Clinical trials: Lymph Node
Stomach Neoplasms
Robotic Total Gastrectomy for Locally Advanced Proximal Gastric Cancer
The purpose of this study is to explore the clinical Efficacy of robotic assisted spleen-preserving No. 10 lymph node dissection for patients with locally advanced upper third gastric adenocarcinoma（cT2-4a, N-/+, M0）.
- Trial name
- NCT03524287
- Testing
- Robotic Assisted No.10 Lymph Node Dissections
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fujian Medical University
Colorectal Cancer Stage 0, Colorectal Cancer Stage I
Matrilysin Expression in Different Stages of Colorectal Tumors
Matrix metalloproteinases (MMPs) have been shown to be involved in cancer biology. Significant expression of MMP-7 (matrilysin) in colorectal cancer is mainly associated with metastatic disease even though it is expressed in most…
- Conditions
- Colorectal Cancer Stage 0, Colorectal Cancer Stage I, Colorectal Cancer Stage II, Colorectal Cancer Stage III
- Trial name
- MMP7 (NCT01570452)
- Testing
- colonic or colorectal resection
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Head and Neck Cancer, Lymphoma
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
- Conditions
- Head and Neck Cancer, Lymphoma, Lymph Node Metastasis
- Trial name
- NCT05754814
- Testing
- Malignant lymph nodes
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bladder Cancer
A 12-Gene Blood-Based Signature for Detecting Metastatic Bladder Cancer
The purposes of this study is to evaluate a new genetic-based test which will identify patients diagnosed with muscle-invasive bladder cancer before their surgery, who might have specific genes, which will increase their chances…
- Trial name
- NCT00918008
- Testing
- Blood draw
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Uterine Cervical Neoplasms
Sentinel Lymph Node Mapping In Cervical Cancer
Lymph node assessment provides the crucial information about the prognosis of cervical cancer. Sentinel lymph node stands in the first station on the lymph node metastasis pathways.
- Trial name
- SLNMICC (NCT03778268)
- Testing
- sentinel lymph node biopsy
- Where
- 2 sites in China
- Volunteers
- 1,143 people
- Sponsor
- Peking University People's Hospital
Micrometastases, Neoadjuvant Chemotherapy
Micrometastases in Axillary Lymph Nodes in Breast Cancer, Post-neoadjuvant Chemotherapy
This study aims to investigate the significance of minimal residual axillary disease following NAC, with a particular focus on micrometastases (ypNmi), in comparison to pathologic lymph node-negative (ypN0) or macrometastases…
- Trial name
- NCT06149884
- Testing
- Sentinel lymph node biopsy, axillary lymph node dissection
- Volunteers
- 978 people
- Sponsor
- Gangnam Severance Hospital
Lung Lesions, Mediastinal and Hilar Lymph Node Enlargement
A Study of Contrast-enhanced EBUS in Lung Lesions and Intrathoracic Lymph Nodes
Exploring the Clinical Application Value of Contrast Enhancement Features in CE-EBUS Images for the Diagnosis of Pulmonary Lesions and Intrapulmonary Lymph Nodes
- Trial name
- NCT07060378
- Testing
- Contrast-enhanced endobronchial ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Breast Cancer
Lymph Node Identification Using Magtrace and Magseed Before Chemotherapy
Magnetic tracer injected before preoperative chemotherapy in breast cancer patients for sentinel lymph node detection. Also, magnetic tracer in combination with magnetic clip for index node identification.
- Trial name
- SentiNeo2 (NCT06104371)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 459 people
- Sponsor
- Vastra Gotaland Region
Clear Cell Renal Cell Carcinoma, Metastatic Malignant Neoplasm in the Bone
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study
This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with…
- Conditions
- Clear Cell Renal Cell Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lymph Nodes, Metastatic Malignant Neoplasm in the Soft Tissue
- Trial name
- NCT03793166
- Testing
- Biospecimen Collection, Bone Scan, Cabozantinib
- Where
- 859 sites in United States, Puerto Rico
- Volunteers
- 1,175 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Vulvar Cancers
The Effect of Dose and Storage Conditions of Indocyanine Green on Efficacy and Cost in Sentinel Lymph Node Mapping in Gynecological Cancer
This research will determine the impact of optimizing dosage and storage conditions for indocyanine green on health outcomes and will contribute to improving treatment processes in gynecological cancers.
- Conditions
- Endometrial Cancer, Vulvar Cancers, Cervical Cancer, Indocyanine Green (ICG)
- Trial name
- DOSTCONICG (NCT07380698)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cukurova University
Vulvar Cancer Stage I, Vulvar Cancer Stage II
A Phase III Randomised Clinical Trial of Ultrasound Groin Monitoring Versus Groin Lymph Node Dissection to De-Escalate the Extent of Surgery in Vulvar Cancer
This study is a phase III, open label, multicentre, three-group, randomised clinical trial. The primary aim of this study is to determine whether intensive groin ultrasound monitoring (1) is effective and safe to replace invasive…
- Conditions
- Vulvar Cancer Stage I, Vulvar Cancer Stage II, Lymph Node Metastasis, Groin Node
- Trial name
- ANVU (NCT06476639)
- Testing
- High-resolution bilateral groin ultrasound monitoring
- Where
- 9 sites in Australia
- Volunteers
- 640 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Neoplasm of Mediastinal Lymph Nodes
Predicting Malignancy Using Endoluminal Ultrasound Characteristics in Mediastinal Lymph Nodes
There is no single method to investigate mediastinal LN invasion. Hence, a patient may have to undergo several tests and procedures. Noninvasive and invasive approaches are employed.
- Trial name
- CT0024 (NCT01329575)
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Nipple-sparing Mastectomy, Prophylactic Mastectomy
Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy
Nipple-sparing mastectomy (NSM) is indicated for breast cancer requiring total mastectomy and without nipple involvement by cancer.
- Conditions
- Nipple-sparing Mastectomy, Prophylactic Mastectomy, Breast Cancer, BRCA1 Mutation
- Trial name
- NCT05448963
- Testing
- da Vinci SPⓇ Single-port System
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Early Gastric Cancer, Gastric Adenocarcinoma
Early Gastric Cancer in the Spanish EURECCA Registry
Early gastric cancer (EGC) is increasingly diagnosed in Western countries; however, important differences remain with Eastern populations regarding staging accuracy, treatment strategies, and the risk of lymph node metastasis.
- Trial name
- NCT07781319
- Volunteers
- 600 people
- Sponsor
- Corporacion Parc Tauli
Response To Dengue Exposure
Trial to Model Primary, Secondary, and Tertiary Dengue Using a Monovalent Vaccine
Background: Dengue is a disease caused by a virus transmitted by mosquitoes in tropical and subtropical regions. Dengue is a leading cause of hospital stays and death in parts of Asia and Latin America, and outbreaks have…
- Trial name
- NCT05691530
- Testing
- rDEN3Δ30/31-7164
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Vulvar Cancer
Ultrasound Morphometric and Cyto/Histological Combined Pre-operative Assessment of Inguinal Lymph Node Status in Women With Invasive Vulvar Carcinoma
Vulvar cancer is a rare and very aggressive cancer, mainly spreading through lymphatics, in which the preoperative evaluation is critical to address surgery between sentinel node biopsy or radical groin lymphadenectomy.
- Trial name
- Morpho-Node (NCT02988765)
- Testing
- Groin ultrasound +/- fine needle aspiration
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Catholic University of the Sacred Heart
Gynecologic Cancer
Laparoscopic Ultra-radical Lymph Node Debulking Using Yasargil Clamps (Yasargil-1)
Although several studies have demonstrated the overall benefits of a laparoscopic approach for pelvic and para-aortic lymphadenectomy, complications remain a challenging scenario.
- Trial name
- NCT05318170
- Testing
- Laparoscopic ultra-radical lymph node debulking
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Palermo
Endometrial Cancer
Pilot Study Using a PET Gamma Probe to Evaluate Lymph Nodes in Endometrial Cancer
The surgical management of high-risk endometrial cancer often involves an extensive operation to remove lymph nodes as sites of possible cancer spread.
- Trial name
- NCT01467219
- Testing
- lymphadenectomy, therapeutic conventional therapy, Positron Emission Tomography/ Computed Tomography
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Non-small Cell Lung Cancer
Preoperative Chemoradiotherapy Versus Chemotherapy Alone in Nonsmall Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases
The main objective of this trial is to compare feasibility and efficacy of sequential neoadjuvant chemoradiotherapy with 44Gy concomitant boost to neoadjuvant chemotherapy alone.
- Trial name
- NCT01187290
- Testing
- neoadjuvant chemoradiotherapy
- Volunteers
- 80 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Breast Cancer
Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Letrozole may fight breast cancer by lowering the amount of estrogen the body makes.
- Trial name
- SOLE (NCT00553410)
- Testing
- Letrozole
- Where
- 164 sites in United States, Australia and 18 more
- Volunteers
- 4,884 people
- Sponsor
- ETOP IBCSG Partners Foundation
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