Clinical trials: Lung Protective Ventilation
Acute Respiratory Distress Syndrome
Low-Flow CO2 Removal for Mild to Moderate ARDS With PRISMALUNG
This pilot observational study will assess changes in pH /PaO2 /PaCO2, Respiratory Rate and device CO2 clearance in the first 24 hours of Extracorporeal CO2 removal (ECCO2R) following tidal volume (Vt), and plateau pressure…
- Trial name
- NCT02606240
- Testing
- CO2 removal with PRISMALUNG in ARDS
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Major Abdominal Surgery, Atelectasis
Optimal Interval for Periodic Alveolar Recruitment Maneuvers Achieving 90% Lung Re-expansion During Intraoperative Ventilation
This study aims to determine the optimal interval for periodic alveolar recruitment maneuvers (PARM) that can achieve effective lung re-expansion in 90% of patients undergoing intraoperative mechanical ventilation during…
- Conditions
- Major Abdominal Surgery, Atelectasis, Lung-protective Ventilation, Lung Ultrasound Score
- Trial name
- NCT07239557
- Testing
- Different interval of PARM
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Mechanical Ventilation, Acute Respiratory Distress Syndrome
Ventilation's Parameters Applied in Emergency Medicine. A Prospective Observational Study
To prospectively assess the mechanical ventilation management when its provided by Emergency Physicians in French Hospital, and to assess complications and outcome of these patients.
- Conditions
- Mechanical Ventilation, Acute Respiratory Distress Syndrome, Protective Ventilation, Survival
- Trial name
- PARAVENT (NCT03351920)
- Testing
- mechanical ventilation
- Where
- 7 sites in France
- Volunteers
- 229 people
- Sponsor
- Poitiers University Hospital
Surgery, One-lung Ventilation
Esophageal Pressure Measurements During One-lung Ventilation
The investigators will assess the feasibility and validity of esophageal pressure measurements during one-lung ventilation in the lateral position for surgery by comparing to lung collapse estimated from electrical impedance…
- Trial name
- NCT04725318
- Testing
- One-lung ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
ARDS, Acute Respiratory Failure
Generating Evidence in ECMO Ventilation Strategies
The goal of this pilot clinical trial is to test if ICU level ventilator protocols are appropriate interventions to study differences in ventilator strategies for patients with acute respiratory failure supported by VV-ECMO.
- Trial name
- GENIE-Vent (NCT05708365)
- Testing
- Standard-Lung Protective Ventilation, Ultra-Lung Protective Ventilation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Lung Diseases
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications.
- Trial name
- I-PEEP-THO (NCT05525312)
- Testing
- "Open-lung" protective ventilation strategy, "Standard" protective ventilation strategy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Mechanical Ventilation, Ventilator-associated Conditions
ED Lung Protective Ventilation to Reduce Complications
Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS).
- Conditions
- Mechanical Ventilation, Ventilator-associated Conditions, ARDS
- Trial name
- NCT02543554
- Testing
- lung protective ventilation
- Where
- United States
- Volunteers
- 1,705 people
- Sponsor
- Washington University School of Medicine
ARDS, Human
Decrease of Lesions Induced by Mechanical Ventilation During ARDS
Modification of mechanically ventilated lesions by an ultra-protective multimodal strategy compared to a protective strategy in patients with veno-venous ECMO for severe ARDS.
- Trial name
- ECMO-VILI (NCT03918603)
- Testing
- ventral décubitus
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pulmonary Complications, Inflammatory Response
Intraoperative PEEP Optimization: Effects on Postoperative Pulmonary Complications and Inflammatory Response
The purpose of this prospective randomized controlled trial is to determine the effects of intraoperative lung protective mechanical ventilation using an individual optimal PEEP value on postoperative pulmonary complications and…
- Trial name
- NCT02931409
- Testing
- Optimal PEEP, Standard PEEP
- Where
- 2 sites in Hungary
- Volunteers
- 40 people
- Sponsor
- Péterfy Sándor Hospital
ARDS, Human, Mechanical Ventilation Pressure High
Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist
The aim of this study is to investigate the use neurally adjusted ventilatory assist (NAVA) as lung protective strategy in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NAVA (NCT03868982)
- Testing
- Neurally adjusted ventilatory assist
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University
Ventilator-Induced Lung Injury, Mechanical Ventilation Complication
Protective Mechanical Ventilation and Risk of Postoperative Complications in Abdominal Surgery
Randomized controlled trial, comparing two groups of 40 patients each scheduled for open major abdominal surgery. The intervention group was ventilated with a protective strategy consisting on a low Tidal volume (Vt) (6ml/kg of…
- Conditions
- Ventilator-Induced Lung Injury, Mechanical Ventilation Complication, Postoperative Complications
- Trial name
- NCT03165760
- Testing
- protective ventilation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mongi Slim Hospital
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Coronavirus Infection, Ventilatory Failure
To Compare Videolaryngoscope Against Direct Laryngoscope for Intubation When Powered Air Purifying Respirator is Worn
Various guidelines for endotracheal intubation (insertion of breathing tube for mechanical ventilation) of Coronavirus Disease 2019 (COVID-19) patients recommend the use of videolaryngoscope (medical device used for intubation…
- Conditions
- Coronavirus Infection, Ventilatory Failure, Anesthesia Intubation Complication
- Trial name
- NCT04424953
- Testing
- McGrath videolaryngoscope, Direct laryngoscope
- Where
- Singapore
- Volunteers
- 28 people
- Sponsor
- Singapore General Hospital
Ventilator-induced Lung Injury
Intraoperative Lung-Protective Ventilation in Neurosurgery
The purpose of this study is to explore the effectiveness of lung-protective ventilation during general anesthesia for neurosurgical procedures on postoperative pulmonary outcome, compared with traditional ventilation.
- Trial name
- NCT02386683
- Testing
- lung-protective ventilation
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Capital Medical University
Mechanical Ventilation Complication, Mechanical Power
LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU
Prospective, observational, longitudinal study, September 2019 to March 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras, Coahuila.
- Conditions
- Mechanical Ventilation Complication, Mechanical Power, Driving Pressure, Lung Protective Ventilation
- Trial name
- LUMEDRI-MORT (NCT04193254)
- Where
- Mexico
- Volunteers
- 63 people
- Sponsor
- JOSE IVAN RODRIGUEZ DE MOLINA SERRANO
Adult Respiratory Distress Syndrome
Protective Ventilation With Carbon Dioxide (CO2) -Removal Technique in Patients With Adult Respiratory Distress Syndrome (ARDS)
30% of ARDS patients ventilated according to NIH protocol presents morphological (CT) and functional (Stress Index>1) conditions of hyperinflation even with Plateau pressure (Pplat) < 30 cmH2O; values of Pplat lower than 26 cmH2O…
- Trial name
- NCT00465309
- Testing
- protective ventilation with CO2 removal technique
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Pulmonary Complication
Lung Protective Ventilation During Pulmonary Lobectomy in Children
The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in pediatric patients.
- Trial name
- NCT02680925
- Testing
- lung protective ventilation, Conventional ventilation
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Seoul National University Hospital
Respiration
Lung Protective Ventilation Strategies
Obesity is becoming a common condition and bariatric metabolic surgery is one of the main options for treating morbid obesity. However, since most patients undergoing robotic bariatric surgery are class III obese, it brings new…
- Trial name
- NCT06247943
- Testing
- Lung Protective Ventilation Strategy, regular ventilation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Tianjin Medical University General Hospital
Oxygenation, Driving Pressure
Clinical Impact of Different Duration Prone Postition Treatment for Patients With ARDS.
Acute respiratory distress syndrome (ARDS) is a life-threatening disease, patients with ARDS usually need mechanical ventilation.
- Trial name
- NCT04391387
- Testing
- prone position
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Acute Respiratory Distress Syndrome (ARDS)
The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial
What is the effect of early high frequency oscillation (HFO) versus a lung-protective conventional ventilation (CV) strategy (using HFO only as rescue therapy), on all-cause hospital mortality among patients with severe early…
- Trial name
- OSCILLATE (NCT01506401)
- Testing
- SensorMedics 3100B High Frequency Oscillatory Ventilator, Lung Protective Ventilation
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 548 people
- Sponsor
- Canadian Critical Care Trials Group