Clinical trials: Lung Lesions
Lung Cancer
Transbronchial Catheter Aspiration and Transbronchial Needle Aspiration in the Diagnosis of Lung Cancer
The aim of this study is prospectively to determine the diagnostic sensitivity of Transbronchial Catheter Aspiration (TBCA) in comparison with Transbronchial Needle Aspiration (TBNA) in the diagnosis of peripheral nodules and…
- Trial name
- NCT00807391
- Testing
- TBCA, TBNA
- Where
- 2 sites in Germany
- Volunteers
- 48 people
- Sponsor
- Helios Klinik Ambrock
Cardiac Arrhythmia, Atrial Fibrillation
High Radiofrequency Power for Faster and Safer Pulmonary Veins Isolation - a Pilot Observational Study.
The POWER FAST I pilot study is a unicentric, observational, non-randomized controlled clinical study. In the control group pulmonary veins isolation was performded in consecutive patients with irrigated radiofrequency cateters…
- Conditions
- Cardiac Arrhythmia, Atrial Fibrillation, Atrial Tachycardia, Esophagus Injury
- Trial name
- POWER_FAST (NCT04162249)
- Testing
- Conventional LSI/AI-guided pulmonary veins ablation., High-power pulmonary veins ablation., Esophageal temperature monitoring
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Hospital Universitario La Paz
Peripheral Pulmonary Lesions, Lung Cancer
Peripheral EBUS With ROSE vs no ROSE; Slim Bronchoscope Without Guide Sheath vs Standard Bronchoscope With Guide Sheath
Peripheral pulmonary lesions (PPL) are defined as nodules or masses that are located in the lung periphery; hence cannot be seen via regular bronchoscopy.
- Trial name
- NCT03809169
- Testing
- Rapid on-site evaluation (ROSE), Slim bronchoscope without a guide sheath, Standard pEBUS with guide sheath
- Where
- 2 sites in Canada
- Volunteers
- 186 people
- Sponsor
- University of Calgary
Lung Cancer
EBUS-GS-TBLB With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the efficacy and safety of endobronchial ultrasound-guide sheath(EBUS-GS) for the diagnosis of peripheral pulmonary lesions (PPLs) without radiographic fluoroscopy.
- Trial name
- NCT01895166
- Testing
- EBUS-GS, X-ray
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Lung Lesions
Comparison of the Diagnostic Accuracy: US-guided Percutaneous Lung Biopsies vs CT-guided in Peripheral Lung Lesions
A non-sponsored prospective randomized single-blind national multicenter interventional study which aims to compare the diagnostic accuracy between US-guided percutaneous lung needle biopsies and CT-guided in peripheral lung…
- Trial name
- SULTAN (NCT06412289)
- Testing
- US-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY, CT-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY
- Where
- 2 sites in Italy
- Volunteers
- 236 people
- Sponsor
- University Hospital of Ferrara
Lung Cancer,, Mediastinal Tumors,
Virtual Bronchoscopy (VB) vs. Endobronchial Ultrasound (EBUS) Guided Mediastinal Sampling
The study has been designed to evaluate the clinical application of the new virtual bronchoscopy (VB) -based system for transbronchial sampling of the mediastinal masses or enlarged lymph nodes.
- Conditions
- Lung Cancer,, Mediastinal Tumors,, Lymphomas,, Sarcoidosis,
- Trial name
- VB/EBUS-TBNA (NCT01784185)
- Testing
- virtual bronchoscopy guided transbronchial needle aspiration, endobronchial ultrasound guided transbronchial needle aspiration
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Thorax Cancer
Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions
The purpose of this study, is to investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions.
- Trial name
- DWIMRICSPL (NCT02482181)
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- ÇAĞLAYAN ÇAKIR
Lung; Node
Robotic Systems Evaluation for Peripheral Pulmonary Lesions (RISE Trial)
This is an investigator-initiated cluster randomized control trial. The primary objective is to compare the diagnostic yield of two Food and Drug Administration (FDA) cleared national robotic assisted bronchoscopy platforms - the…
- Trial name
- NCT07735611
- Testing
- RAB via the Monarch platform, RAB via the ION platform
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- Case Comprehensive Cancer Center
Lung Cancer
Conventional vs Ultrathin Bronchoscopy for Peripheral Pulmonary Lesions
This study's purpose is to evaluate whether the use of an ultra-thin bronchoscope can improve sensitivity and diagnostic yield in peripheral pulmonary nodules.
- Trial name
- NCT04029155
- Testing
- Lung biopsy
- Volunteers
- 142 people
- Sponsor
- Stefano Gasparini
Posterior Fossa Hemorrhage, Lung Cancer
Pilot Study of Model Based Iterative Reconstruction Using 64-Slice
This study is being performed to confirm that the new technique, Model-Based Iterative Reconstruction (MBIR) with reduced radiation dose can deliver equivalent image quality for CT scans compared to current techniques (Filtered…
- Conditions
- Posterior Fossa Hemorrhage, Lung Cancer, Flank Pain, Urolithiasis
- Trial name
- MBIR (NCT01431378)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Elasticity Imaging Techniques
Transthoracic Shear-wave Ultrasound Elastography
This study aims to provide the information of tissue elasticity in different etiologies of pulmonary lesions and to validate the predictive value of shear-wave elastography in differentiating benign pulmonary lesions from…
- Trial name
- NCT03376425
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- National Taiwan University Hospital
Squamous Cell Lung Cancer, Lung Cancer
Photodynamic Therapy for the Prevention of Lung Cancer
PEARL is a phase III multicentre 2:1 randomised controlled trial, with an incorporated phase II (pilot) component. All patients consented/registered onto the trial will have an autofluorescence bronchoscopy (AFB) to check for the…
- Trial name
- PEARL (NCT03346304)
- Testing
- Photodynamic Therapy (PDT)
- Sponsor
- University College, London
Dementia, Parkinson Disease
Data Collection Study for the Spectrum Dynamics Multi-purpose CZT SPECT Camera
This study evaluates SPECT image data acquired from Spectrum Dynamics' multi-purpose CZT SPECT-CT camera. All subjects will undergo routine clinical Anger SPECT imaging and an additional SPECT acquisition on the CZT SPECT camera.
- Conditions
- Dementia, Parkinson Disease, Pulmonary Hypertension, Heart Diseases
- Trial name
- NCT03438123
- Testing
- CZT SPECT imaging
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Spectrum Dynamics
Tuberculosis, Multi-Drug Resistant Tuberculosis
Metronidazole for Pulmonary Tuberculosis (South Korea)
This study will evaluate the effect of adding metronidazole to standard second-line therapy for tuberculosis in patients who have multi-drug resistant tuberculosis (MDR-TB) of the lungs.
- Trial name
- NCT00425113
- Testing
- Metronidazole, Blood Draw, CT Scan
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-Small Cell Carcinoma of Lung, TNM Stage 4, Radiation Therapy
Radiotherapy to the Primary in Metastatic Non-small Cell Lung Cancer Patients
study the effect of radiotherapy to the primary lesion after first line systemic therapy in metastatic non-small cell lung cancer patients.
- Trial name
- NCT04776083
- Testing
- first line systemic therapy, 3D radiotherapy or IMRT
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Menoufia University
Lung Lesion(s) Requiring Evaluation
Transbronchial Lung Biopsy Guided by ENB
The purpose of this study is to evaluate the performance and safety of electromagnetic navigation bronchoscopy (ENB) system and system kit (iLungTM SuperNavigator) .
- Trial name
- NCT03628222
- Testing
- ENB-TBLB, X-ray-TBLB
- Where
- 8 sites in China
- Volunteers
- 226 people
- Sponsor
- Changzhou LungHealth Medtech Company Limited
Non Small Cell Lung Cancer
OPTIMISE Lung SABR
This study is a phase II multi-centre, randomised study independently evaluating five fraction Image-Guided Stereotactic Ablative Radiotherapy (IG-SABR) and three fraction IG-SABR for patients with a peripherally located T1-T2…
- Trial name
- NCT07777614
- Testing
- Five fraction Image-guided Stereotactic Ablative Radiotherapy (IG-SABR) treatment, Investigational three fraction image-guided Stereotactic Ablative Radiotherapy (IG-SABR)
- Where
- Ireland
- Volunteers
- 208 people
- Sponsor
- Cancer Trials Ireland
Pulmonary Coin Lesion, Colon Cancer Liver Metastasis
Optical Detection of Malignancy During Percutaneous Interventions
Investigation of application possibilities of optical spectroscopy within the field of oncology. Optical spectroscopy enables the possibility to specifically differentiate between different (human) tissues.
- Conditions
- Pulmonary Coin Lesion, Colon Cancer Liver Metastasis, Breast Cancer
- Trial name
- NCT01730365
- Testing
- Core biopsy procedure
- Where
- Netherlands
- Volunteers
- 104 people
- Sponsor
- Philips Healthcare
Endobronchial Ultrasound
EBUS Image Features in the Diagnosis of PPLs
The study is aimed to evaluate the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of endobronchial ultrasound (EBUS) image features in diagnosing peripheral pulmonary lesions…
- Trial name
- NCT03575715
- Testing
- EBUS
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Heart Defects, Congenital
Safety and Performance of a Vascular Patch in Pediatric Patients Undergoing Bidirectional Cava-pulmonary Anastomosis
Xeltis developed biodegradable patch prosthesis, the Vascular Patch Model COR-VP-001, to be used as a vascular patch to augment the pulmonary trunk and pulmonary arteries.
- Trial name
- XEL-CR-06 (NCT02377700)
- Testing
- Xeltis Vascular Patch, Model COR-VP-001
- Where
- Russia
- Volunteers
- 5 people
- Sponsor
- Xeltis