Clinical trials: Lymph Node
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
D2 Gastrectomy With or Without Para-Aortic Lymph Node Dissection After Chemoimmunotherapy for Gastric Cancer
Some patients with gastric cancer have enlarged para-aortic lymph nodes, also called No. 16 lymph nodes, at diagnosis. After standard chemoimmunotherapy, these lymph nodes may shrink to less than 10 mm on imaging, but it is…
- Trial name
- PAN-SELECT (NCT07912606)
- Testing
- Gastrectomy with D2 lymphadenectomy plus para-aortic lymph node dissection, Gastrectomy with standard D2 lymphadenectomy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cancer of the Urinary Tract
Merits of Performing a Modified Template Retroperitoneal Lymph Node Dissection
The primary objective is to show that performing a lymph node dissection may detect occult nodal metastasis in this patient population whereby providing important diagnostic information, with potential therapeutic benefits in…
- Trial name
- NCT00751140
- Testing
- Lymph Node Dissection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Esophageal Squamous Cell Carcinoma
Involved Field Irradiation (IFI) Versus Elective Nodal Irradiation (ENI) for Esophageal Cancer
This study examines contrast advantages and disadvantages of elective or prophylactic nodal irradiation in the treatment of esophageal cancer with three-dimensional conformed radiotherapy.
- Trial name
- NCT01551589
- Testing
- Involved Field Irradiation(IFI), docetaxel and cisplatin, Elective Nodal Irradiation (ENI)
- Where
- 4 sites in China
- Volunteers
- 220 people
- Sponsor
- Chengya Chou
Gastric Cancer, Surgery
Indocyanine Green Tracer Using in Laparoscopic Radical Gastrectomy for Locally Advanced Gastric Cancer
Patients with locally advanced gastric adenocarcinoma (CT2-4a N0/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph…
- Trial name
- CLASS-11 (NCT04593615)
- Testing
- ICG near-infrared imaging
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- Fujian Medical University
The Malignant Lesions and Non-malignant Lesions of Pancreas, Bile Duct, Liver and Lymph Node
An Artificial Intelligence System for ROSE of EUS-FNA Sample: a Prospective, Multicenter, Diagnostic Study.
This is an observational study with a prospective, multicenter, disgnostic design. An artificial intelligence system named ROSE-AI system was developed using cytopathological slide images taken by microscope camera or smartphone…
- Trial name
- ROSE，EUS-FNA (NCT06718725)
- Testing
- ROSE-AI system
- Where
- China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Splenic Hilum Lymph Nodes Dissection
3D Versus 2D Laparoscopic Total Gastrectomy With Splenic Hilum Lymph Nodes Dissection
The investigators will perform a prospective randomized comparison between 3D and 2D laparoscopic total gastrectomy with splenic hilum lymph nodes dissection.
- Trial name
- NCT02984787
- Testing
- 3D Laparoscopic total gastrectomy, 2D Laparoscopic total gastrectomy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Chinese PLA General Hospital
Cancer of Lymph Node
Clinical and Technical Feasibility of a Ultrasuperparamagnetic Nanoparticle Iron Oxide (USPIO)-Enhanced Magnetic Resonance Lymph Node Imaging
The goal of this clinical research study is to learn if the drug Feraheme ® (ferumoxytole) helps researchers most clearly to "see" cancerous lymph nodes on an MRI scan.
- Trial name
- NCT01815333
- Testing
- Feraheme, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Testicular Cancer
A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases
Testicular cancer represents 1% of adult neoplasms and is the most common solid malignancy in young men. At diagnosis, approximately 90% of cases are germ cell tumours (GCT), categorised as either seminoma (55-60%) or…
- Trial name
- RPLND-Seminoma (NCT06932458)
- Testing
- Retroperitoneal Lymph Node Dissection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Breast Cancer
Response-Based Local Therapy for Regionally Advanced Breast Cancer
The goal of this interventional clinical trial is to evaluate if an individualized treatment strategy (involving radiation boost, surgery, and systemic consolidation) can improve progression-free survival in patients with breast…
- Trial name
- NCT07376538
- Testing
- Response-adapted comprehensive treatment strategy
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Lymphadenopathy
Comparison of Endobronchial Ultrasound-Guided Biopsy Using Fine Needle Aspiration Versus Fine Needle Capillary Sampling
Primary objective: To estimate the degree of agreement in diagnosis of cytologic samples from mediastinal lymph nodes obtained by Endobronchial Ultrasound (EBUS)-guided Fine Needle Capillary Sampling (FNC) versus Fine Needle…
- Trial name
- NCT00886847
- Testing
- Lymph Node Needle Tissue Collections
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections
A Study on the Effect of Chemotherapy Combined With Anti-HIV Drugs in HIV-Positive Patients
The purpose of this study is to determine the safety of anti-HIV drugs combined with low-dose chemotherapy (consisting of cyclophosphamide [CTX]) in HIV-positive patients.
- Trial name
- NCT00000899
- Testing
- Nelfinavir mesylate, Lamivudine, Filgrastim
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Prostate Cancer
Samarium-153 With Neoadjuvant Hormonal and Radiation Therapy for Locally Advanced Prostate Cancer
The purpose of this study is to determine the safety and effectiveness of Samarium-153 when given in combination with hormonal and external beam radiation therapy in men with high risk prostate cancer.
- Trial name
- NCT00328614
- Testing
- Samarium-153, Total Androgen Suppression (TAS) with Bicalutamide, Total androgen suppression (TAS) with Goserelin Acetate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Papillary Thyroid Carcinoma
Deep Learning-Based Intraoperative Dual-tracer Video Analysis of Sentinel Lymph Node Mapping for Metastasis Prediction in cN0 Papillary Thyroid Carcinoma
The goal of this observational study is to learn if a computer program (deep learning) can accurately predict lymph node spread in adults with papillary thyroid cancer who have no signs of lymph node involvement before surgery…
- Trial name
- NCT07391514
- Testing
- Indocyanine green (ICG) sentinel lymph node mapping, Carbon nanoparticle (CNs) sentinel lymph node mapping, Dual-tracer (ICG combined with CNs) sentinel lymph node mapping
- Where
- China
- Volunteers
- 131 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Lymph Node Resection
Use of Tachosil® for Lymph Sealing During Surgery
The purpose of this study is to describe effectiveness and reliability of TachoSil® in lymph sealing after lymphadenectomy.
- Trial name
- SEAL (NCT01920958)
- Testing
- TachoSil®
- Where
- Germany
- Volunteers
- 233 people
- Sponsor
- Takeda
Breast Cancer
Application of Rapid On-site Evaluation in Lymph Node Biopsy of Breast Cancer
The goal of this clinical trial is to evaluate the value of rapid on-site evaluation（ROSE） in lymph node biopsy of breast cancer.
- Trial name
- NCT06495736
- Testing
- Experimental: ROSE technique stain
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yunnan Cancer Hospital
Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus
Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.
- Conditions
- Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling, Prognosis
- Trial name
- NCT04276532
- Testing
- sentinel lymph node sampling (SLN), pelvic lymphonodectomy (PLN)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Xiaojun Chen
Breast Cancer
MR-guided RAdiotherapy to Breast With Dose Escalation to regionaL Lymph NodEs
Radiotherapy to the breast and lymph nodes is routinely planned using CT scans. The introduction of magnetic resonance imaging (MRI) has the potential to better visualise the lymph nodes and so define a smaller treatment area or…
- Trial name
- MIRABELLE (NCT03405519)
- Testing
- Radiotherapy planning using both CT and MRI scans
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Sentinel Lymph Node, Superficial Uterine Vein
Correlation of Pelvic Sentinel Lymph Node With Superficial Vein
Pelvic Sentinel Lymph Node (SLN) biopsy is an important integral part of endometrial surgery. Although SLN is usually found on internal iliac artery, location is variable.
- Conditions
- Sentinel Lymph Node, Superficial Uterine Vein, Deep Uterine Vein
- Trial name
- NCT06741007
- Testing
- Retroperitoneal pelvic lymphatic and uterine vessel dissection
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Esophageal Squamous Cell Carcinoma (ESCC)
Postoperative Radiotherapy and Lymph Node Dissection After Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma
This is a multicenter, retrospective observational study using existing medical records of patients with esophageal squamous cell carcinoma who received at least two cycles of neoadjuvant immunochemotherapy followed by curative…
- Trial name
- NCT07705412
- Testing
- Postoperative Radiotherapy, Lymph Node Dissection
- Where
- China
- Volunteers
- 465 people
- Sponsor
- Tongji Hospital
Squamous Cell Carcinoma of Head and Neck
Dose De-escalation and Sentinel LN Mapping Driven Radiotherapy of Contralateral Neck in Ipsilateral Node Positive HNSCC
The study involves head and neck squamous cell carcinomas (HNSCC) of the oral cavity, oropharynx, larynx or hypopharynx with positive nodes on only one side of the neck and no distant metastasis treated by primary…
- Trial name
- SEMIRAHN (NCT04688528)
- Testing
- Dose de-escalation and / or Volume de-escalation
- Where
- 10 sites in Belgium
- Volunteers
- 147 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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