontinence is a public health issue; in France, approximately 3 million women are affected. Current treatment options-particularly surgical procedures involving the use of prosthetic materials-are being called into…
- Trial name
- PRPIU (NCT07832487)
- Testing
- Plasma rich platelet injection, Blood test, cytobacteriological examination of urine
- Where
- France
- Volunteers
- 41 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Stress, Urinary
Laser Acupuncture and Pelvic Floor Training on Stress Urinary Incontinence Postmenopausal
This study will be directed to determine the effectiveness of laser acupuncture(LA) and pelvic floor training (PFT) on stress urinary incontinence (SUI) in obese postmenopausal women.
- Conditions
- Stress, Urinary, Incontinence
- Trial name
- NCT04959084
- Testing
- Laser acupuncture therapy and pelvic floor training
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Urinary Incontinence (UI)
Behavior Enhances Drug Reduction of Incontinence (BE-DRI)
The primary aim of this study is to test if the addition of behavioral treatment to drug therapy for the treatment of urge incontinence will increase the number of patients who can discontinue drug therapy and sustain a…
- Trial name
- BE-DRI (NCT00090584)
- Testing
- Tolterodine, Behavioral training
- Where
- 9 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Overactive Bladder, Urinary Tract Infection
Urinary Cytokines in Patients With Overactive Bladder (OAB)
Overactive bladder (OAB) is a widespread condition characterized by urgency, urge incontinence, nocturia and excessive urinary frequency, affecting millions of people worldwide.
- Trial name
- NCT00868621
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Urinary Incontinence,Stress
A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
The GZPS master protocol will support two independent studies, J2A-MC-GZS1 and J2A-MC-GZS2. Each study will see how well and safely orforglipron works in adult female participants with stress urinary incontinence (SUI) who have…
- Trial name
- RESTRAIN-SUI (NCT07202884)
- Testing
- Orforglipron
- Where
- 136 sites in United States, Canada and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Eli Lilly and Company
Prostate Cancer, Urinary Incontinence
Effect of Beta-alanine and Pelvic Floor Muscle Training on Urinary Incontinence After Radical Prostatectomy (BELA)
The purpose of this study is to evaluate the effectiveness of beta-alanine in combination with pelvic floor muscle training (PFMT) compared to PFMT plus placebo in men undergoing radical prostatectomy.
- Conditions
- Prostate Cancer, Urinary Incontinence, Beta-Alanine, Pelvic Floor Muscle Training
- Trial name
- BELA (NCT04862533)
- Testing
- Beta-Alanine, Pelvic floor muscle training (PFMT)
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Olomouc
Stress Urinary Incontinence
Serial Changes in Micturition Symptoms, Urine Flow and Bladder Voiding Efficiency Following Transobturator Tape Surgery
The aim of this study was to identify the serial changes in lower urinary tract symptoms (LUTS), urine flow and bladder voiding efficiency after transobturator tape (TOT) surgery for treatment of female stress urinary…
- Trial name
- NCT02242422
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- DongGuk University
Urinary Incontinence (UI)
Comparison of Home Versus Clinic Kegel Rehabilitation in Women With Urinary Incontinence in the Tabuk Region
Urinary incontinence is a common condition among women that significantly affects physical health, emotional well-being, social participation, and overall quality of life.
- Trial name
- Incontinence (NCT07795931)
- Testing
- Home -Based Kegel Trainer Exercises (Kegel Trainer Application) will be used by the participants at home for training the pelvic floor muscles over 9 levels., Clinic-Based Rehabilitation Program will consist of physiotherapist supervised pelvic floor strengthening exercises for the participant , 2 times per week for 3 months
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- University of Tabuk