Clinical trials: Lumbar Pain
Low Back Pain
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Naive Subjects
The purpose of this study is to determine if buprenorphine hydrochloride (HCl) buccal film is effective in treating opioid-naive subjects, with moderate to severe chronic low back pain (CLBP), who require continuous…
- Trial name
- NCT01633944
- Testing
- Buprenorphine
- Where
- 60 sites in United States
- Volunteers
- 752 people
- Sponsor
- BioDelivery Sciences International
Acute Low-back Pain, Muscle Spasm; Back Pain
Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm
This is a Phase III, longitudinal, multicenter, randomized, double-blind clinical trial. The aim of the study is to evaluate the efficacy and safety of a fixed-dose combination of etoricoxib and tizanidine compared to etoricoxib…
- Trial name
- NCT06863662
- Testing
- Etoricoxib + Tizanidine fixed dose, Etoricoxib fixed dose
- Where
- Mexico
- Volunteers
- 136 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Low Back Pain, Neck Pain
Electrical Impedance Myography of Neck and Low Back Pain
The purpose of this study is to assess neck and low back pain using Electrical Impedance Myography (EIM) in order to develop an algorithm to aid primary care providers (PCPs) in the diagnosis of neck/back pain.
- Trial name
- EIM (NCT02159677)
- Testing
- EIM Measurements
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Skulpt, Inc.
Postoperative Pain Management
Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries
Primary Objective: The primary objective of this study is to compare postsurgical opioid consumption through 72 hours postsurgery in patients receiving local infiltration analgesia (LIA) with EXPAREL and bupivacaine HCl (EXPAREL…
- Trial name
- FUSION (NCT03927911)
- Testing
- EXPAREL and Bupivacaine, Standard of Care
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Low Back Pain
Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain
The primary objective is to demonstrate the safety and tolerability of COV795 with up to 35 days use as evaluated by physical exam, vital signs, pulse oximetry, clinical laboratory tests, and other adverse events (AEs).
- Trial name
- NCT01451385
- Testing
- COV795
- Where
- 42 sites in United States
- Volunteers
- 376 people
- Sponsor
- Mallinckrodt
Chronic Low Back Pain, Lumbar Degenerative Disc Disease
Safety and Performance Study of the CAdiscTM-L Lumbar Spinal Disc Replacement Device For CE Marking
The purpose of this European Union (EU) study to evaluate the safety and performance of the CAdiscTM-L Lumbar Spinal Disc Replacement Device in the surgical replacement of the lumbar intervertebral discs (L3 to S1) for patients…
- Trial name
- DISCERN (NCT00949936)
- Testing
- CAdisc™-L (Total Disc Replacement)
- Where
- 4 sites in Belgium, Germany and 2 more
- Sponsor
- Ranier Technology Limited
Degenerative Disc Disease, Disc Degeneration
ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs
VIA Disc NP is an off-the-shelf minimally processed human nucleus pulposus tissue allograft intended to supplement degenerated intervertebral discs.
- Conditions
- Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain
- Trial name
- ASCEND (NCT06615505)
- Testing
- VIA Disc NP
- Where
- 5 sites in Australia
- Volunteers
- 121 people
- Sponsor
- VIVEX Biologics, Inc.
Chronic Low Back Pain
Comparison of Senza to Commercial Spinal Cord Stimulation for the Treatment of Chronic Pain
The purpose of this investigational study is to establish the safety and effectiveness of electrical stimulation delivered to the spinal cord in subjects with chronic, intractable pain of the trunk and/or limbs and will be a…
- Trial name
- SENZA-RCT (NCT01609972)
- Testing
- Spinal Cord Stimulator
- Volunteers
- 356 people
- Sponsor
- Nevro Corp
Pain
An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride plus acetaminophen (JNS013) in participants with chronic pain accompanied by osteoarthritis (a progressive and degenerative joint disease…
- Trial name
- NCT00736853
- Testing
- Tramadol Hydrochloride Plus Acetaminophen (Open-Label), Tramadol Hydrochloride Plus Acetaminophen (Double-Blind)
- Where
- 20 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Janssen Pharmaceutical K.K.
Low Back Pain
A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain
The main objective of the trial is to evaluate the efficacy of fasinumab compared to placebo as measured by the change from baseline in the average daily Low Back Pain Intensity (LBPI) Numerical Rating Scale (NRS).
- Trial name
- NCT02620020
- Testing
- Fasinumab
- Where
- 74 sites in United States, Canada and 5 more
- Volunteers
- 563 people
- Sponsor
- Regeneron Pharmaceuticals
Radiculopathy Lumbar
A Two-part Proof-of-Concept Study Assessing the Safety and Efficacy of LAT8881 in Lumbar Radicular Pain
The study consists of two parts. Part A will evaluate the safety and tolerability of intravenous LAT8881 in healthy volunteers using an ascending dose schedule.
- Trial name
- NCT05298306
- Testing
- LAT8881
- Where
- Australia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Lateral Pharma Pty Ltd
Acute Low-back Pain, Chronic Low-back Pain
Impact of DuoTherm Compared to TENS on Pain and Disability With Acute and Chronic Low Back Pain
Evaluate pain and disability change in Low Back Pain with DuoTherm Compared to Active Control
- Conditions
- Acute Low-back Pain, Chronic Low-back Pain, Pain, Intractable
- Trial name
- NCT04494698
- Testing
- Duotherm VibraCool Back Device, TENS 8-channel unit
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- MMJ Labs LLC
Low Back Pain
Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940
A Phase I, Multi-Centre, Randomised, Double-blind, Placebo-controlled Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940, Including an Interaction Study, After Administration of Oral Multiple Ascending…
- Trial name
- NCT00689780
- Testing
- AZD1940, Midazolam
- Where
- 3 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Sacroiliitis
Safety and Feasibility of the NeurolyserXR for Sacroiliac Joint Pain
Pilot study to evaluate the safety and the effectiveness of the Neurolyser XR as a treatment for sacroiliitis
- Trial name
- NCT05396495
- Testing
- NeurolyserXR
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- FUSMobile Inc.
Chronic Low Back Pain
PF-06372865 In Subjects With Chronic Low Back Pain
PF-06372865 In Subjects With Chronic Low Back Pain
- Trial name
- NCT02262754
- Testing
- PF-06372865, Naproxen
- Where
- 46 sites in United States
- Volunteers
- 302 people
- Sponsor
- Pfizer
Chronic Low Back Pain
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
The primary purpose of the study is to test the efficacy of 2 tablets (twice daily) of ABT-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain…
- Trial name
- NCT00763321
- Testing
- ABT-712
- Where
- 31 sites in United States
- Volunteers
- 287 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Facet Syndrome of Lumbar Spine
Double Arm Pivotal Study to Evaluate the Neurolyser XR for the Treatment of Chronic Low Back Pain
Double arm pivotal study to evaluate the Neurolyser XR as a non-invasive treatment of axial chronic low back pain
- Trial name
- NCT05154448
- Testing
- Non-Invasive Thermal Ablation of the Medial Branch Nerves (Neurolyser XR)
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- FUSMobile Inc.
Chronic Pain, Low Back Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking either WHO Step…
- Trial name
- NCT00983385
- Testing
- Tapentadol PR, Observation period
- Where
- 46 sites in Austria, Croatia and 7 more
- Volunteers
- 208 people
- Sponsor
- Grünenthal GmbH
Degenerative Disc Disease
Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain
The purpose of this study is to compare two doses of immunoselected, culture-expanded, nucleated, allogeneic adult MPCs when combined with hyaluronic acid to two control intradiscal injections in subjects with chronic low back…
- Trial name
- NCT01290367
- Testing
- Single Dose MPCs Injection, Single injection of saline solution, Single injection of hyaluronic acid
- Where
- 14 sites in United States, Australia
- Volunteers
- 100 people
- Sponsor
- Mesoblast, Ltd.
Pain, Low Back Pain
An Efficacy and Safety Study for Tapentadol Extended Release (JNS024ER) in Chronic Pain Participants
The purpose of this study is to evaluate the efficacy, safety and to explore the pharmacokinetics (how drugs are absorbed in the body, how they are distributed within the body and how they are removed from the body over time) of…
- Conditions
- Pain, Low Back Pain, Back Pain, Osteoarthritis, Knee
- Trial name
- NCT01124604
- Testing
- Tapentadol Hydrochloride
- Where
- 19 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Janssen Pharmaceutical K.K.