Clinical trials: Lung Disorder
Asthma, Hypersensitivity
A Study of Inhalation of 20,000 EU CCRE in Normal Volunteers Compared to Allergic Asthmatic Individuals
This will be a single center, open label study comparing baseline characteristics of recovered sputum cells (collected on screening day) to those of cells recovered 6 hours after inhalational challenge with 20,000 EU Clinical…
- Trial name
- Endomac (NCT00839124)
- Testing
- Clinical Center Reference Endotoxin (CCRE)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
COVID-19
COVID-19 Infection in Healthcare Workers
Introduction: The SARS-Cov-2 outbreak in France and the concomitant massive increase in the number of cases requiring hospital management create a major risk of COVID-19 infection for hospital staff.
- Trial name
- HOP-COVID (NCT04386759)
- Testing
- Cohort
- Where
- France
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
Biomarkers for Diagnosis and Treatment of COPD
COPD is an inflammatory disease characterized by enhanced chronic airway and lung inflammatory responses to noxious agents (e.g. smoke, pollutants) and progressive airflow limitation.
- Trial name
- BmiRCOPD (NCT02633280)
- Where
- 3 sites in Italy
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Asthma
A Clinical Study to Test the Safety, Exposure, and Pharmacodynamic Markers of CSL311 in Patients With Mild-to-moderate Asthma and in Healthy Volunteers
This is a phase 1, first-in-human (FIH), multi-center, randomized, double-blind, placebo-controlled study of CSL311 in patients with mild-to-moderate asthma.
- Trial name
- NCT04082754
- Testing
- Human beta common receptor antagonist monoclonal antibody
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- CSL Behring
Tuberculosis, Tuberculosis, Pulmonary
Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students
This study is a cross-sectional study that examines the prevalence of Latent Tuberculosis Infection [LTBI], defined as individuals infected with Mycobacterium tuberculosis with no clinical evidence of disease, and the possible…
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Tuberculosis Infection, Latent Tuberculosis
- Trial name
- CROSSWORD (NCT05756582)
- Testing
- Prevalence of Latent Tuberculosis Infection
- Where
- Italy
- Volunteers
- 2,040 people, healthy volunteers welcome
- Sponsor
- Eleonora Nucera
Chronic Obstructive Pulmonary Disease
Comparative Effects of Costophrenic Assisted Cough and Anterior Chest Compression Technique in COPD Patients
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing.
- Trial name
- NCT05922241
- Testing
- Costophrenic assisted cough, Anterior chest compression
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Asthma
Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate
This study aims to determine whether an extra virgin olive oil-based water (EVOOW) mixture removes more fluticasone propionate (FP) from the mouth than water alone.
- Trial name
- EVOOW (NCT07664527)
- Testing
- Fluticasone Propionate, Water Mouthwash, EVOOW Mouthwash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Severe Asthma
Evaluate the Pharmacokinetics of BAT2606 Injection in Healthy Chinese Male Subjects
To evaluate the pharmacokinetics, safety and immunogenicity of BAT2606 in healthy China male subjects.
- Trial name
- NCT05576454
- Testing
- Mepolizumab Injection (BAT2606 Injection), Mepolizumab Injection (EU-licensed Nucala), Mepolizumab Injection (US-licensed Nucala)
- Where
- China
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Bio-Thera Solutions
Obesity, Abdominal, Lung Disease
Abdominal Circumference and Cardiorespiratory Repercussions in Patients Submitted to Physical Therapy
The purpose of this study is to determine whether the hospitalized patients with increased waist circumference exhibit cardiorespiratory alterations after chest physical therapy.
- Trial name
- RACCRPPT (NCT02217423)
- Testing
- Chest physiotherapy chest wall expansion, Chest physiotherapy airway clearance modality
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Allergic Bronchopulmonary Aspergillosis
Phase 1 Three Part SAD, MAD & Cross-Over Study of ZP-059 in Healthy and Asthmatic Subjects
The primary safety objectives were: Part 1: To determine the safety and tolerability of single doses of ZP-059 in healthy subjects Part 2: To determine the safety and tolerability of multiple doses of ZP-059 in subjects with mild…
- Trial name
- NCT04229303
- Testing
- Voriconazole inhaled, oral voriconazole
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Zambon SpA
COVID-19
INFLUENCE OF HIGH FREQUENCY CHEST WALL OSCILLATION IN HOSPITALIZED PATIENTS WITH COVID-19
INFLUENCE OF HIGH FREQUENCY CHEST WALL OSCILLATION IN HOSPITALIZED PATIENTS WITH COVID-19 The purpose of this Interventional study is to investigate the effect of high frequency chest wall oscillation in hospitalized COVID-19…
- Trial name
- HFCWO IN COVID (NCT05705661)
- Testing
- HIGH FREQUENCY CHEST WALL OSCILLATION
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulmonary Disease
Thora-3Di™ Respiratory Rate Validation
Respiratory rate (RR) is a vital sign used to monitor clinical condition of a patient. Various devices using different techniques are available to measure RR.
- Trial name
- NCT02374554
- Testing
- Structured Light Plethysmography (Thora-3Di), BCI Capnograph 9004 (Smiths Medical)
- Where
- 2 sites in United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
COVID-19
Promoting Engagement and COVID-19 Testing for Health
PEACH2 is a community-based study, targeting individuals affected by diabetes. Study participants will be randomized into the PEACH2 Intervention Arm or the Control Arm.
- Trial name
- PEACH2 (NCT06141850)
- Testing
- COVID-19 Test Reporting, Personalized Nudges via Text Messaging, Non-personalized Nudges via Text Messaging
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Emory University
COVID-19
Health Professional Exposure Assessment to Covid-19
Understanding the SARS-Cov2 epidemic is a major public health issue, both in the community and in the hospital sector. Because of their central position in the management of patients infected with COVID-19, hospital staff may be…
- Trial name
- SERODRON (NCT04429724)
- Testing
- Diagnostic test Covid-19
- Where
- 4 sites in France
- Volunteers
- 2,129 people, healthy volunteers welcome
- Sponsor
- Tourcoing Hospital
Diagnostic Error
Quality of Medical History Taking and Diagnostic Accuracy
This prospective randomized simulator-based single-blind trial aimed to investigate the effects of initial cues and history taking skills on diagnostic accuracy
- Trial name
- NCT05760859
- Testing
- Initial cue
- Where
- Switzerland
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pulmonary Hypertension (Diagnosis)
Applying Artificial Intelligence to the 12 Lead ECG for the Diagnosis of Pulmonary Hypertension: an Observational Study
The goal of this observational study is to apply Artificial Intelligence (AI) and machine learning technology to the resting 12-lead electrocardiogram (ECG) and assess whether it can assist doctors in the early diagnosis of…
- Trial name
- NCT05942859
- Testing
- Artificial Intelligence and Machine Learning technology
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
COVID-19
International Validation of Wearable Sensor to Monitor COVID-19 Like Signs and Symptoms
1. Deploy wearable COVID sensor to collect high resolution physiological data (temperature, cardiac, respiratory and physical activity) from COVID positive patients. 2.
- Trial name
- NCT05334680
- Testing
- ANNE Sensor
- Where
- 3 sites in India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Arun Jayaraman, PT, PhD
Chronic Airway Disease, Interstitial Lung Disease
WTC Chest CT Imaging Archive
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016.
- Conditions
- Chronic Airway Disease, Interstitial Lung Disease, Lung Cancer
- Trial name
- NCT03295279
- Where
- United States
- Volunteers
- 2,122 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
COVID-19
A Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of Booster Vaccination With Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell)
The Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) developed by WestVac Biopharma Co., Ltd. is a monovalent modified vaccine designed against Omicron XBB.1.5.
- Trial name
- NCT06175494
- Testing
- Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell), Recombinant COVID-19 Variant Vaccine (Sf9 Cell)
- Where
- China
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- WestVac Biopharma Co., Ltd.
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