Clinical trials: Lymph Node
Supraglottic Cancer
Radiotherapy vs Neck Dissection for Clinical T1/2N0 Supraglottic Cancer
Supraglottic cancer is a main type of laryngeal carcinoma, which is one of the most common head and neck tumors. Cervical nodal metastasis is an important prognostic factor in supraglottic cancer.
- Trial name
- NCT03358602
- Testing
- Radiotherapy, Selective neck dissection
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Neoplasms, Fluorescence
Fluorescence Laparoscopic Navigation for Rectal Cancer and Sigmoid Colon Cancer
To explore the short-term and long-term outcomes of fluorescence laparoscopic navigation D2 lymph node dissection for colorectal cancer surgery by comparing it with D3 lymph node dissection.
- Conditions
- Colorectal Neoplasms, Fluorescence, Lymph Node Excision
- Trial name
- FLORA-01 (NCT05730595)
- Testing
- lymph node dissection
- Where
- 19 sites in China
- Volunteers
- 550 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Cutaneous Squamous Cell Carcinoma of the Head and Neck
Surveillance of Regional Nodal Basins in Patients With Primary High Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck
In this prospective cohort study, investigators will conduct ultrasound surveillance of the nodal basins of patients with head and neck cutaneous squamous cell carcinoma (cSCC) whose tumors are considered high risk and staged by…
- Trial name
- NCT05956795
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Vulvar Cancer Stage I, Vulvar Cancer Stage II
A Phase III Randomised Clinical Trial of Ultrasound Groin Monitoring Versus Groin Lymph Node Dissection to De-Escalate the Extent of Surgery in Vulvar Cancer
This study is a phase III, open label, multicentre, three-group, randomised clinical trial. The primary aim of this study is to determine whether intensive groin ultrasound monitoring (1) is effective and safe to replace invasive…
- Conditions
- Vulvar Cancer Stage I, Vulvar Cancer Stage II, Lymph Node Metastasis, Groin Node
- Trial name
- ANVU (NCT06476639)
- Testing
- High-resolution bilateral groin ultrasound monitoring
- Where
- 9 sites in Australia
- Volunteers
- 640 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Breast Cancer, Node-positive Breast Cancer
TAD in Primary Breast Cancer With Initially ≥ 3 Suspicious Lymph Nodes
Due to high pathological complete remission (pCR) rates in both breast and lymph nodes (ypT0/Tis, ypN0) following neoadjuvant systemic therapy (NST) in many patients with initially clinically node-positive (cN+) breast cancer…
- Trial name
- SenTa2 (NCT05462457)
- Testing
- Targeted axilllary dissection (TAD) followed by axillary lymph node dissection (ALND)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Kliniken Essen-Mitte
Stage IA Skin Melanoma, Stage IB Skin Melanoma
Recombinant Interferon Alfa-2b in Treating Patients With Melanoma
This pilot clinical trial studies recombinant interferon alfa-2b in treating patients with melanoma. Recombinant interferon alfa-2b may interfere with the growth of tumor cells and slow the growth of melanoma
- Conditions
- Stage IA Skin Melanoma, Stage IB Skin Melanoma, Stage IIA Skin Melanoma, Stage IIB Skin Melanoma
- Trial name
- NCT01460875
- Testing
- recombinant interferon alfa-2b, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- William Carson
Neuroendocrine Tumors, Small Intestinal NET
Preoperative Imaging in Patients With Small Bowel Neuroendocrine Tumors
Digestive NETs are the second most common malignant digestive tumor after adenocarcinoma. The most common gastrointestinal NETs arise from the small intestine.
- Conditions
- Neuroendocrine Tumors, Small Intestinal NET, Lymph Node Metastasis
- Trial name
- TEGRELE (NCT05246319)
- Testing
- preoperative imaging
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Laurent BRUNAUD
Endometrial Cancer
Lymph Node Counts in Endometrial Cancer Staging
The purposes of this study are to determine whether total lymph node count or the percentage of identified nodes with metastatic disease are influenced by (1) the method of categorizing tissue specimens or (2) the techniques of…
- Trial name
- NCT02335775
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Uterine Neoplasms, Cervix Neoplasms
Combidex USPIO - Ultra-small Superparamagnetic Iron Oxide
The purpose of this study is to test whether or not a new contrast agent called Combidex, a contrast agent formulated from ultra-small superparamagnetic iron oxide (USPIO) improves the ability of Magnetic Resonance Imaging (MRI)…
- Conditions
- Uterine Neoplasms, Cervix Neoplasms, Bladder Neoplasms, Prostatic Neoplasms
- Trial name
- NCT00188695
- Testing
- MRI contrast agent Combidex (ferumoxtran-10)
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University Health Network, Toronto
Cancer of the Head and Neck
Positronic Emission Tomography (PET) Imaging in Post Radiation Evaluation of Head and Neck Tumours (PET PREVENT Trial)
The purpose of this trial is to determine the ability of positron emission tomography (PET) to detect residual cancer in neck lymph nodes of patients following curative treatment with radiation therapy for squamous cell cancer…
- Trial name
- NCT00147472
- Testing
- PET scan in addition to conventional CT imaging
- Where
- 4 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8
Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial
This phase II trial studies how well personalized neck radiation therapy directed by sentinel lymph node biopsy (SLNB) works in treating patients with oral cavity squamous cell carcinoma (OCSCC).
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8, Stage II Lip and Oral Cavity Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8
- Trial name
- NCT07121595
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan Rogel Cancer Center
Prostate Cancer
Choline PET/CT vs. Dual Time Point FDG PET/CT in Prostate Cancer
Prostate cancer is currently the leading newly diagnosed cancer in the industrialized world. Treatment of prostate cancer is highly dependent on the stage of the disease.
- Trial name
- NCT02232724
- Testing
- Choline PET/CT and Dual time point FDG PET/CT
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Papillary Thyroid Cancer, Lymph Node Metastases
Precision Thyroid Cancer Surgery With Molecular Fluorescent Guided Imaging
Almost 50 % of papillary thyroid cancer (PTC) patients have central lymph node metastases (CLNM), which are associated with a high risk of persistent or recurrent disease.
- Trial name
- TARGET (NCT03470259)
- Testing
- IV adminstration of EMI-137, Multispectral Fluorescence Reflectance Imaging, Spectroscopy
- Where
- 2 sites in Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Refusal of Breast Surgery in Patients With Breast Cancer With a cCR After NST and a Confirmed Pathological Complete Response (pCR) Using VAB and SLNB
Refusal of Breast Surgery in Patients With Breast Cancer With a Clinical Complete Response (cCR) After Neoadjuvant Systemic Therapy and a Confirmed Pathological Complete Response (pCR) Using Vacuum-assisted Biopsy (VAB) and Sentinel Lymph Node Biopsy (SLNB)
The main goal of the study is to abandon breast surgery in patients with breast cancer with a clinical complete response (cCR) after neoadjuvant systemic therapy and confirmed pCR using Vacuum-assisted biopsy (VAB) and sentinel…
- Trial name
- VAB (NCT04293796)
- Testing
- Vacuum-assisted biopsy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Breast Neoplasms
Comparison of Two Types of Biopsy in Suspicious Axillary Lymph Nodes
Axillary lymph node status is a vital prognostic factor in breast cancer patients and provides crucial information for making treatment decisions.
- Trial name
- NCT03130946
- Testing
- Cryo-assisted core needle biopsy, FNA
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Peking University People's Hospital
Gastrectomy for Gastric Cancer
Lymph Node Staging System With a Novel Concept for Gastric Cancer: a Hybrid Type of Topographic and Numeric Ones
For staging the status of lymph node metastasis in gastric cancer, typographic based staging system was applied until last decade, especially in Eastern countries.
- Trial name
- NCT01961791
- Testing
- gastrectomy
- Where
- South Korea
- Volunteers
- 6,025 people
- Sponsor
- Yonsei University
Papillary Thyroid Cancer, Lymph Node Metastasis
Frozen Section-Guided Selective Ipsilateral Central Neck Dissection in Bethesda V-VI Thyroid Nodules
The goal of this observational pilot cohort study is to evaluate the feasibility and clinical implications of frozen section analysis-guided selective ipsilateral central neck dissection in adult patients undergoing primary…
- Trial name
- NCT07659717
- Testing
- Frozen section analysis (FSA)
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Eleonora Lori, MD
Breast Cancer
Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer Patients
This study aimed to compare detection rate between dual sentinel node staining method using mixture of indocyanine green (ICG) with radioisotope(RI), and RI only.
- Trial name
- NCT02479997
- Testing
- Indocyanine green, Radioisotope
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- National Cancer Center, Korea
Sentinel Lymph Node Biopsy, Locoregional Neoplasm Recurrence
SLNB After Neoadjuvant Treatment in Node Positive Patients
From May 2016 till May 2018 all breast cancer patients with operable disease submitted to surgery after neoadjuvant treatment would be divided in four groups considering initially clinical axillary stage, axillary procedure that…
- Conditions
- Sentinel Lymph Node Biopsy, Locoregional Neoplasm Recurrence, Progression, Disease
- Trial name
- NCT03833960
- Volunteers
- 65 people
- Sponsor
- Clinical Hospital Center Rijeka
Sentinel Lymph Node Biopsy, Breast Cancer
Tilmanocept vs Sulfur Colloid in Sentinel Lymph Node Biopsy
A randomized controlled double-blinded study comparing the intraoperative injection of lymphatic mapping agents Tc 99m tilmanocept to Tc 99m filtered sulfur colloid in breast cancer patients undergoing breast conservation and…
- Trial name
- NCT03199560
- Testing
- Tc 99m tilmanocept, Tc 99m filtered sulfur colloid
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Memorial Health University Medical Center
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