Clinical trials: Lumbar Back Pain
Low Back Pain
Efficacy of the Quell Wearable Device for Chronic Low Back Pain
This is a 1-year trial designed to gather information about the use of the Quell for persons with chronic musculoskeletal low back pain.
- Trial name
- NCT02944513
- Testing
- Quell
- Volunteers
- 68 people
- Sponsor
- Brigham and Women's Hospital
Low Back Pain
Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients
The long-term goal for this study is to understand the physiological mechanisms of various forms of spinal manipulation in order to refine and improve this therapy for appropriately selected patients.
- Trial name
- D2P3 (NCT00830596)
- Testing
- HVLA-SM, LVVA-SM
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Palmer College of Chiropractic
Lower Back Pain
Placebo-controlled Trial of Transdiscal Radiofrequency Annuloplasty
Each patient was assigned to one of the two groups: IDB or Sham. On the day of the procedure, an IV was inserted in pre-procedural area and patient transported to the procedure room.
- Trial name
- NCT00750191
- Testing
- The Transdiscal Radiofrequency Annuloplasty
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Baylis Medical Company
Radicular Low Back Pain
A Trial of Corticosteroids for Low Back Pain
Low back pain is a common symptom that functionally disables many people. When the low back pain is accompanied by pain that shoots down the leg, it is felt to be caused by a herniated disc.
- Trial name
- NCT00290589
- Testing
- Intramuscular methylprednisolone acetate
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Montefiore Medical Center
Acute Low Back Pain
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Low back pain causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In a general low back pain (LBP) population, prognosis is poor.
- Trial name
- NCT01587274
- Testing
- Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Montefiore Medical Center
Low Back Pain, Back Pain
Access to a Sit-stand Computer Workstation and Back Pain
The purpose of the study is to evaluate the changes in back pain from access to a sit-stand workstation. Other muscle and joint pain and/or discomfort will also be evaluated.
- Trial name
- NCT02146482
- Testing
- Sit-stand computer workstation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Stanford University
Chronic Pain, Chronic Low Back Pain
Pain Research: Innovative Strategies With Marijuana
This study tests the effects of cannabinoid levels in blood on pain relief, inflammation, and cognitive dysfunction in chronic pain patients who choose to use edible cannabis.
- Conditions
- Chronic Pain, Chronic Low Back Pain, Cannabis Use
- Trial name
- PRISM (NCT03522324)
- Testing
- Cannabis Edible
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of Colorado, Boulder
Degenerative Disc Disease
Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain
This is a prospective, multicenter, randomized, double-blind, placebo-controlled Phase 3 study designed to evaluate the safety and efficacy of Mesoblast's rexlemestrocel-L alone or combined with hyaluronic acid (HA) in…
- Trial name
- MSB-DR003 (NCT02412735)
- Testing
- Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture
- Where
- 48 sites in United States, Australia
- Volunteers
- 404 people
- Sponsor
- Mesoblast, Ltd.
Chronic Low Back Pain, Sacroiliitis
Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint
This prospective study will be quantitatively analyzing the effectiveness of platelet-rich-plasma (PRP) injections into the sacroiliac (SI) joint in relieving sacroiliitis and low back pain originating from the SI joint.
- Conditions
- Chronic Low Back Pain, Sacroiliitis, Sacroiliac; Backache, Platelet Rich Plasma
- Trial name
- NCT03122119
- Testing
- Platelet Rich Plasma Joint Injection
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Star Spine and Sport
Chronic Low-back Pain
The BEST Trial: Biomarkers for Evaluating Spine Treatments
The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)-sponsored clinical trial being conducted through the NIH Helping to End Addiction…
- Trial name
- BEST (NCT05396014)
- Testing
- Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM)
- Where
- 12 sites in United States
- Volunteers
- 1,014 people
- Sponsor
- University of North Carolina, Chapel Hill
Back Pain With Radiation
Evaluation of the Percutaneous SCS Trial Using the DSSEP Collision Testing
This study is to objectively evaluate the success of a spinal cord stimulator (SCS) trial using testing (DSSEP) to determine if the paresthesia (tingling sensation) or pain reduction achieved correlates with the degree of…
- Trial name
- NCT02614079
- Testing
- DSSEP
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Toledo Health Science Campus
Low Back Pain
Long Term Safety Study of Tanezumab in Chronic Low Back Pain
The purpose of this study is to investigate the safety and efficacy of tanezumab for chronic low back pain. Patients who were randomized and treated with study medication in a previous chronic low back pain "parent" study will be…
- Trial name
- NCT00924664
- Testing
- Tanezumab 20 mg, Tanezumab 10 mg
- Where
- 149 sites in United States
- Volunteers
- 849 people
- Sponsor
- Pfizer
Low Back Pain
Optimization of Spinal Manipulative Therapy Protocols
Research on spinal manipulative therapy for individuals with low back pain has been hampered by a lack of understanding of which of the physiologic effects produced by spinal manipulation are related to clinical benefit, and how…
- Trial name
- NCT02868034
- Testing
- SMT, Mobilizing Exercises, Activation Exercises
- Where
- 2 sites in United States, Canada
- Volunteers
- 273 people
- Sponsor
- University of Utah
Lumbar Degenerative Disc Disease
TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study
The purpose of this investigation is to evaluate the safety and effectiveness of the TRIUMPH® Lumbar Artificial Disc for the treatment of patients who are suffering from Degenerative Disc Disease (DDD) at one level from L1 to S1.
- Trial name
- NCT01198470
- Testing
- TRIUMPH® Lumbar Artificial Disc
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Globus Medical Inc
Low Back Pain
The Effect of Lumbar Stabilization Exercise and Gait Training on Lower Back Muscles- Electromyographic(EMG) Analysis
The purpose of this study is to determine the effective exercise protocol in chronic low back pain patients.
- Trial name
- EMG (NCT02938169)
- Testing
- exercise
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Chronic Lower Back Pain, Chronic Pain
Buprenorphine (CAM2038) in Subjects With a Recent History of Moderate to Severe Chronic Low Back Pain
This is a Phase III, placebo-controlled, multicenter study with an enriched-enrollment withdrawal (EEW) design to evaluate the efficacy and safety of CAM2038 in opioid-experienced subjects with moderate to severe CLBP that…
- Trial name
- CAM2038 (NCT02946073)
- Testing
- buprenorphine
- Where
- 69 sites in United States
- Volunteers
- 1,053 people
- Sponsor
- Braeburn Pharmaceuticals
Low Back Pain
Study of Low Level Laser Therapy to Treat Low Back Pain
The purpose of this study is to determine whether the Erchonia® ML Scanner (MLS) is effective in the treatment of acute minor episodic chronic low back pain of musculoskeletal origin.
- Trial name
- NCT01835756
- Testing
- Erchonia MLS
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Erchonia Corporation
Low Back Pain, Chronic Pain
Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain
The purpose of this study is to determine whether a new opioid molecule, NKTR-181, is effective for the relief of moderate to severe chronic low back pain as compared to a placebo.
- Trial name
- SUMMIT-07 (NCT02362672)
- Testing
- NKTR-181 BID tablets
- Where
- 54 sites in United States
- Volunteers
- 1,189 people
- Sponsor
- Nektar Therapeutics
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Low Back Pain
Comparative Effectiveness of Early Physical Therapy Versus Usual Care for Low Back Pain
The primary purpose of this study is to compare the effectiveness of two management strategies for patients with a recent onset of low back pain (LBP).
- Trial name
- COMPETE (NCT01556581)
- Testing
- Usual Care (UC), Early Physical Therapy (PT)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Madigan Army Medical Center