Clinical trials: Lung Mechanics
Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate
Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation
Chronic obstructive pulmonary disease (COPD) patients often undergo thoracic surgery due to lung cancer and emphysematous changes.
- Conditions
- Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe, Lungcancer
- Trial name
- NCT02962999
- Testing
- Ketamine, Saline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Tracheomalacia, Tracheobronchomalacia
Tracheal Mechanics During Bronchoscopy
The main purpose of this study is use a new type of measurement to help decide what kind of therapy would help people with a collapsing windpipe or tracheomalacia.
- Trial name
- NCT00536315
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy
Effect of Head and Neck Positioning on Lung Sliding in Healthy Volunteers
The goal of this clinical study is to learn how different head-of-bed positions affect lung movement during breathing in healthy adults.
- Trial name
- NCT07351201
- Testing
- Head-of-Bed Elevation
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Diaphragmatic Function, Lung Function
Pulmonary Function Changes and Diaphragmatic Paralysis Following Ultrasound Guided Supraclavicular Brachial Plexus Blockade: The Effects of Decreased Local Anesthetic Volume
This clinical trial is being conducted to study lung function and movement of the major muscle involved in breathing (the diaphragm) after a brachial plexus nerve block (nerve "freezing").
- Trial name
- NCT01048021
- Testing
- Supraclavicular Block
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Anesthesia
Effect of mgso4 on Oxygenation and Lung Mechanics in Morbidly Obese Patients During Bariatric Surgery
The purpose of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery
- Trial name
- NCT04769440
- Testing
- mg sulphate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Obesity, Pulmonary Atelectasis
Effects of PEEP on Heart and Lungs in Obese Subjects
Aim of this study is to better understand pathophysiology of the alteration of respiratory mechanics and cardiovascular function in obese volunteer subjects.
- Conditions
- Obesity, Pulmonary Atelectasis, Obesity Hypoventilation Syndrome, Magnetic Resonance Imaging
- Trial name
- NCT02523352
- Testing
- Non-Invasive Ventilation, Esophageal catheter positioning
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Exercise
Effects of Pilates on Respiratory Mechanics
The aim of this study was to evaluate the influence of a fitness program from the application of Pilates on lung function, thoracoabdominal mobility and respiratory muscle strength in women.
- Trial name
- NCT01841385
- Testing
- Pilates method
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Copd, Muscle Weakness
Mechanical Muscle Proprieties in Patient with COPD
This study aims to determine if patients with Chronic Obstructive Pulmonary Disease (COPD) exhibit altered muscle properties (specifically changes in tone and stiffness) in both their respiratory muscles and skeletal muscles when…
- Conditions
- Copd, Muscle Weakness, Muscle Weakness Condition
- Trial name
- NCT06410950
- Testing
- MyotonPRO Assessment of Muscle Biomechanical Properties
- Where
- Romania
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Asthma
Study to Evaluate the Impact of Obesity on Airway Inflammation and Mechanics in Asthmatics
In the United States there has been a dramatic increase in the number of people who are obese and in the number of people who have asthma. Both are considered serious public health concerns.
- Trial name
- ABI/BALA (NCT00615706)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Emory University
COVID-19
The Prognostic Factors of COVID-19 ARDS Patients and Their Long-term Follow-up of Pulmonary Function Test
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging infectious disease with high transmissibility. Around 20-25% of infected individuals develop severe COVID-19 disease requiring hospitalization and…
- Trial name
- NCT05490914
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
COPD
Complexity of the Airflow in COPD
Recently, there has been a growing interest in the study of nonlinear dynamics as a methodology for complementary analysis to characterize the respiratory pattern. These methods are well established in studies of heart rate.
- Trial name
- NCT01888705
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
COPD, One Lung Ventilation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and hypercapnia may develop.
- Trial name
- NCT02185430
- Testing
- saline infusion, dexmedetomidine infusion
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Oxygenation, Spinal Surgery
Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Pulmonary Mechanics
The bronchodilator effects of volatile anesthetics have been the subject of many clinical studies. It is known that all volatile anesthetics, especially halothane, have similar effects.
- Conditions
- Oxygenation, Spinal Surgery, Sevoflurane, Desflurane
- Trial name
- NCT06118489
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Respiratory Function Impaired
Efficacy of Osteopathic Manipulation on Breathing Mechanics in a Healthy Population: A Randomized Controlled Study
This study focused on improving breathing mechanics by using various osteopathic manipulative therapy (OMT) techniques. The investigators randomly assigned participants to a control group who received sham treatment and a…
- Trial name
- NCT04975542
- Testing
- Osteopathic Manipulative Medicine
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jayla Bostic
Robotic Surgery
Lung Mechanics and Ventilation Efficiency in Robotic Surgery
Robotic surgery requires pneumoperitoneum and specific surgical positioning such as steep Trendelenburg, reverse Trendelenburg, or supine positioning.
- Trial name
- NCT07467135
- Testing
- Intraoperative Mechanical Ventilation Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Acute Lung Injury, ARDS
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
- Trial name
- NCT00143468
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Chronic Obstructive Pulmonary Disease
Pathophysiological Mechanisms of Dyspnea and Activity-limitation in Mild Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a growing cause of death, disability and health care costs in Canada. Nevertheless, COPD remains largely under-diagnosed and under-treated, particularly in its early stages.
- Trial name
- NCT00975403
- Testing
- Dead space breathing, Room air breathing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Severe Asthma
Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation
Eosinophilic inflammation in the small airways of patients with severe asthma is considered to be an important marker of disease severity.
- Trial name
- IMPOSE (NCT05147155)
- Testing
- Mepolizumab
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Healthy, Pulmonary Function Test
Respiratory Oscillometry Norms for Polish Children and Adolescent.
This study aims to establish normative values for respiratory oscillometry in the Polish pediatric population. It is designed as a multicentre, population-based, prospective cohort study including children and adolescents aged…
- Trial name
- OSCILLONiCA-PL (NCT07207720)
- Where
- Poland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Drug Use, Dexmedetomidine
Effect of Dexmedetomidine on Oxygenation and Lung Mechanics
Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when…
- Trial name
- NCT06355960
- Testing
- GROUP Dexmedetomidine, GROUP B, GROUP C
- Where
- Egypt
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Cairo University