Clinical trials: Lung Ground-glass Opacities
Pulmonary Nodule, Solitary
Is Bronchoscopy Necessary in the Preoperative Workup of GGO Lung Cancer?(ECTOP-1005)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1005). It aims to evaluate the role of flexible bronchoscopy in the pre-operative workup of ground glass opacity featured lung cancer.
- Trial name
- NCT03591445
- Testing
- Flexible Bronchoscopy
- Where
- China
- Volunteers
- 615 people
- Sponsor
- Fudan University
Thoracic Surgery, Video-Assisted
Preoperative Stereoscopic Localization Versus Methylene Blue Localization in GGO Wedge Resection
This study evaluates the feasibility，accuracy and safety of Preoperative Stereoscopic Localization Versus Methylene Blue Localization in GGO Wedge Resection.
- Trial name
- PSLVML (NCT03252210)
- Testing
- Preoperative Stereoscopic Localization
- Volunteers
- 20 people
- Sponsor
- Guangdong Provincial People's Hospital
Lung Neoplasms, Surgery
Comparison Between Wedge Resection and Segmentectomy for Ground Glass Opacity- Dominant Stage IA NSCLC
The purpose of this study is to evaluate whether the long-term outcome and safety of wedge resection are comparable to segmentectomy for the surgical treatment of early stage (IA) non-small cell lung cancer (NSCLC). Zhang et al.
- Trial name
- NCT02718365
- Testing
- Wedge resection, Segmentectomy
- Where
- China
- Volunteers
- 1,382 people
- Sponsor
- West China Hospital
Pulmonary Nodules, Ground-glass Opacity
Percutaneous Robotic Navigation Microwave Ablation Versus CT-guided Microwave Ablation in the Treatment of Pulmonary Nodules With Ground-glass Opacity
1. To compare the precision of robot-guided microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules. 2.
- Trial name
- NCT07389889
- Testing
- Robot, CT scan
- Volunteers
- 116 people
- Sponsor
- Fujian Medical University Union Hospital
Lung Neoplasms, Carcinoma Non-small-cell Lung
A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing
The investigators are doing this research to see if they can use small tissue samples or fluid to develop a test that will determine if the tissue samples are related or not related to each other.
- Trial name
- NCT02705404
- Testing
- Multifocal Tissue Banking
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Lung Nodules, Ultrasound
Ultrahigh-frequency Ultrasonography (UHFUS) in Detection of Small Pulmonary Ground Glass Opacity (GGO)
The purpose of this study is to assess the feasibility of UHFUS on detection of GGOs in excised lung tissue and investigate UHFUS features of GGO in vitro. Each GGO was detected by palpation, UHFUS and open biopsy in sequence.
- Conditions
- Lung Nodules, Ultrasound, Detection Rate
- Trial name
- UHFUSGGO (NCT05994898)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Ground-Glass Opacity
Cryoablation vs Thoracoscopic Surgery for GGN
The aim of this study is to investigate the efficacy and safety of Cryoablation and Thoracoscopic Surgery in the treatment of pulmonary ground-glass nodules.
- Trial name
- NCT06848881
- Testing
- Cryoablation, Thoracoscopic Surgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Neoadjuvant Aumolertinib in Patients With AI-diagnosed EGFR-mutant High-risk Pulmonary Ground-glass Opacity.
This is a prospective, single-center, single-arm, phase II study evaluating the efficacy and safety of neoadjuvant aumolertinib in previously untreated patients with AI-diagnosed EGFR-mutant and resectable pulmonary ground-glass…
- Trial name
- NCT05946460
- Testing
- Aumolertinib
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Ground-Glass Opacity
The Efficacy and Safety of TBCB vs TBFB in Diagnosis of GGO
The aim of this study is to investigate the difference of efficacy and safety between transbronchial cryobiopsy (TBCB) and transbronchial forceps biopsy (TBFB) in the diagnosis of lung ground-glass opacity.
- Trial name
- NCT04727190
- Testing
- Transbronchial Cryobiopsy, Transbronchial Forceps Biopsy
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Lesion With Ground-glass-opacity
Lipiodol Localization for Ground-glass-opacity Minimal Surgery
The study object is to demonstrate the usefulness and safety of lipiodol localization technique for individuals undergoing ground-glass opacity (GGO) Video-assisted thoracic surgery (VATS) resection compared to hook wire…
- Trial name
- LOGIS (NCT02180568)
- Testing
- Lipiodol, Hookwire
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Severance Hospital
Lung Neoplasms
Safety and Feasibility of Pulmonary Surgery Marker System in the Intraoperative Localization of Small Pulmonary Nodules
As the detection of small pulmonary nodules continuously grows, the intraoperative localization of small pulmonary nodules is in great demand.
- Trial name
- NCT04211051
- Testing
- LungBrella marker implantation and VATS partial lobe resection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Lung Ground-glass Opacities, Active Surveillance
Active Surveillance for Limited GGNs
This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) .
- Trial name
- NCT06394037
- Testing
- Active surveillance
- Where
- China
- Volunteers
- 387 people
- Sponsor
- Fudan University
Lymph Node Metastases, Non-small Cell Lung Cancer Stage I
Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1003. Systemic mediastinal lymphadenectomy is deemed indispensable in lung cancer surgery for accurate staging and complete…
- Trial name
- NCT03216551
- Testing
- Intra-operative frozen section
- Where
- China
- Volunteers
- 1,076 people
- Sponsor
- Fudan University
Lung Ground-glass Opacities, Active Surveillance
Surveillance for Multifocal GGNs
This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) with the identification number ECTOP-1021.
- Trial name
- NCT06097910
- Testing
- Watchful waiting
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Fudan University
Lung Neoplasms, Carcinoma Non-small-cell Lung
Treatment of Multifocal Lung Adenocarcinoma
To gather preliminary safety and outcome data for the multimodality treatment of lung adenocarcinoma in the setting of multifocal BAC.
- Conditions
- Lung Neoplasms, Carcinoma Non-small-cell Lung, Adenocarcinoma
- Trial name
- NCT01946100
- Testing
- Multifocal Lung Adenocarcinoma
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Pulmonary Lesions
Study of Ablation for the Pulmonary Focal Pure Ground Glass Opacity (pGGO)
With the advent of CT screening for lung cancer, there is an increase in the detection of pulmonary lesions with focal pure ground-glass opacity (pGGO).
- Trial name
- pGGO (NCT01429649)
- Testing
- cryotherapy or radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Lung Ground-Glass Opacity
GGO-dominant PPLs Diagnosis Using CLE and ssRAB-guided Cryobiopsy
The purpose of the study is to evaluate the diagnostic performance and safety of cryobiopsy for ground-glass opacity (GGO)-dominant peripheral pulmonary lesions (PPLs) under the guidance of shape-sensing robotic-assisted…
- Trial name
- NCT06910046
- Testing
- CLE and ssRAB-guided cryobiopsy
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Osimertinib to Suppress the Progression of GGN(EGFR Mutation-positive)
This study designed to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR mutation-positive stage I lung…
- Trial name
- NCT04591002
- Testing
- Osimertinib 80 MG
- Where
- 2 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Pulmonary Nodules, Lung Neoplasms
Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CT
Pulmonary ground-glass nodules (GGNs) are commonly found on chest CT scans. Some stay stable for years, while others slowly or rapidly turn into lung cancer.
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Adenocarcinoma of Lung
- Trial name
- GGN-Trajectory (NCT07647692)
- Testing
- Serial Thin-Slice Chest CT
- Where
- China
- Volunteers
- 4,750 people
- Sponsor
- Peking University People's Hospital
Segmentectomy
3D Reconstruction in Video-assisted Thoracoscopic Surgery (VATS) Segmentectomy
Anatomical variations of pulmonary vessel may cause serious problems during pulmonary segmentectomy. Three-dimensional （3D）computed tomography (CT) presents 3D images of pulmonary vessels and the tracheobronchial tree and may…
- Trial name
- DRIVATS (NCT04004494)
- Testing
- 3D reconstruction
- Where
- 3 sites in China
- Volunteers
- 191 people
- Sponsor
- Ruijin Hospital