Clinical trials: Lung Cancer Screening
Lung Cancer Screening
A Study of Lung Cancer Screening in People With Unexplained Weight Loss
The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss.
- Trial name
- NCT06717334
- Testing
- Low Dose CT imaging, blood draws, screening questionnaire
- Where
- 8 sites in United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
Smoking Cessation, Smoking Cessation Counseling Ability and Practice
Evaluating the Impact of CONNECT in a Multilingual Population
This study aims to broaden the reach of the lung cancer screening (LCS) CONNECT program (NCT04149249, NCT06213532), by developing a version of the program to be available to multilingual communities.
- Conditions
- Smoking Cessation, Smoking Cessation Counseling Ability and Practice, Smoking Cessation Counselling, Lung Cancer Screening
- Trial name
- CONNECT-ML (NCT07111936)
- Testing
- CONNECT Intervention for multilingual populations, Saliva Sample, Interview
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancer Screening
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)
This research study aims to investigate methods for enhancing lung cancer screening. The study will investigate whether an artificial intelligence (AI) tool, known as Sybil, can aid in predicting the risk of lung cancer.
- Trial name
- NCT07408531
- Testing
- Sybil Artificial Intelligence (AI) screening
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Lung Cancer, Lung Cancer Screening
Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Lung Cancer
The purpose of this research study is to test a new process for diagnosing lung cancer by examining changes to your DNA that can be detected from a blood test.
- Conditions
- Lung Cancer, Lung Cancer Screening, Healthy Volunteers (HV), Unhealthy Volunteers
- Trial name
- NCT07008664
- Testing
- Epigenetic Signature Assay
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lung Cancer Screening
Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Health Services Research Intervention
This clinical trial studies statewide optimization of lung cancer screening (LCS) in Kentucky using the Quality Implementation of Lung Screening (QUILS™) System.
- Trial name
- NCT07682610
- Testing
- Quality Implementation of Lung Cancer Screening (QUILS) System
- Where
- 17 sites in United States
- Volunteers
- 35,500 people, healthy volunteers welcome
- Sponsor
- Timothy Mullett
Epigenetics, DNA Methylation
Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening
The MET-SELS study aims to revolutionize how we identify individuals for lung cancer screening by moving beyond the limitations of self-reported smoking history.
- Conditions
- Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker
- Trial name
- MET-SELS (NCT07631624)
- Testing
- DNA-methylation in saliva
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Screening Compliance, Lung Cancer (Diagnosis)
Increasing Lung Cancer Screening Uptake Among Emergency Department Patients
The objective of the proposed clinical trial is to determine if we can increase LCS among ED patients using a combination of facilitated referral to an LCS program plus text message reminders to get screened.
- Conditions
- Screening Compliance, Lung Cancer (Diagnosis), Lung Cancer Diagnosis, Lung Cancer
- Trial name
- NCT07287085
- Testing
- Facilitated referral and text messaging, Basic Referral (enhanced control arm)
- Where
- United States
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Lung Cancer Screening
Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America(LUCAS-LATAM)
Prospective study to assess lung cancer screening with low dose CT scan (LDCT) in Latin America (LATAM) and prospectively evaluate chest-XRay analyzed with artificial intelligence (AI) using qXRin (QURE ai) at the initial visit…
- Trial name
- LUCAS-LATAM (NCT07524803)
- Testing
- Chest X-Ray, Low Dose CT scan
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Latin American Consortium for the Lung Cancer Research
Lung Cancer, Lung Cancer Screening
Assessing the Effectiveness of Low-Dose Computed Tomography in Lung Cancer Screening for High-Risk Smokers: A Randomized Controlled Trial in Hong Kong
The investigators propose a randomized controlled trial to evaluate the clinical effectiveness of low-dose computed tomography (LDCT) for lung cancer screening in high-risk Chinese ever-smokers aged 50-79 years in Hong Kong and…
- Trial name
- NCT07478757
- Testing
- Low-dose computed tomography (LDCT)
- Where
- Hong Kong
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Lung Cancer (Diagnosis), Non-Small Cell Lung Cancer
Lung Cancer Screening in Population Who Had Never Smoked
Study design: prospective, single arm. Objectives: survey lung cancer detection rate of low-dose computed tomography (LDCT) screening in individuals who had never smoked.
- Conditions
- Lung Cancer (Diagnosis), Non-Small Cell Lung Cancer, Small Cell Carcinoma of Lung, Screening Strategy
- Trial name
- NCT07383454
- Testing
- Low dose computed tomography
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Lung Cancer, Lung Neoplasms
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening.
- Conditions
- Lung Cancer, Lung Neoplasms, Early Lung Cancer Detection, Cancer Screening
- Trial name
- NCT07358715
- Testing
- Liquid Biopsy (SPOT-MAS Assay), Exosome-Based Liquid Biopsy Assay, Low-Dose CT Thorax (LDCT)
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Smoking, Smoking Cessation
Digitally Enhanced Smoking Cessation for High Risk Smokers
This is a research study, is testing a program to improve lung health through smoking cessation and providing education around lung screening.
- Conditions
- Smoking, Smoking Cessation, Lung Cancer Screening, Smoking, Tobacco
- Trial name
- NCT04691297
- Testing
- Escape, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Lung Cancer Screening
Community-Based Engagement to Improve Lung Cancer Screening and Outcomes: The "Our Lungs Our Health" Study
The main goal of this pilot study is to understand the impact of a mobile lung cancer screening clinics in individuals from neighborhoods and communities with less access to resources in Boston, Massachusetts who are at high risk…
- Trial name
- NCT06909981
- Testing
- Low-Dose Computed Tomography Scan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lung Cancer Screening
LDCT-SC-FI Low-dose CT Screening for Lung Cancer
This is a randomized phase II trial investigating different smoking cessation methods in study subjects undergoing lung cancer screening with low-dose CT (LDCT).
- Trial name
- NCT05630950
- Testing
- Smoking cessation mobile application, Written material for smoking cessation
- Where
- 2 sites in Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Lung Cancer, Lung Cancer Screening
Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study
Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival.
- Conditions
- Lung Cancer, Lung Cancer Screening, Patient Empowerment
- Trial name
- NCT05645731
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nicole Ezer, MD, FRCPC, MPH
Lung Cancer Screening
A Randomized Controlled Trial Evaluating the Effectiveness of a Novel Risk-Stratified Screening Strategy for Lung Cancer
A nationwide population-based multi-center RCT enrolling ≥60,000 eligible residents to compare screening effectiveness between risk-prediction-model-driven and traditional guideline-based high-risk lung cancer screening…
- Trial name
- NCT07078032
- Testing
- Prediction Model Arm, Standard Screening Arm
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer Screening
CPRIT: Patient Adherence to Lung Cancer Screening
To understand participants' barriers to lung cancer screening and their experience with scheduling lung cancer screening.
- Trial name
- NCT06872723
- Testing
- Lung Cancer Screening
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer Screening Program
Inpatient Capture: A Mixed Methods Study to Develop an Inpatient Lung Cancer Screening Program in a Safety Net Hospital.
Lung cancer continues to be the leading cause of cancer death in the United States. There are several important disparities in lung cancer mortality: racial and ethnic minorities, those with serious mental illness and those with…
- Trial name
- NCT06876831
- Testing
- Shared decision making for LDCT (3 potential outcomes LDCT on discharge, scheduled date of LDCT, or Lung Cancer Screening referral), Inpatient Tobacco Cessation Counseling (Handouts, NYC Quits number, Medication Recommendations to primary team, Smoking cessation referral)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Physician Affiliate Group of New York
Lung Cancer Screening, Smoking Cessation
Gain-framed Messages and NRT for Lung Cancer Screening Patients
This research is a randomized smoking cessation trial conducted within and specifically personalized for lung cancer screening patients presenting to a lung screening clinic.
- Trial name
- NCT03069924
- Testing
- Gain-framed messaging, Unframed messaging materials
- Where
- 2 sites in United States
- Volunteers
- 367 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina