Clinical trials: Lung Function, open to volunteers
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Pulmonary Function
Service and Health Among Deployed Veterans
The purpose of the study is to better understand the health, including lung health, of Veterans who deployed in support of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), or Operation New Dawn (OND) and other…
- Trial name
- SHADE (NCT02825654)
- Where
- 6 sites in United States
- Volunteers
- 6,200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline
Respiratory Progression in Adults With Duchenne Muscular Dystrophy.
This is a multicenter, longitudinal observational study aimed at characterizing the natural history of respiratory progression in adults with genetically confirmed Duchenne muscular dystrophy (DMD).
- Conditions
- Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline, Restrictive Lung Disease, Respiratory Failure
- Trial name
- GUP24005 (NCT07879989)
- Where
- 13 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Age-Related Lung Function Decline
Ongoing Lung Decline With Age Intensified Response
This Phase II, randomized, double-blind, placebo-controlled pilot study will evaluate the effects of fisetin, a senolytic flavonoid compound, on lung function and biomarkers of cellular senescence in older adults aged 60 years…
- Trial name
- OLD AIR (NCT07676435)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Lung Function
eCPAP Follow-up at School Age
The purpose of the study is to learn more about extended continuous positive airway pressure (eCPAP) in preterm infants that may be helpful for lung health.
- Trial name
- NCT07860931
- Testing
- Extended CPAP (eCPAP)
- Volunteers
- 95 people
- Sponsor
- Cynthia McEvoy
Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema
Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE)
Acute or chronic cardiac dysfunction could be a contributing factor to swimming-induced pulmonary edema (SIPE). Knowledge on cardiac function in SIPE is limited and recommendations for cardiac evaluation of patients with SIPE are…
- Conditions
- Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema, Lung Diseases, Heart Function Tests
- Trial name
- NCT05391737
- Testing
- Echocardiography, Electrocardiogram (ECG), Cardiac biomarkers
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Lung Cancer (Diagnosis), Patient-Reported Symptom Burden
Symptoms, Physical Function, and Recovery in Patients Receiving Lung Cancer Treatment Before Surgery
This study will examine how symptoms and physical abilities change during lung cancer treatment given before planned surgery, and how these changes relate to recovery after surgery.
- Conditions
- Lung Cancer (Diagnosis), Patient-Reported Symptom Burden, Physical Function
- Trial name
- NCT07853443
- Testing
- Longitudinal Assessment of Symptoms, Physical Function, and Postoperative Recovery
- Volunteers
- 360 people
- Sponsor
- Aerospace Center Hospital
Respiratory Monitoring, Thoracic Surgery
AirGo™ Respiratory Monitoring in Lung Resection
Patients undergoing lung resection surgery may experience changes in respiratory function during the perioperative period. Current monitoring methods provide important clinical information but are often limited to specific time…
- Conditions
- Respiratory Monitoring, Thoracic Surgery, Lung Resection Surgery, Respiratory Function
- Trial name
- NCT07838025
- Testing
- AirGoTM system
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiorespiratory Fitness, Metabolic Health
Validation of a Novel Incremental Step Test for Assessment of Cardiopulmonary Fitness and Ventilatory Thresholds in Adults
The purpose of this single-group diagnostic validation and test-retest reliability study is to determine whether a novel Incremental Step Test (IST) can accurately assess cardiorespiratory fitness and ventilatory thresholds in…
- Conditions
- Cardiorespiratory Fitness, Metabolic Health, Cardiac Function, Pulmonary Function
- Trial name
- VALID-IST (NCT07829003)
- Testing
- Cardiopulmonary Exercise Test, Incremental Step Test
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heriot-Watt University
Breathing, Lung Function Decreased
Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function
This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.
- Conditions
- Breathing, Lung Function Decreased, MRI Imaging, Healthy
- Trial name
- PROOF (NCT07614685)
- Testing
- Airway Oscillometer, Phase Resolved Functional Lung MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Tuberculosis, Inflammation Biomarkers
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
The goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients…
- Conditions
- Tuberculosis, Inflammation Biomarkers, Liver Function Tests, Iron Status
- Trial name
- TREAT 3 (NCT07118059)
- Testing
- Omega-3 (EPA+DHA)
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- North-West University, South Africa
Healthy, Healthy Adult
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07804537
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in patients with pulmonary…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude Effects, High Altitude
- Trial name
- NCT07804576
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Function, Aerobic Performance
Pulmonary Function and Trunk Muscle Performance in Wrestlers
This study aims to investigate the relationships among pulmonary function, aerobic performance, anaerobic performance, and isokinetic trunk muscle performance in professional male wrestlers.
- Conditions
- Pulmonary Function, Aerobic Performance, Anaerobic Performance, Isokinetic Test
- Trial name
- NCT07792174
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pulmonary Function, Post Operative Pain Control
Comparison of M-TAPA and ESPB for Postoperative Pulmonary Function After Laparoscopic Cholecystectomy
This prospective, randomized, controlled clinical trial aims to compare the effects of two ultrasound-guided fascial plane blocks, the Erector Spinae Plane Block (ESPB) and the Modified Thoracoabdominal Nerve Block through…
- Trial name
- NCT07666646
- Testing
- Modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA), Erector spinae plane block (ESPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kayseri City Hospital
Bronchial Asthma, Vitamin D Deficiency
Vitamin D Status and Asthma Control, Pulmonary Function, and Oxidative Stress in Adults With Bronchial Asthma
Asthma is a chronic inflammatory airway disease associated with variable airflow limitation and persistent respiratory symptoms.
- Conditions
- Bronchial Asthma, Vitamin D Deficiency, Pulmonary Function Impairment, Oxidative Stress
- Trial name
- VD-ASTHMA (NCT07733635)
- Volunteers
- 134 people
- Sponsor
- Sinai University
Lung Function Decreased, Surgery
Tubeless Surgery With Impaired Pulmonary Function
Some patients with impaired lung function require minimally invasive surgical treatment, including those with lung cancer, benign lung tumors, pneumothorax, or lung volume reduction surgery.
- Trial name
- NCT06848751
- Testing
- Non-intubated thoracoscopic surgery
- Where
- China
- Volunteers
- 45 people
- Sponsor
- The Second Hospital of Shandong University
Asthma (Diagnosis), Pulmonary Function
Effect of Linvemastat in Patients With Partially Controlled Asthma (syMMPonia)
This study explores a potential new treatment for adults with moderate-to-severe asthma using a drug called linvemastat, which targets an enzyme linked to lung inflammation.
- Conditions
- Asthma (Diagnosis), Pulmonary Function, Moderate-to-Severe Asthma
- Trial name
- syMMPonia (NCT07191535)
- Testing
- linvemastat
- Volunteers
- 135 people
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.
Postoperative Pain, Pulmonary Function Tests
The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery
In adult patients undergoing cardiac surgery, does adding an sPIP block to standard care compared to standard care alone result in a smaller decrease in PFTs?
- Trial name
- PIPACS (NCT05999721)
- Testing
- superficial parasternal intercostal plane block, Standard care
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Shai Fein
Lung Surgery, Right Ventricular Function
RIght VEntricle Response to Major Lung Resection in VATS and Robotic Surgery
Major pulmonary resection is associated with high postoperative morbidity and mortality, mainly due to cardiorespiratory complications.
- Trial name
- RIVER-2 (NCT07362342)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas