Clinical trials: Lung Perfusion
Severe Sepsis, Malaria
Monitoring of Perfusion in Sepsis and Malaria
Sepsis and severe malaria together contribute to an estimated 13 million deaths annually, a great burden of which is in low-income countries.
- Trial name
- PERFuSE (NCT03641534)
- Testing
- Lung Ultrasound examination, Compression ultrasonography (CUS), Echocardiography
- Where
- Bangladesh
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Lung Transplantation
Observational Study on the Clinical Use of ex Vivo Lung Perfusion (XPS™) for Lung Transplantation
Clinical use of ex-vivo perfusion for lung transplantation. Collection, storage and processing of patient data for outcome analysis.
- Trial name
- EVLP XPS (NCT06795516)
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Hannover Medical School
Emphysema
Hypoxic Pulmonary Vasoconstriction Pilot Study
The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction…
- Trial name
- NCT03733470
- Testing
- Sildenafil study group
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Eric A. Hoffman
Mechanical Ventilation, Ventilation Perfusion Mismatch
Post-hoc Analysis of Regional Pulmonary Perfusion and Hemodynamic Parameters Measured by Electrical Impedance Tomography
Define the capability and reliability of the PulmoVista® 500 (PV500) to detect changes in global and regional ventilation and perfusion.
- Trial name
- NCT04249414
- Testing
- PulmoVista 500
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Respiratory Distress Syndrome
Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide
Exogenous bolus surfactant administration may affect hemodynamic parameters and peripheral perfusion. Surfactant therapy is commonly used for respiratory distress syndrome in premature infants, which is also associated with…
- Trial name
- NCT01923844
- Testing
- exogenous surfactant
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ege University
Stereotactic Body Radiotherapy, 68Ga-MAA
Functional Lung Avoidance Planning Guided by Lung Perfusion PET/CT Versus Anatomical Planning for Lung Stereotactic Body Radiotherapy
Stereotactic body radiotherapy (SBRT) has an increasing role in the treatment of both primary and secondary lung tumors. However, lung SBRT remains associated with significant radiation induced lung injury (RILI).
- Conditions
- Stereotactic Body Radiotherapy, 68Ga-MAA, Lung Cancer (Diagnosis)
- Trial name
- Pegasus 2 (NCT07289646)
- Testing
- Conventional anatomical planning radiotherapy, Functional Lung avoidance planning
- Where
- 2 sites in France
- Volunteers
- 418 people
- Sponsor
- University Hospital, Brest
Subarachnoid Hemorrhage
Impact of Early Mobilization on SAH Patients Physiological Parameters
The aim of the study is to evaluate the physiological response to out-of-bed mobilization in patients admitted to the intensive care unit for subarachnoid hemorrhage.
- Trial name
- MOBALPAH (NCT06286683)
- Testing
- lung ultrasound, Transcranial Doppler, near-infrared spectroscopy (NIRS)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Transplantation
OCS Lung System EXPAND II Trial
To evaluate the safety and effectiveness of the OCS™ Lung System to recruit, preserve and assess non-ideal donor lungs that may not meet current standard donor lung acceptance criteria for transplantation.
- Trial name
- NCT03343535
- Testing
- OCS Lung Preservation
- Where
- 14 sites in United States
- Volunteers
- 46 people
- Sponsor
- TransMedics
Lung Cancer, Metastatic Cancer
Paclitaxel and Hyperthermic Perfusion in Treating Patients With Lung Cancer or Lung Metastases That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Heating paclitaxel to several degrees above body temperature and infusing it to the affected area around the…
- Trial name
- NCT00020007
- Testing
- isolated perfusion, paclitaxel, hyperthermia treatment
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Thromboendarterectomy, Pulmonary Embolism and Thrombosis
Assessment of Pulmonary Perfusion and Hemodynamic Measurements by Electrical Impedance Tomography in Patients Undergoing Pulmonary Thromboendarterectomy.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition in which old blood clots block the blood vessels in the lungs, making it harder for the heart to pump blood through the lungs.
- Trial name
- NCT07577700
- Testing
- Electrical Impedance Tomography (EIT)., Pulmonary Perfusion SPECT-CT., Pulmonary Thromboendarterectomy.
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Lung Perfusion, Respiratory Physiology
Effects of Inspiratory vs Expiratory Breath-Hold on Lung Perfusion Measured by EIT Saline Indicator Method: A Self-Controlled Study
This study aims to compare lung perfusion distribution between inspiratory breath-hold and expiratory breath-hold phases using the saline indicator method combined with electrical impedance tomography (EIT).
- Conditions
- Lung Perfusion, Respiratory Physiology, Electrical Impedance Tomography, Ventilation-Perfusion Mismatch
- Trial name
- NCT07303972
- Testing
- Electrical Impedance Tomography Saline Indicator Procedure, Electrical Impedance Tomography Device
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Lung Transplantation
Pharmacokinetics of Imipenem During Ex Vivo Lung Perfusion (EVLP)
Ex vivo lung perfusion (EVLP) is an established strategy to evaluate and optimize high-risk donor lungs that would otherwise be rejected for transplantation mainly due to the presence of edema or infection.
- Trial name
- NCT02670239
- Testing
- normothermic ex vivo lung perfusion
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Pulmonary Arterial Hypertension, Chronic Obstructive Pulmonary Disease
Impact of Inhaled Treprostinil Sodium on Ventilation Perfusion Matching
The purpose of this study is to see how inhaled treprostinil sodium (Tyvaso) affects the amount of air and blood that reach the alveoli, or tiy air sacs, in the lungs of patients with Group 1 Pulmonary Arterial Hypertension with…
- Trial name
- NCT01494896
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Infectious Disease of Lung
Tracheobronchitis in Respiratory Involvement on the Lung SPECT/CT Images of Coronavirus Disease (COVID-19) Patients
Tracheobronchitis signs may be observed on ventilation lung scintigraphy during coronavirus disease (COVID-19) infection. This case report study aimed to analyze the rates and associated factors of such tracheobronchitis in…
- Trial name
- NCT04629222
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Central Hospital, Nancy, France
Left-Hemisphere Stroke
Brain Markers Predicting Reading Recovery After Stroke
For millions of stroke survivors acquired reading deficits represent a significant handicap preventing them from returning to work or continuing their education.
- Trial name
- NCT03845686
- Testing
- Perfusion functional Magnetic Resonance Imaging (perfusion fMRI)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kessler Foundation
Lung Transplant
Novel Lung Trial: Normothermic Ex Vivo Lung Perfusion (Evlp) As An Assessment Of Extended/Marginal Donor Lungs
Human donor lungs that do not meet the standard clinical criteria for donor lung utilization but fit into the study inclusion criteria will be retrieved from the donor using current donor lung retrieval techniques.
- Trial name
- NCT01365429
- Testing
- XPS™ with Steen Solution™
- Where
- 18 sites in United States
- Volunteers
- 252 people
- Sponsor
- XVIVO Perfusion
Non Small Cell Lung Cancer
To Predict Efficacy by Detecting Circulating Endothelial Cell Subsets and Blood Perfusion Parameters Changes in Vivo Tumor in Study of QL1101 and Avastin® in Patients With Non-squamous Non-small Cell Lung Cancer
To reveal changes of peripheral markers and blood perfusion parameters in vivo tumor in the study of QL1101 and Avastin® in patients with Non-squamous Non-small Cell Lung Cancer
- Trial name
- NCT03195569
- Testing
- QL1101, Avastin®, Paclitaxel
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
ARDS
V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by…
- Trial name
- MISMATCHED FR (NCT05578742)
- Testing
- PEEP increase, PEEP decrease
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Nitric Oxide, Acute Respiratory Distress Syndrome
Potential for Inhaled Nitric Oxide and Ventilation-Perfusion Mismatch by Electrical Impedance Tomography in the ARDS Patients With Lung Recruitment
In the recent years, the treatment of Acute Respiratory Distress Syndrome has been proved that lung recruitment re-opens the non-ventilated alveolar to improve ventilation, and inhaled Nitric Oxide dilates non-perfused pulmonary…
- Trial name
- NCT04776408
- Testing
- Lung recruitment combined inhaled Nitric oxide, Lung recruitment
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Lung Transplant
Use of Ex Vivo Lung Perfusion (EVLP) in Reconditioning Marginal Donor Lungs for Transplantation
The overall objective of this study is to evaluate the clinical effectiveness of the novel technique of donor EVLP in increasing lung transplant activity by allowing previously unusable donor lungs to be safely used in clinical…
- Trial name
- EVLP-CHUM (NCT02235610)
- Testing
- EVLP Group
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)