Clinical trials: Lymph Node
Rectal Cancer
Lateral Lymph Node Dissection for Middle-low Rectal Cancer
The investigators will perform CT three-dimension reconstruction for middle-low rectal cancer patients who have enlarged lateral lymph nodes to recognize the variance of pelvic vessels, by which to help reduce operative time and…
- Trial name
- NCT03826862
- Testing
- CT three-dimensional reconstruction
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ziqiang Wang,MD
Brachytherapy, Squamous Cell Carcinomas
RISI in the Treatment of Recurrent Metastatic SCC of Thoracic Inlet Lymph Nodes
The malignant tumor at the thoracic entrance is difficult to be surgically removed, and radiotherapy or radiotherapy based comprehensive treatment is often chosen at the initial diagnosis.
- Trial name
- NCT04266327
- Testing
- 3D-printing Template-assisted CT-guided I-125 Seed Implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Lung Cancer, Lymph Node Metastasis
Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist.
- Conditions
- Lung Cancer, Lymph Node Metastasis, Pathologic Processes
- Trial name
- NCT06252129
- Testing
- Subjects undergoing a lung specimen lymph node dissection, Control group
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Thyroid Cancer, Thyroidectomy With Central Lymph Node Dissection
Does Parathyroid Autofluorescence Reduces Unintensional Parathyroidectomy During Total Thyroidectomy With Central Lymph Node Compartment Dissection
The aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy with central lymph node compartment dissection.
- Trial name
- FLUOBCC (NCT04339478)
- Where
- 2 sites in Greece, Jordan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Refusal of Breast Surgery in Patients With Breast Cancer With a cCR After NST and a Confirmed Pathological Complete Response (pCR) Using VAB and SLNB
Refusal of Breast Surgery in Patients With Breast Cancer With a Clinical Complete Response (cCR) After Neoadjuvant Systemic Therapy and a Confirmed Pathological Complete Response (pCR) Using Vacuum-assisted Biopsy (VAB) and Sentinel Lymph Node Biopsy (SLNB)
The main goal of the study is to abandon breast surgery in patients with breast cancer with a clinical complete response (cCR) after neoadjuvant systemic therapy and confirmed pCR using Vacuum-assisted biopsy (VAB) and sentinel…
- Trial name
- VAB (NCT04293796)
- Testing
- Vacuum-assisted biopsy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Pancreatic Cyst, Pancreatic Neoplasms
Clinical Evaluation Of Needle-based Confocal Laser Endomicroscopy in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas
This study focuses on three different lesions: pancreatic cysts, lymph nodes near the gastrointestinal tract and pancreatic masses.
- Conditions
- Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic Cancer
- Trial name
- CONTACT (NCT01563133)
- Testing
- EUS-FNA, nCLE
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Mauna Kea Technologies
Breast Cancer
Real-Time Near-infrared (NIR) Mapping of Sentinel Lymph Nodes in Breast Cancer
The objective of this Phase II study is to assess the diagnostic accuracy of sentinel lymph node (SLN) identification in patients with breast cancer using near-infrared (NIR) fluorescence optical imaging.
- Trial name
- NCT01468649
- Testing
- NIR Imaging with FLARE and Mini-FLARE Imaging System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Uterine Cervical Dysplasia
Comparison of Pelvic Lymphadenectomy Versus Isolated Sentinel Lymph Node Biopsy Procedure for Early Stages of Cervical Cancers : a Multicenter Study With Evaluation of Medico-economic Impacts
Patients with early cervical cancer are usually treated with radical hysterectomy + pelvic lymph-node dissection. The study randomizes patients in 2 arms.
- Trial name
- SENTICOL2 (NCT01639820)
- Testing
- identification of sentinel nodes + full pelvic lymph-node dissection, only identification of sentinel nodes (without pelvic lymph-node dissection)
- Where
- France
- Volunteers
- 267 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
Precision Medicine in Action: Phase II Trial of Response Adaptive Ablative Pre-operative SPBI (RAPS) and Non-operative Sentinel Lymph Node Biopsy in Patients With Early-stage ER+ Breast Cancer: RAPS Trial
1. Efficacy of PULSAR preoperative radiation 2. Evaluate potential of microbubble CEUS as an alternative to operative SLNBx 3. Evaluate potential of OA to evaluate treatment response of pre-operative radiation on the tumor
- Trial name
- NCT06444269
- Testing
- Radiomics on MRI, microbubble CEUS Contrast Enhanced Ultrasound (CEUS)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer
Adjuvant AI Combined With Zoladex
The present study is a randomized open-label -phase III study that aims to compare the efficacy of Zoladex® combined with Aromidex® for 3-2 years after SERMs (tamoxifen and Fareston®) as an adjuvant therapy for 2-3 years with the…
- Trial name
- NCT01352091
- Testing
- Zoladex+AI, TAM
- Where
- China
- Volunteers
- 670 people
- Sponsor
- Fudan University
Lung Cancer
Comparison of 22-gauge and 19-gauge Aspiration Needle During EBUS-TBNA
Investigators intend to compare the 19-gauge needle and the 22-gauge-needle during EBUS-TBNA concerning the diagnostic yield, the quality and quantity of each biopsy needle without raising the rate of complications.
- Trial name
- NCT02813603
- Testing
- EBUS
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Essen
Colorectal Neoplasms Malignant, Lymph Node Excision
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%.
- Conditions
- Colorectal Neoplasms Malignant, Lymph Node Excision, Chemoradiotherapy
- Trial name
- NCT05129774
- Testing
- Radical surgery with PALND, Radical surgery without PALND
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Breast Cancer, Breast-conserving Surgery
Hemopatch Versus Axillary Drainage After Axillary Lymphadenectomy
Aspirative drainage continues to be the "gold standard" for the management of this post-surgical complication, even though it can lead to complications such as obstruction of the drainage, peritubal leakage of the seroma, etc.
- Conditions
- Breast Cancer, Breast-conserving Surgery, Axillary Lymph Node Dissection
- Trial name
- REDHEMOPACH (NCT04487561)
- Testing
- hemopatch, Aspirative drainage
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Edema Due to Obstruction of Lymph Vessels or Excision of Lymph Nodes
Complete Decongestive Therapy Versus Compression Bandaging in Advanced Secondary Lymphedema
The purpose of this study is to: Find out the efficacy of using complete decongestive physiotherapy on limb volume in advanced secondary upper and lower extremity lymphedema patients.
- Trial name
- NCT04749342
- Testing
- Physiotherapy Treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed Mohamed Abdelrauf
Breast Cancer
OPTimizing Irradiation Through Molecular Assessment of Lymph Node (OPTIMAL)
The main purpose of this study is to show the non-inferiority of the incidental irradiation, as compared to intentional irradiation of the axillary nodes, in terms of 5-years disease-free survival (DFS) of early stage breast…
- Trial name
- OPTIMAL (NCT02335957)
- Testing
- Irradiation
- Where
- 50 sites in Italy, Portugal and 1 more
- Volunteers
- 489 people
- Sponsor
- Grupo de Investigación Clínica en Oncología Radioterapia
HIV/AIDS
Reducing HIV Persistence in Lymph Nodes by Interleukin-15 (IL-15) Receptor Super-agonist (N-803) in Acute HIV Infection
Reducing HIV persistence in lymph nodes by Interleukin-15 (IL-15) Receptor super-agonist (N-803) in Individuals with Acute HIV Infection
- Trial name
- NCT04505501
- Testing
- N-803
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Thai Red Cross AIDS Research Centre
Artificial Intelligence, Endobronchial Ultrasound
AI-EBUS-Elastography for LN Staging
Before any treatment decisions are made for patients with lung cancer, it is crucial to determine whether the cancer has spread to the lymph nodes in the chest.
- Conditions
- Artificial Intelligence, Endobronchial Ultrasound, Elastography, NSCLC
- Trial name
- AI-EBUS-E (NCT04816981)
- Testing
- EBUS-Elastography
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Endometrial Neoplasms, Endometrial Cancer Stage I
Comparison of Two-Position and Four-Position Cervical Injection Techniques for Sentinel Lymph Node Mapping in Endometrial Cancer Using Methylene Blue
This clinical trial evaluates lymph node mapping in newly diagnosed endometrial cancer patients undergoing surgery. The standard technique uses a 2-point methylene blue cervical injection.
- Conditions
- Endometrial Neoplasms, Endometrial Cancer Stage I, Sentinel Lymph Node, Metastasis
- Trial name
- NCT07040657
- Testing
- Sentinel Lymph Node Detection/Cervical Methylene Blue Injection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dokuz Eylul University
Prostate Cancer
Evaluation of the SENSEI® Laparoscopic Tethered Gamma Probe for 99mTc-nanocolloid Sentinel Lymph Node Biopsy in Prostate Cancer
This study is a prospective, open label, single-arm study to examine the performance and safety of the SENSEI® laparoscopic tethered gamma probe in patients undergoing 99mTc-nanocolloid SLNB for prostate cancer (PCa) during RP…
- Trial name
- LPM-012 (NCT04632251)
- Testing
- SENSEI®
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 56 people
- Sponsor
- Lightpoint Medical Limited
FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma
Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study
This study evaluates whether isolated tumor cells in the first lymph nodes near the tumor can tell researchers something important about the future of patients with a certain type of endometrial (uterine) cancer.
- Conditions
- FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma, Stage IA1 Endometrial Cancer FIGO 2023, Stage IA2 Endometrial Cancer FIGO 2023
- Trial name
- NCT06689956
- Testing
- Non-Interventional Study
- Where
- 20 sites in United States, Austria and 8 more
- Volunteers
- 212 people
- Sponsor
- Mayo Clinic
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