Clinical trials: Lung Lesions
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Pulmonary Nodule, Bronchoscopy
Comparative Performance of Robotic, Electromagnetic Navigation and Fluoroscopy Drives Optimal Diagnostic Strategy for Peripheral Pulmonary Lesions
Currently, the optimal method for Peripheral Pulmonary Lesions (PPL) is uncertain. We aim to compare the diagnostic yield of Robotic Bronchoscopy System (RBS), Electromagnetic Navigation Bronchoscopy (ENB)…
- Trial name
- NCT06701448
- Testing
- robotic bronchosopy, Electromagnetic Navigation Bronchoscopy, Fluoroscopy bronchoscopy
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Guangzhou Medical University
Langerhans Cell Histiocytosis (LCH)
Luvometinib in Pediatric SS-LCH With Special-site Single/Multifocal Bone Lesions
Langerhans cell histiocytosis (LCH) is the most common type of histiocytic disorder in children, affecting about 2.6 to 8.9 out of every million kids each year.
- Trial name
- NCT07371182
- Testing
- Luvometinib
- Where
- 11 sites in China
- Volunteers
- 62 people
- Sponsor
- West China Second University Hospital
Pulmonary Parenchymal Lesions
Comparing the Diagnostic Yield of Radial EBUS Guided Biopsies When Using a Thick (1.7mm) Vs. Thin (1.4 mm) USS Probe.
Obtaining a tissue sample to diagnose parenchymal lung lesions (PPL) suspected of cancerous origin is of utmost importance. Due to it's markedly favourable safety profile, a bronchoscopic biopsy method called Radial EBUS is…
- Trial name
- R-EBUST2 (NCT02739126)
- Testing
- Radial EBUS biopsy, Types of Radial Ultrasound probes
- Where
- New Zealand
- Volunteers
- 88 people
- Sponsor
- Middlemore Hospital, New Zealand
Vaccination; Infection, COVID-19
Establishing Immunogenicity and Safety of Needle-free Intradermal Delivery of mRNA COVID-19 Vaccine
COVID-19 vaccines are limited in supply, especially in low- and middle-income countries, leading to substantial morbidity and mortality.
- Trial name
- MILESTONE (NCT05315362)
- Testing
- solid microneedle skin patch, mRNA-1273, standard needle
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
COVID-19
The PATCH Trial (Prevention And Treatment of COVID-19 With Hydroxychloroquine)
The PATCH trial (Prevention And Treatment of COVID-19 with Hydroxychloroquine) is funded investigator-initiated trial that includes 3 cohorts.
- Trial name
- PATCH (NCT04329923)
- Testing
- Hydroxychloroquine Sulfate 400 mg twice a day, Hydroxychloroquine Sulfate 600 mg twice a day, Hydroxychloroquine Sulfate 600 mg once a day
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ravi Amaravadi, MD
Lung Cancer, Lung; Node
Diagnostic Yeld of Ultrathin Bronchoscopy in Peripheral Pulmonary Lesions
The use of an ultrathin bronchoscope (UB) has recently been introduced in the diagnosis of peripheral lung lesions. The use of the UB can be supported by navigation systems such as fluoroscopy, ultrasound guidance…
- Conditions
- Lung Cancer, Lung; Node, Lung Diseases, Lung TB
- Trial name
- NCT05526573
- Testing
- Ultrathin bronchoscopy (MP190F; Olympus Medical Systems, Tokyo, Japan)
- Where
- 3 sites in Italy
- Volunteers
- 148 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Bronchoscopy
The LUCENT Study - LUng Lesion Assessment Via BF-UCP190F for Central and Extended Nodal Targeting
The Olympus BF-UCP190F bronchoscope combines the reach of a thinner bronchoscope with the benefit of real-time ultrasound, enabling direct lesion visualization and sampling deeper into the lung.
- Trial name
- LUCENT (NCT07253727)
- Testing
- No Interventions
- Volunteers
- 200 people
- Sponsor
- Olympus Europe SE & Co. KG
Pulmonary Mass
CBCT in Guiding Bronchoscopy in Patients With Lung Lesions
This pilot clinical trial studies how well cone-beam computed tomography (CBCT) works in guiding bronchoscopy in patients with lung lesions.
- Trial name
- NCT02978170
- Testing
- Cone-Beam Computed Tomography
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Non-small Cell Lung Cancer Metastatic
K-SAB Trial - Sotorasib Followed by SBRT to 1-3 Lesions in Advanced NSCLC With KRASG12C Mutation
The goal of this interventional study is to learn about the combination of sotorasib and stereotactic radiation therapy (SBRT) in patients with metastatic non-small cell lung cancer (NSCLC) with KRASG12C mutations.
- Trial name
- K-SAB (NCT06127940)
- Testing
- Stereotactic body radiation therapy (SBRT), Temporary Stopping
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska University Hospital
Peripheral Pulmonary Lesions (PPLs), Pulmonary Nodules
Comparative Study of Rotational Cryobiopsy Needle and Automated Biopsy Needle in Transthoracic Biopsy Diagnosing Peripheral Pulmonary Lesions
This study aims to systematically compare the diagnostic efficacy, specimen quality, and complication rates of the cryobiopsy needle technique（CassiII rotational core biopsy） versus the automated biopsy technique in the biopsy of…
- Trial name
- NCT07772479
- Testing
- CassiII rotational core biopsy, Automated biopsy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Chao Yang Hospital
Cancer of the Lung, Lung Cancer
NEUWAVE Flexible Probe Study #2
Patients with medically inoperable and operable secondary soft tissue lesion(s) of the lung will have transbronchial microwave ablation performed using cone beam CT for probe guidance and confirmation.
- Conditions
- Cancer of the Lung, Lung Cancer, Neoplasms, Lung, Carcinoma, Non-Small Cell Lung
- Trial name
- NCT03713099
- Testing
- Microwave ablation
- Where
- 5 sites in United States
- Sponsor
- Ethicon, Inc.
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Peripheral Pulmonary Lesions
Optical Biopsy for Peripheral Pulmonary Lesions
The purpose of the study is to describe confocal laser endomicroscopy (CLE) interpretation criteria for different types of peripheral pulmonary lesions (PPLs), with histopathological correlation, and to perform the validation of…
- Trial name
- NCT06457087
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Non-Small Cell, Lung Infection
Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions
To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with lung lesions.
- Trial name
- NCT06648317
- Testing
- FDG-PET
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Nodule
Tri-modality Sampling Using Radial Probe Endobronchial Ultrasound for the Diagnosis of Peripheral Pulmonary Lesions
As the former radial probe endobronchial ultrasound (RP-EBUS) guided transbronchial forceps biopsy of peripheral pulmonary nodules has some limitations, the purpose of this study is to investigate a novel biopsy technique that…
- Trial name
- NCT06123312
- Testing
- Tri-modality biopsy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Pusan National University Hospital
Lung Cancer
EUS-B-FNA in the Diagnosis of Malignant Parenchymal Lung Lesions
The aim of this study is to evaluate the diagnostic accuracy, safety and tolerability, predictors of success of EUS-B-FNA in the diagnosis of malignant parenchymal lung lesions.
- Trial name
- NCT03983005
- Testing
- EUS-B-FNA
- Where
- 4 sites in Italy
- Volunteers
- 107 people
- Sponsor
- University of Milan
Non-small Cell Lung Cancer
The Continuation of Erlotinib
Newly developed or progressive brain metastasis during erlotinib treatment is considered progressive disease requiring change of treatment regimens despite no progression in extracranial lesions.
- Trial name
- NCT01130779
- Testing
- Erlotinib (TARCEVA®)
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Samsung Medical Center
Covid19, Sars-CoV2
Description of Ophthalmologic Injuries in Intensive Care During the SARS-CoV2 Epidemic - COVID19
The management of patients with SARS-CoV2 in respiratory distress can expose to corneal or retinal lesions induced by the stay in intensive care.
- Trial name
- DOCOV (NCT04385810)
- Testing
- Ophthalmologic exam
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Lung Cancer (NSCLC)
Cryobiopsy Vs. Forceps Biopsy for Peripheral Pulmonary Lesions
This multicenter clinical trial evaluates the diagnostic yields of cryobiopsy and forceps biopsy for peripheral lung nodules. In the cryobiopsy group, cryobiopsy is the primary method, supplemented by forceps biopsy.
- Trial name
- NCT06752395
- Testing
- Transbronchial lung biopsy with radial probe endobronchial ultrasound (Cryobiopsy centered), Transbronchial lung biopsy with radial probe endobronchial ultrasound (Forceps biopsy centered)
- Where
- 3 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Pusan National University Hospital