Clinical trials: Lung; Node, open to volunteers
Lung Adenocarcinoma
Lymph Node Pathologic Grading Strategy
The percentage of high-grade patterns in metastatic LNs (mLNs) that can predict poor outcomes has yet to be determined. Additionally, the potential implications of other histologic patterns in metastatic lymph nodes on patient…
- Trial name
- NCT06745830
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,998 people
- Sponsor
- Fudan University
Lung Cancer
Detection of Genetic Markers of Lung Cancer
The purpose of this research study is to determine the genetic changes and immunologic changes that are involved in the development and progression of bronchogenic lung cancer.
- Trial name
- NCT00280202
- Testing
- Biopsy of the major carinal area, Biopsy of abnormal & suspicious areas of the bronchial tree, Evaluation of the tumor for DNA mutations
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- University of Pittsburgh
NSCLC (Advanced Non-small Cell Lung Cancer), Post Surgical
Radiotherapy Plus Anti-PD-1 Versus Anti-PD-1 Alone in ypTanyN⁺M0 NSCLC
Patients with stage III non-small-cell lung cancer (NSCLC) who receive neoadjuvant chemoimmunotherapy may achieve good response in the primary tumor but still have residual nodal disease after surgery (ypTanyN⁺M0), which is…
- Trial name
- NCT07353476
- Testing
- radiotherapy, PD -1/PD-L1 monoclonal antibody
- Volunteers
- 38 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Lesions, Mediastinal and Hilar Lymph Node Enlargement
A Study of Contrast-enhanced EBUS in Lung Lesions and Intrathoracic Lymph Nodes
Exploring the Clinical Application Value of Contrast Enhancement Features in CE-EBUS Images for the Diagnosis of Pulmonary Lesions and Intrapulmonary Lymph Nodes
- Trial name
- NCT07060378
- Testing
- Contrast-enhanced endobronchial ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Lung; Node
Robotic Systems Evaluation for Peripheral Pulmonary Lesions (RISE Trial)
This is an investigator-initiated cluster randomized control trial. The primary objective is to compare the diagnostic yield of two Food and Drug Administration (FDA) cleared national robotic assisted bronchoscopy platforms - the…
- Trial name
- NCT07735611
- Testing
- RAB via the Monarch platform, RAB via the ION platform
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- Case Comprehensive Cancer Center
Lymph Node Dissection, Advanced Non-small Cell Lung Cancer (NSCLC)
Complications Associated With Lymphadenectomy (LAD) in Surgical Treatment of Non-small Cell Lung Cancer (NSCLC).
Systemic mediastinal lymph node dissection is a standard step in radical surgery for advanced non-small cell lung cancer (NSCLC).
- Trial name
- LNDNSCLC-RUS (NCT07401498)
- Testing
- Systematic mediastinal nodal dissection (SND), Lobe-Specific Lymph Node Dissection (L-SND)
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Regional Clinical Oncology Dispensary
Non Small Cell Lung Cancer
Evaluation of Lymph Node Analysis Using One Step Nucleic Acid Amplification (OSNA) in Patients With Lung Cancer Who Underwent Robotic Lung Resection, Comparison With Traditional Methods
This prospective study aims to evaluate the effectiveness of the One-Step Nucleic Acid Amplification (OSNA) technique for detecting micrometastases in lymph nodes of patients with clinical stage I-II non-small cell lung cancer…
- Trial name
- LALC (NCT07301983)
- Testing
- lymph node analysis using the OSNA assay
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Lung Cancer, Lymph Node Metastasis
Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist.
- Conditions
- Lung Cancer, Lymph Node Metastasis, Pathologic Processes
- Trial name
- NCT06252129
- Testing
- Subjects undergoing a lung specimen lymph node dissection, Control group
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lung Neoplasms, Pulmonary Neoplasms
Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy
In this feasibility study, bronchoscopy will be combined with fluorescence molecular imaging using the near-infrared fluorescence (NIRF) tracer bevacizumab-800CW for assessment of pulmonary lesions and/or lymph nodes considered…
- Conditions
- Lung Neoplasms, Pulmonary Neoplasms, Lymph Node Involvement, Pulmonary Nodule
- Trial name
- DEFLECT I (NCT06809946)
- Testing
- injection with 15 mg bevacizumab-800CW before bronchoscopy, injection with 25 mg bevacizumab-800CW before bronchoscopy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Lung Adenocarcinoma, Stage I
Improving the Intraoperative Diagnosis Accuracy of Invasiveness for Small-sized Lung Adenocarcinoma
The goal of this observational study is to improve the intraoperative diagnosis accuracy of invasiveness for small-sized lung adenocarcinoma by combining multi-modal information.
- Trial name
- NCT05830812
- Testing
- Invasiveness diagnosis
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Non-Small Cell Lung Cancer
Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment
This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine…
- Trial name
- NCT04852588
- Testing
- Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA), Transesophageal ultrasound-guided fine needle aspiration (EUS-FNA)
- Where
- 2 sites in Canada
- Volunteers
- 29 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Carcinoma, Non-small Cell Lung Cancer
Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
This is a single center, prospective and observational study conducted in three stages to predict the NSCLC lymph node metastasis based on ctDNA/specific methylation molecular features combined with PET-CT imaging features and…
- Trial name
- NCT06358222
- Testing
- Blood ctDNA + methylation + PET-CT and Postoperative pathology, MRD+ methylation (or combined with PET-CT) and Invasive mediastinoscopy /EBUS-TBNA, Intraoperative lymph node dissection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Non Small Cell Lung Cancer
The Development, Safety, and Feasibility of an Artificial Intelligence-Powered Platform (NodeAI) for Real-Time Prediction of Mediastinal Lymph Node Malignancy During Endobronchial Ultrasound Staging for Lung Cancer
Lung cancer is the leading cause of annual cancer deaths globally, more than breast, prostate, and colon cancers combined. The staging of chest lymph nodes (LNs) is a crucial step in the lung cancer diagnostic pathway because it…
- Trial name
- NodeAI (NCT06540196)
- Testing
- NodeAI, Surgeon
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Lung Non-Small Cell Carcinoma
A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients…
- Trial name
- NCT07293247
- Testing
- Chemotherapy, Immunotherapy, Intensity-Modulated Radiation Therapy
- Where
- 125 sites in United States
- Volunteers
- 164 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Locally Advanced Non-Small Cell Lung Cancer, Stage IIIb Non-small Cell Lung Cancer
Neoadjuvant SBRT Followed by Sintilimab Plus Chemotherapy for N3-Positive NSCLC
This is a Phase II clinical trial evaluating the efficacy and safety of a new treatment approach for patients with locally advanced non-small cell lung cancer (NSCLC) that has spread to lymph nodes on the opposite side of the…
- Conditions
- Locally Advanced Non-Small Cell Lung Cancer, Stage IIIb Non-small Cell Lung Cancer, Stage IIIC Non-Small Cell Lung Cancer
- Trial name
- SACTION 2501 (NCT07309952)
- Testing
- Sintilimab, Paclitaxel, Carboplatin (AUC 5)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Yang Hong
Carcinoma, Non-Small-Cell Lung
SLND or Not in cT1 GGO Invasive Lung Adenocarcinoma (ECTOP-1009)
This is a study from Eastern Cooperative Thoracic Oncology Project, numbered as ECTOP-1009. Systematically mediastinal lymph node dissection or not in clinical stage T1 ground-glass dominated invasive lung adenocarcinoma: a…
- Trial name
- NCT04527419
- Testing
- No mediastinal lymph node dissection
- Where
- China
- Volunteers
- 545 people
- Sponsor
- Fudan University
Lung Cancer
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)
It is reported that more than 90,000 patients died of lung cancer and more than 20% of them were older than 80 years in North America.
- Trial name
- NCT01786590
- Testing
- EBUS-TBNA
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Lung Neoplasms, Lymph Node Excision
Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage I GGN NSCLC
Lung cancer is the leading cause of cancer related death worldwide. Lobectomy or sub-lobectomy with mediastinal lymph node dissection is the standard surgery. About 50% lung nodules are pure ground-glass or part-solid nodules.
- Trial name
- NCT04631770
- Testing
- Systemic mediastinal lymph node dissection, Spared mediastinal lymph node dissection
- Where
- China
- Volunteers
- 1,362 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Ultracentral Pulmonary Tumors, Lung Cancer (T1 N0 M0 and T2 N0 M0)
Multicentre Phase II Trial Evaluating Stereotactic Body Radiotherapy on Ultra-central Lung Tumors on MR-Linac
Phase II multicenter trial evaluating the safety, tolerability, and feasibility of MRI-guided stereotactic radiotherapy using MRI-LINAC in patients with ultracentral lung tumors or lymphadenopathy in the context of controlled…
- Conditions
- Ultracentral Pulmonary Tumors, Lung Cancer (T1 N0 M0 and T2 N0 M0), Mediastinal Lymph Node Recurrence From All Types of Primary Cancer, Pulmonary Node Recurrence From All Types of Primary Cancer
- Trial name
- LIN-LUNG-2504 (NCT07733219)
- Testing
- MRI-LINAC radiotherapy
- Volunteers
- 59 people
- Sponsor
- Centre Oscar Lambret
NSCLC, Non Small Cell Lung Cancer
Radical Resection With Contralateral Lymph Node Dissection for Clinical N3 NSCLC
*Study Overview This study is investigating a surgical approach for patients with a serious type of lung cancer known as non-small cell lung cancer (NSCLC), particularly those in an advanced stage where cancer has spread to both…
- Trial name
- NCT07003490
- Testing
- Radical Resection with Bilateral Lymph Node Dissection
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine