Clinical trials: Lung Cancer Prevention
Breast Cancer, Colorectal Cancer
Improving Cancer Screening and Prevention During the COVID-19 Pandemic in Underserved Populations of Rhode Island
Lifespan Cancer Institute serves over 50% of cancer patients in the state. Rhode Island is known for strong medical care and high rates of cancer screening with mammography and colonoscopy.
- Conditions
- Breast Cancer, Colorectal Cancer, Covid19
- Trial name
- NCT04587258
- Testing
- Informational videos and social media campaigns encouraging cancer screening.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rhode Island Hospital
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Non-small Cell Lung Cancer
Huaier Granule for Prevention of Recurrence and Metastasis of Stage II and III Non-small Cell Lung Cancer (NSCLC)
This study including two parts，one part is a randomized clinical trial design，another part is a registration study.
- Trial name
- NCT03198117
- Testing
- Huaier Granule
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Qidong Gaitianli Medicines Co., Ltd
Cancer, Covid-19
Immunization With IMM-101 vs Observation for Prevention of Respiratory and Severe COVID-19 Related Infections in Cancer Patients at Increased Risk of Exposure
The purpose of this study is to find out if immunization with IMM-101 will reduce the incidence of severe respiratory and COVID-19 infections in cancer patients.
- Trial name
- COV-IMMUNO (NCT04442048)
- Testing
- IMM-101, Observation
- Where
- 8 sites in Canada
- Volunteers
- 195 people
- Sponsor
- Canadian Cancer Trials Group
Prevention and Control
PrOVE QUERI Project #1
The overall goal of this project is to test two strategies for implementing a shared decision making tool to be used by providers while talking to patients about lung cancer screening.
- Trial name
- NCT02765412
- Testing
- Webinar, Promotion, and Tool Access, LEAP, Audit and Feedback
- Where
- 8 sites in United States
- Volunteers
- 17,033 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Covid19
PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V
COVID-19 (SARS-CoV2 virus) was declared a global pandemic by the WHO on 11th March 2020. Currently there are no drugs proven to prevent COVID-19 or to reduce the severity of illness if given as prophylaxis.
- Trial name
- PROTECT-V (NCT04870333)
- Testing
- Niclosamide, Ciclesonide, Sotrovimab
- Where
- 45 sites in United Kingdom
- Volunteers
- 2,240 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Head and Neck Cancer, Lung Cancer
Subcutaneous Amifostine Safety Study
Amifostine is a radioprotective drug which is approved by the US FDA for administration prior to each radiation treatment using the intravenous route. The study evaluated the safety of amifostine administered subcutaneously.
- Conditions
- Head and Neck Cancer, Lung Cancer, Lymphoma
- Trial name
- NCT00158041
- Testing
- Amifostine administered subcutaneously
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Venous Thromboembolism, Bleeding as Surgical Complication (Treatment)
Enoxaparin Versus Placebo for Venous Thromboembolism Prevention in Low Risk Cancer Patients After Surgical Procedures: a Randomized, Double Blind, Placebo Controlled Clinical Trial Pilot Study
Post-surgical bleeding is a major source of morbidity in cancer patients, and ramifications can include need for transfusion, increased length of hospital stay, unexpected return to the operating room, or even death.
- Conditions
- Venous Thromboembolism, Bleeding as Surgical Complication (Treatment), Deep Venous Thrombosis, Pulmonary Embolism
- Trial name
- NCT03988231
- Testing
- Receipt of enoxaparin
- Sponsor
- University of Utah
Lung Cancer, Lung Cancer Screening
Prevention of Smoking Related Diseases
This is a prospective, observational, monocentric study. This study wants to test if among a smoking cessation intervention, behavioural counselling by video session is related to higher compliance and higher success rate than…
- Conditions
- Lung Cancer, Lung Cancer Screening, Smoking Cessation
- Trial name
- LSP-3 (NCT06451029)
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- Scientific Institute San Raffaele
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Esophagitis, Pneumonitis
Subcutaneous Amifostine (Ethyol®) in the Prevention of Radiochemotherapy-Induced Esophagitis and Pneumonitis in Patients With Unresectable Non-Small Cell Lung Cancer
The primary objective of this study is to assess the activity of subcutaneous (SC) amifostine on the incidence and severity of acute radiochemotherapy-induced esophagitis in patients with unresectable Stage IIIA or IIIB non-small…
- Conditions
- Esophagitis, Pneumonitis, Non-Small Cell Lung Carcinoma
- Trial name
- NCT00081315
- Testing
- Amifostine
- Where
- 24 sites in United States
- Volunteers
- 130 people
- Sponsor
- MedImmune LLC
Chemotherapy-induced Nausea and Vomiting, Lung Cancer
Olanzapine for the Prevention and Treatment of Nausea and Vomiting Induced by Chemotherapy of Lung Cancer
Chemotherapy induced nausea and vomiting (CINV) is a common adverse effect in treatment of cancer, which influences the quality of life and adherence to treatment of patients and leads to dehydration, malnutrition and even death.
- Trial name
- NCT03571126
- Testing
- Olanzapine
- Where
- 2 sites in China
- Volunteers
- 156 people
- Sponsor
- Zunyi Medical College
Lung Carcinoma
Iloprost in Preventing Lung Cancer in Former Smokers
This phase I trial studies the side effects and best dose of iloprost compared with a placebo in preventing lung cancer in former smokers. Chemoprevention is the use of drugs to keep cancer from forming or coming back.
- Trial name
- NCT02237183
- Testing
- Iloprost, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer, Head and Neck Cancer
SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss
Chemotherapy treatment with platinum based agents is well noted to cause ototoxicity. It is the objective of this study to determine the safety and efficacy of SPI-1005 at three dose levels when delivered orally twice daily for 3…
- Conditions
- Lung Cancer, Head and Neck Cancer, Hearing Loss, Ototoxicity
- Trial name
- NCT01451853
- Testing
- SPI-1005 Low Dose, SPI-1005 Middle Dose, SPI-1005 High Dose
- Where
- United States
- Sponsor
- Sound Pharmaceuticals, Incorporated
Hematological Malignancies
Rituximab for Prevention of Chronic GVHD
The purpose of this trial is to determine if administration of rituximab after allogeneic stem cell transplantation can reduce the incidence of chronic GVHD.
- Trial name
- NCT00379587
- Testing
- Rituximab, 375 mg/m2 RRituximab
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Dana-Farber Cancer Institute
Pancreatic Cancer, Venous Thromboembolism
Dalteparin for Primary Venous Thromboembolism (VTE) Prophylaxis in Pancreatic Cancer Patients
The goal of this clinical research study is to learn if dalteparin can lower the risk of VTE occurring in the legs and lungs. This will be tested in patients with pancreatic cancer who are going to receive chemotherapy.
- Trial name
- NCT00966277
- Testing
- Dalteparin
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Non-Squamous Non-Small Cell Carcinoma, Radiation-Induced Pneumonitis
Nintedanib Compared With Placebo in Treating Against Radiation-Induced Pneumonitis in Patients With Non-small Cell Lung Cancer That Cannot Be Removed by Surgery and Are Undergoing Chemoradiation Therapy
This trial studies the side effects and how well nintedanib works compared to a placebo in treating against radiation-induced pneumonitis (inflammation of the lungs) in patients with non-small cell lung cancer that cannot be…
- Conditions
- Lung Non-Squamous Non-Small Cell Carcinoma, Radiation-Induced Pneumonitis, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Non-Small Cell Carcinoma AJCC v7
- Trial name
- NCT02452463
- Testing
- Durvalumab, Nintedanib, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Roswell Park Cancer Institute
Lung Cancer, Atrial Fibrillation
PREvention of Atrial Fibrillation in patientS Undergoing thorAcic surGEry for Lung Cancer
The aim of this study is to assess whether prophylactic treatment with metoprolol or losartan is able to reduce the incidence of atrial fibrillation (AF) in patients undergoing thoracic surgery for lung cancer, showing elevated…
- Trial name
- PRESAGE (NCT01281787)
- Testing
- Metoprolol, Losartan
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- European Institute of Oncology
Venous Thromboembolic Disease, Pulmonary Embolism
CHIPs-VTE Study in Hospitalized Patients With Lung Cancer
Venous thromboembolism (VTE) is a common complication of malignancies, in particular to lung cancer. Patients with lung cancer in surgical and medical departments are at high risk of VTE development.
- Conditions
- Venous Thromboembolic Disease, Pulmonary Embolism, Deep Venous Thrombosis
- Trial name
- NCT04158973
- Testing
- Bleeding-risk based prophylaxis strategy during hospitalization and extended pharmacological treatment after discharge, Routine VTE prophylaxis in hospital
- Volunteers
- 3,200 people
- Sponsor
- China-Japan Friendship Hospital
Non-small-Cell Lung Cancer
Clinical Trial for Post-marketing Evaluation of Sheng Bai Oral Liquid
The purpose of the study is to evaluate the efficacy and safety of Sheng Bai oral liquid in prevention and treatment of the decrease of neutrophilics after chemotherapy in patients with non-small-cell lung cancer.
- Trial name
- NCT03413358
- Testing
- Sheng Bai oral liquid, Platinum-based two medicine (carboplatin / cisplatin) .
- Where
- China
- Volunteers
- 240 people
- Sponsor
- BeiJing Yijiayi Medicine Techonoloy Co., Ltd.